Hongbin (Tony) Yan

Assistant Professor

Department of Chemistry

Nucleic Acids

Carbohydrates

Bioconjugates

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     Publications

        21).Yan, H.; KuoLee, R.; Tram, K.; Qiu, H.; Zhang, J.; Patel, G.B.; Chen, W. Intranasal immunization of mice with bacterial second messenger cdiGMP elicits protective immunity against nasopharyngeal carriage of Streptococcus pneumoniae, submitted.

        20). Tram, K.; Yan, H.; Vassiliev, S.; Bruce, D. H. Jenkins, H. Synthesis and crystal structure of unsubstituted BODIPY, Dyes Pigments, 2009, 82, 392.

        19).  Tram, K.; McIntosh, W.; Yan, H. Synthesis of dipyrrolemethano-C-glycosides, Tetrahedron Lett, 2009, 50, 2278

18) Zhao, Y.; Yan, H. Preparation of mannosylated oligoribonucleotides, Nucleic Acids, Sym. Series, 2008, 52, 89-90.

17)  Millar, S.; Yan, H.; Sanghvi, Y.S.; Pon, R. Some observations on detritylation in solid-phase oligonucleotide synthesis, Nucleic Acids, Sym. Series, 2008, 52, 311-312.

16) Yan, H.; Wang, X.; Kuolee, R.; Chen, W. Synthesis and Immunostimulatory Properties of the Phosphorothioate Analogues of cdiGMP, Bioorg. Med. Chem. Lett., 2008, 18, 5631每5634.

15) Tram, K.; Wang, X.; Yan, H. Facile Synthesis of Oligonucleotide Phosphoroselenoates, Org. Lett., 2007, 9, 5103每5106.

14) Yan, H.; Anguilar, A. L. Synthesis of 3',5'-cyclic diguanylic acid (cdiGMP) and its phosphorothioate analogues, Nucleoside, Nucleotides & Nucleic Acids, 2007, 26, 1-16.

13) Yan, H.; Anguilar, A. L.; Zhao, Y. Preparation of Carbohydrate每Oligonucleotide Conjugates Using the Squarate Spacer, Bioorg. Med. Chem. Lett., 2007, 17, 6535每6538.

12) Yan, H.; Tram, K. Glycotargeting to improve cellular delivery efficiency of nucleic acids, Glycoconjug. J., 2007, 26, 189每204.

11) Yan, H.; Jennings, H. J. Synthesis of mono- and di-sialophospholipids via the H-phosphonate approach, Can. J. Chem., 2006, 84, 540-545.

10) Reese, C. B.; Yan, H. Alternatives to the 4,4'-dimethoxytrityl (DMTr) protecting group, Tetrahedron Lett., 2004, 45, 2567-2570.

9)   Reese, C. B.; Yan, H. Further studies with adenosine 5'-dithiophosphoromorpholidate. A convenient preparation of nucleoside phosphorodithioates by a triester approach, Tetrahedron Lett., 2004, 45, 2653-2656.

8)   Reese, C. B.; Yan, H. An approach to the desulfurization of oligonucleotide phosphorothioates, Tetrahedron Lett., 2003, 44, 2501-2504.

7)   Reese, C. B.; Yan, H. Solution phase synthesis of ISIS 2922 (Vitravene) by the modified H-phosphonate approach. J. Chem. Soc., Perkin. Trans. 1, 2002, 23, 2619-2633.

6)   Reese, C. B.; Yan, H. Xanthen-9-ylidene protecting groups in glycerol chemistry. J. Chem. Soc., Perkin Trans. 1, 2001, 15, 1807-1815.

5)   Reese, C. B.; Yan, H. Reaction between pyrrole and orthoesters: preparation of tri-(pyrrole-2-yl)alkanes. Tetrahedron Lett., 2001, 42, 5545-5547.

4)   Reese, C. B.; Song, Q.; Yan, H. Xanthen-9-ylidene and 2,7-dimethylxanthen-9-ylidene protecting groups. Tetrahedron Lett., 2001, 42, 1789-1791.

3)   Chen, M.; Hu, Y.; Yan, H.; Shen, Y. Synthesis of 1,8-naphthalimide derivatives containing polymerizable groups. Chinese J. Org. Chem., 2001, 21, 294-298.

