Although essential for terrestrial life, the role and importance of skeletal muscle function is often overlooked. My research interests are the structure-function relationships of skeletal muscle cells and the mechanics of skeletal muscle contraction. I am particularly interested in the mechanism of posttetanic potentiation and how this outcome enhances skeletal muscle performance. This interest includes how the posttranslational modification of the myosin “motor” molecule, by phosphorylation of the regulatory light chain, enhances contractile performance. I am also interested in the origin and implications of skeletal muscle fatigue.
- Ontario College of Kinesiology
- Ontario University Ball Hockey Association
- Ontario Ball Hockey Federation
- Canadian Ball Hockey Association
- Member of Society for Epidemiological Research
- Member of Canadian Society for Epidemiology and Biostatistics
Morris S and Vandenboom R. Effect of Beta-Adrenegrgic Stimulation on Posttetanic Potentiation of Wildtype and sMLCK Devoid Mouse Muscle. Journal of Applied Physiology, Nutrition and Metabolism (Under Review) (2017)
Gittings W, Bunda, J. and Vandenboom R. Myosin Phosphorylation Mediated Potentiation Does Not Alter the Economy of Isovelocity Contractions in Mouse Fast Skeletal Muscle In Vitro. Submitted to Skeletal Muscle (Under Review) (2017).
Smith IC, Vandenboom R and Tupling AR. Contraction-Induced Enhancement of Relaxation During Repeated High Force Contractions. Submitted to the Journal of Experimental Biology (Under Review) (2017).
Mikhaeil JS, Sacco SM, Saint C, Gittings W, Bunda J, Giles CR, Fajardo V, Vandenboom R, Ward WE and LeBlanc PJ. Influence of longitudinal micro-CT radiation on contractility and metabolic activity in mouse skeletal muscle. Submitted to Physiological Reports (Under Review) (2017)
Gittings W, Bunda, JB and Vandenboom R. Shortening Speed Dependent Force Potentiation is Attenuated but not Eliminated in Skeletal Muscles Without Myosin Phosphorylation. Journal of Muscle Research and Cell Motility (In Press) 2017.
Vandenboom R. Force Modulation in Skeletal Muscle by Myosin Phosphorylation. In: Pollack D (Ed) American Physiological Society. Comprehensive Physiology 7:171‐212, 2017.
Bowslaugh JJ, Gittings W and Vandenboom R. Myosin Phosphorylation is Required for Peak Power of Mouse Fast Muscle In Vitro. Pflugers Archive: European Journal of Physiology 468(11): 2007-2016, 2016.
Gittings W, Stull JT and Vandenboom R. Interactions Betweent the The Catch Like Property and Posttetanic Potentiation of Mouse Skeletal Muscle. Muscle and Nerve 54(2): 308-316, 2016.
Gittings W, Aggarwal H, Stull JT and Vandenboom R. The Force Dependence of Isometric and Concentric Potentiation in Mouse Muscles With and Without Myosin Light Chain Kinase. Canadian Journal of Physiology and Pharmacology 93(1):23-32, 2015.
Smith IC, Vandenboom R and Tupling R. Juxtaposition of the Changes in Intracellular Calcium and Force During Staircase Potentiation at 30 and 37oC. Journal of General Physiology 144(6):561-570, 2014.
Vandenboom R, Gittings W, Smith IC, Grange RW and JT Stull. Myosin Phosphorylation and Force Potentiation in Skeletal Muscle: Evidence from Animal Models. Journal of Muscle Research and Cell Motility 34(5-6): 317-332, 2013.
Smith I, Gittings W, Bloemberg D, Huang J, Quadrialtero J, Tupling AR and Vandenboom R. Potentiation in Mouse Lumbrical Muscle Without Myosin Light Chain Phosphorylation: Is Resting Calcium Responsible? Journal of General Physiology 141(3): 297-308, 2013.
MacPherson REK, Ramos S, Vandenboom R, Roy BD andPeters SJ. Skeletal Muscle PLIN Proteins, ATGL and CGI-58, Interactions at Rest and Following Stimulated Contraction. American Journal of Physiology (Regulatory, Integrative and Comparative), 304(8): R644-650, 2013.
Inglis G, Vandenboom R and Gabriel DG. Sex-Based Differences in Muscle Activation at Onset of Maximal Voluntary Contractions of Human Biceps Femoris Muscle. Journal of Clinical Biomechanics, 23: 1289-1294, 2013.
MacPherson REK, Vandenboom R, Roy BD and Peters SJ. Skeletal Muscle PLIN Phosphorylation May Not Be Required For Lipolysis With Either Adrenergic or Contractile Stimulation. Physiological Reports 1(4): e00084, 2013.
Gittings W, Huang J. and Vandenboom, R. Tetanic Force Potention of Mouse Fast Muscle is Shortening Speed Dependent. Journal of Muscle Research and Cell Motility 33(5): 359-368, 2012.
MacPherson REK, Herbst EAF, Reynolds EJ, Vandenboom R, Roy B and Peters SJ. Subcellular Location and Colocalization of Lipid Droplet Proteins, ADRP and OXPAT, in Resting and Stimulated Rat Soleus. American Journal of Physiology (Regulatory, Integrative and Comparative) 302(1): R29-36, 2012.
Herbst EAF, Dunford ECE, Harris RA, Vandenboom R, LeBlanc PJ, Roy BD, Jeoung NH and Peters SJ. Role of Pyruvate Dehydrogenase Kinase 4 in Regulating PDH Activation During Acute Muscle Contraction. Appl Physiol, Nutrition Metablism 37(1): 48-52, 2012.
- Exercise Physiology
- Muscle Physiology
- Exercise Prescription
- Training and Testing