Neural control of animal vocalization
- ultrasonic vocalization
- vocal communication
- vocal expression of emotionality
Neural control of locomotor activity
- mechanisms of movement initiation
- patterns of locomotor activity
The general objective of my research is to study neural mechanisms of
behaviour. I am particularly interested in the neural control of vocalization
and locomotion as two major components of overt behaviour. The main questions
raised are what brain structures are involved in initiation and regulation
of these behavioural patterns and what pathways and neurotransmitters
are involved in conveying information and in achieving the integration
of behavioural output. The research plans represent a multidisciplinary
approach ranging from cellular mechanisms and the anatomical organization
of neural brain circuits, to integrative aspects of the neural regulation
of vertebrate behaviour. The ongoing research projects involve behavioural
tests, bioacoustic analyses, measurements of locomotor activity, neuropharmacological,
neurophysiological and histological techniques, and electrophysiological
and histochemical methods.
Brudzynski SM. Pharmacology of Ultrasonic Vocalizations in adult Rats: Significance, Call Classification and Neural Substrate. Curr Neuropharmacol, 2015 (Feb), 13:180-192.
Brudzynski SM. The ascending mesolimbic cholinergic system - a specific division of the
reticular activating system involved in the initiation of negative emotional states. J Mol Neurosci, 2014 (Jul), 53(3):436-445.
Brudzynski SM. Ethotransmission: Communication of emotional states through
ultrasonic vocalization in rats. Curr Opin Neurobiol 2013 (Jun), 23(3):310-317
Brudzynski SM, Komadoski M, St. Pierre J. (2012). Quinpirole-induced 50 kHz ultrasonic vocalization in the rat: Role of D2 and D3 dopamine receptors. Behavioural Brain Research, 226: 511-518.
Brudzynski SM, Iku A, Harness (nee Savoy) A. (2011). Activity of cholinergic neurons in the laterodorsal tegmental nucleus during emission of 22 kHz vocalization in rats. Behavioural Brain Research, 225: 276-283.
Brudzynski, S.M., Silkstone, M., Komadoski, M., Scullion, S., Duffus, S., Burgdorf, J., Kroes, R.A., Moskal, J.R. and Panksepp, J.(2011). Effects of intraacumbens amphetamine on production of 50 kHz vocalization in three lines of selectively bred Long-Evans rats. Behav Brain Res., 217(1): 32-40.
Brudzynski, S.M. (2009). Communication of adult rats by ultrasonic vocalization: Biological, sociobiological, and neuroscience approaches. ILAR Journal, 50(1): 43-50.
Brudzynski, S.M. (2007). Ultrasonic calls of rats as indicator variables of negative or positive states. Acetylcholine-dopamine interaction and acoustic coding. Behavioral Brain Research, 182(2): 261-273.
Brudzynski, S.M. and Holland, G. (2005). Acoustic characteristics of air puff-induced 22-kHz alarm calls in direct recordings. Neurosci Biobehav Rev, 29: 1169-1180.
Brudzynski, S.M. (2005). Principles of rat communication: Quantitative parameters of ultrasonic calls in rats. Behavior Genetics, 35: 85-92.
Brudzynski, S. M., Pniak, A.(2002). Social contacts
and production of 50-kHz short ultrasonic
calls in adult rats. Journal of Comparative
Psychology, 116: 73-82.
Brudzynski, S.M. (2001). Pharmacological and behavioral
characteristics of 22 kHz alarm calls in
rats. Neurosci Biobehav Rev., 25:
Brudzynski, S.M., Kehoe, P. and Callahan,
M. (1999). Sonographic structure of isolation-induced
ultrasonic calls of rat pups. Developmental
Psychobiology, 34: 195-204.
Brudzynski, S.M. and Barnabi, F. (1996).
Contribution of the ascending cholinergic
pathways in the production of ultrasonic
vocalization in the rat. Behavioural
Brain Research, 80: 145-152.