2)   Chen, M.; Yan, H.; Hu, Y.; Shen, Y. Synthesis and characterization of co-polymeric fluorescent colorants of methyl methacrylate and 1,8-naphthalimide containing polymerizable groups. J. East China Univ. Sci. Tech. (Natural Science), 2001, 2, 195-197.

1)  Yan, H.; Luo, X.; Shen, Y. Polymers for electroluminescence. J. Functional Materials, 1998, 29, 578-582.

 

 
   Conferences

18. Nucleic acids symposium, the 92nd Canadian Chemistry Conference and Exhibition, Hamilton, 2009

17. Carbohydrate symposium, the 92nd Canadian Chemistry Conference and Exhibition, Hamilton (Invited speaker) , 2009

16.  The 11th Annual Chemistry & Biochemistry Graduate Student Conference, Montreal , (Keynote speaker) , 2008

15.  Zhao, Y.; Yan, H. Preparation of glycosylated oligonucleotides, 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Kyoto, 2008.

14.  Millar, S.; Yan, H.; Sanghvi, Y. J.; Pon, R. Rapid detritylation does not affect the quality of oligonucleotides, 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Kyoto, 2008.

13.  Ellens, K.; Gordon, H.L.; Chen, W.; Yan, H. Synthesis and Characterisation of cdiGMP and its Analogue, The 13th Symposium on the Latest Trends in Organic Synthesis, 2008, St. Catharines, Ontario.

12.  Tram, K.; Yan, H. Synthesis of Unsubstituted Boron Dipyrromethene (BODIPY) , The 13th Symposium on the Latest Trends in Organic Synthesis, 2008, St. Catharines , Ontario .

11. Zhao, Y.; Yan, H. Towards the Preparation of Mannosylated Luciferase siRNA, The 13th Symposium on the Latest Trends in Organic Synthesis, 2008, St. Catharines, Ontario.

10. Krzywdzinski, A.; Morgan, J.; Gordon, H. L.; Yan, H. De novo design of acyl-homoserine lactone synthase inhibitors, The 13th Symposium on the Latest Trends in Organic Synthesis, 2008, St. Catharines, Ontario.

9. Yan, H. Some observations in oligoribonucleotide synthesis, Perspectives on Therapeutic Nucleic Acids, Sesimbra , Portugal , June 2008.

8. Yan, H.; Wang, X.; Chen, W. Synthesis of cdiGMP and Its Use as Immunoadjuvant, The 18th annual Quebec Ontario Minisymposium in Synthetic and Bioorganic Chemistry, 2007, Montreal

7. Yan, H.; L鏕ez, A. A. Preparation of carbohydrate-oligonucleotide conjugates, 90th Canadian Society for Chemistry meeting, Winnipeg, 2007

6. Yan, H. Convenient synthesis of cdiGMP, 33rd Symposium on Nucleic Acids Chemistry, Osaka , Japan , November 2006.

5. Yan, H. The Cpep for the protection of hydroxyl functions, 2nd Midwest Carbohydrate Symposium, Detroite, 2006 (Invited speaker)

4. Yan, H.; L鏕ez, A. A; Ali, N. Synthesis of oligonucleotides on soluble polyethylene glycol support, The 17th annual Quebec Ontario Minisymposium in Synthetic and Bioorganic Chemistry, 2006, London, Ontario

3. Yan, H.; Reese, C. B. Preparation of oligoribonucleotides in solution via the modified H-phosphonate approach using Cpep as the 2'-OH protecting group. The 12th Symposium on the Latest Trends in Organic Synthesis, 2006, St. Catharines , Ontario .

2. Yan, H.; Jennings , H. Preparation of GM3 ganglioside-protein conjugates bearing a squarate spacer. The 12th Symposium on the Latest Trends in Organic Synthesis, August 9, 2006, St. Catharines , Ontario .

1. Tram, K.; Yan, H. Cpep in Oligoribunucleotide Synthesis, The 17th annual Quebec Ontario Minisymposium in Synthetic and Bioorganic Chemistry, November 2006, London, Ontario, Canada.

 

Invited talks

8. Wayne State University, April 2009

7. University of Guelph, January 2009

6. Concordia University, November 2008

5. East China University of Science and Technology, Aug 2008

4. Norgen Biotek, July 2007

3. University of Akron, March 2007

2. Chengdu Institute of Biology, Chinese Academy of Science, November 2006

1. Hudlicky group seminar, 2005 and 2008