Brian D. Roy, PhD

Associate Dean, Faculty of Graduate Studies and Postdoctoral Affairs (primary), and Kinesiology

Profile Place Holder

Office: MC D255A
905 688 5550 x3779
broy@brocku.ca

I am interested in the regulation of integrated physiological responses and muscle metabolism during physical activity and dietary manipulations. My current work is focused on the impact of alterations in muscle cell volume on the regulation of muscle metabolism and muscle hypertrophy and atrophy. I am also interested in the effects of dietary supplementation of various compounds, including dairy products, on muscle and bone metabolism in healthy, diseased, and ageing populations. I am also currently investigating dietary interventions for the treatment and reduction in severity of sport induced concusssions.

Research Interests

  • Integrated metabolic responses to exercise and nutrition
  • Protein metabolism
  • Interaction of dietary intake of dairy products and physical activity
  • Dietary interventions for sport induced concussions

Publications

Increases in skeletal muscle ATGL and its inhibitor G0S2 following 8 weeks of endurance training in metabolically different rat skeletal muscles. Turnbull PC, Longo AB, Ramos SV, Roy BD, Ward WE, Peters SJ. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 15;310(2):R125-33. doi: 10.1152/ajpregu.00062.2015. PMID: 265115212.

Characterization of lipolytic inhibitor G(0)/G(1) switch gene-2 protein (G0S2) expression in male Sprague-Dawley rat skeletal muscle compared to relative content of adipose triglyceride lipase (ATGL) and comparitive gene identification-58 (CGI-58). Turnbull PC, Ramos SV, MacPherson RE, Roy BD, Peters SJ. PLoS One. 2015 Mar 26;10(3):e0120136. doi: 10.1371/journal.pone.0120136. eCollection 2015. PMID: 258115903.

A maternal high fat diet has long-lasting effects on skeletal muscle lipid and PLIN protein content in rat offspring at young adulthood. MacPherson RE, Castelli LM, Miotto PM, Frendo-Cumbo S, Milburn A, Roy BD, LeBlanc PJ, Ward WE, Peters SJ. Lipids. 2015 Feb;50(2):205-17. doi: 10.1007/s11745-014-3985-5. Epub 2015 Jan 1. PMID: 255523504.

Elevated concentrations of circulating cytokines and correlations with nerve conduction velocity in human peripheral nerves. Allison DJ, Green LA, Gabriel DA, Roy BD, Inglis JG, Ditor DS. J Neuroimmunol. 2014 Dec 15;277(1-2):134-9. doi: 10.1016/j.jneuroim.2014.09.010. Epub 2014 Sep 19. PMID: 252661425.

A School-Based Type 2 Diabetes Prevention Program for Canadian Elementary Students. Lindsey Cline, James Mandigo, Panagiota Klentrou, Brian Roy. PHEnex J. Vol. 6, No. 3, 2014.

Pyruvate Dehydrogenase Kinase-4 Contributes to the Recirculation of Gluconeogenic Precursors During Post-Exercise Glycogen Recovery. Eric Herbst, Rebecca MacPherson, Paul LeBlanc, Brian Roy, Nam Ho Jeoung, Robert Harris, and Sandra Peters. Am J Physiol Regul Integr Comp Physiol. 2013 Dec 4. [Epub ahead of print]6.

Maternal high fat feeding does not have long-lasting effects on body composition and bone health in female and male rat offspring at young adulthood. Paula Miotto, Laura Castelli, Foyinsola Amoye, Paul LeBlanc, Sandra Peters, Brian Roy, Wendy Ward. Molecules. 2013, 18(12), 15094-15109; doi:10.3390/molecules181215094.7.

Skeletal muscle PLIN3 and PLIN5 are serine phosphorylated at rest and following lipolysis during adrenergic or contractile stimulation Rebecca E. K. MacPherson*, Rene Vandenboom, Brian D. Roy, Sandra J. Peters. Physiol Rep, 1 (4), 2013, e00084.

Extracellular hyper-osmotic stress stimulates glucose uptake in incubated fast twitch rat skeletal muscle. Farlinger, C, Lui, AJ, Harrison, RC, LeBlanc, PJ, Peters, SJ, Roy, BD. Appl Physiol Nutr Metab. 38(6):605-12. doi: 10.1139/apnm-2012-0236, 2013.9.

Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction. Macpherson RE, Ramos S, Vandenboom R, Roy BD, Peters SJ. Am J Physiol Regul Integr Comp Physiol. 2013 Apr 15; 304(8):R644-50. doi: 10.1152/ajpregu.00418.2012. Epub 201310.

Role of pyruvate dehydrogenase kinase 4 in regulating PDH activation during acute muscle contraction. Herbst EA, Dunford EC, Harris RA, Vandenboom R, Leblanc PJ, Roy BD, Jeoung NH, Peters SJ. Appl Physiol Nutr Metab. 2012 Feb;37(1):48-52. doi: 10.1139/h11-136. Epub 2011 Dec 23.11.

Muscle cellular properties in the ice hockey player: a model for investigating overtraining? Green HJ, Batada A, Cole B, Burnett ME, Kollias H, McKay S, Roy B, Schertzer JD, Smith IC, Tupling S. Can J Physiol Pharmacol. 2012 May;90(5):567-78. doi: 10.1139/y2012-017. Epub 2012 Apr 3.12.

Subcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscle. Macpherson RE, Herbst EA, Reynolds EJ, Vandenboom R, Roy BD, Peters SJ. Am J Physiol Regul Integr Comp Physiol. 302(1):R29-36, 2012.

Teaching

  • Human Physiology
  • Sport Nutrition
  • Exercise Physiology