Razvan Simionescu

NMR Technologist, Chemistry

portrait of Razvan Simionescu

Office: CRN 406, Phone: 905 688 5550 x5681
NMR Lab: CRN 112, Phone: 905 688 5550 x6168
razvan.simionescu@brocku.ca

Publications

  • El-Morched, M.; Barroco, C.; Simionescu, R.; Harroun, T.; Yan, H.* Characterization of simulated cytoplasmic fluids, ChemistrySelect 2024, 9, e202402861.
  • Medet Segizbayev, Anton Dmitrienko, Razvan Simionescu, Melanie Pilkington, Georgii Nikonov, Germanium Analogue of the Parent Phosphine-Borane FLP compound, Them. Asian J 2023
  • Juana Goulart Stollmaier, Jared Thomson, Mary Ann Endoma-Arias, Razvan Simionescu, Alexandra Vernaza,Nakya Mesa-Diaz, Mitchell Smith, Liqin Du, Alexander Kornienko, and Tomas Hudlicky, Conversion of Natural Narciclasine to Its C-1 and C-6 Derivatives and Their Antitumor Activity Evaluation: Some Unusual Chemistry of Narciclasine, June 2022, Molecules

  • Aliona G. Baradzenka, Melanie Pilkington, Anton Dmitrienko, Razvan Simionescu, and Georgii I. Nikonov, Reactivity of a Phosphinoamidinate-Stabilized Disilylene toward H–X Bonds, Aug 2021, Inorg. Chem.

  • Nolan Nardangeli, Nikola Topolovčan, Razvan Simionescu, Tomáš Hudlický, Polarization Effect on Regioselectivity of Pd‐Catalyzed Cyclization of 2‐Alkynylbenzaldehydes, Nov 2019, EurJOC
  • Makarova Maria, Endoma-Arias Marie Ann, Dela Paz Helen, Simionescu Razvan, Hudlicky Tomas, Chemoenzymatic Total Synthesis of ent-Oxycodone: Second-, Third-, and Fourth-Generation Strategies, July 2019, JACS
  • Danielle Williams, Yang Qu, Razvan Simionescu and Vincenzo De Luca, The assembly of (+)‐vincadifformine and (‐)‐tabersonine derived monoterpenoid indole alkaloids in Catharanthus roseus involve separate branch pathways, March 2019, The plant Journal
  • Yang Qu, Michael E. A. M. Easson, Razvan Simionescu, Josef Hajicek, Antje M. K. Thamm, Vonny Salim and Vincenzo De Luca, Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine, PNAS March 6, 2018. 201719979
  • Jun, M.; Joshi, D. J.; Yalagala, R.; Valoon, Razvan Simionescu, J.; Lough, A. J.; Gordon, H. L.; Yan H.* Spectroscopic characterization of cyclic azobenzene analogues and confirmation of the structure of trans-cyclic azobenzene by X-ray crystallography, 2018, 3, 2697.
  • Mukund Ghavre, Jordan Froese, Brennan Murphy, Razvan Simionescu, and Tomas Hudlicky, A Formal Approach to Xylosmin and Flacourtosides E and F: Chemoenzymatic Total Synthesis of the Hydroxylated Cyclohexenone Carboxylic Acid Moiety of Xylosmin, Organic. Letters., 2017
  • Yang, L.; Drew, B.; Yalagala, R.; Chaviwala, R.; Simionescu, R.; Lough, A.;* Yan, H.* Solvent-dependent behaviours of 3-amino-1,6-diethyl-4,4-diphenyl-2,5,7-trimethyl-1,5,7,8-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene, Acta Crystallogr. E. 2017, E73, 378.
  • Yang Qu, Razvan Simonescu, and Vincenzo De Luca, Monoterpene Indole Alkaloids from the Fruit of Tabernaemontana Litoralis and Differential Alkaloid Composition in Various Fruit Components, Journal of Natural Products, 2016
  • Lukas Rycek, John J. Hayward, Marwa Abdel Latif, James Tanko, Razvan Simionescu, and Tomas Hudlicky, Chemoenzymatic total synthesis of hydromorphone by an oxidative dearomatization/intramolecular [4+2] cycloaddition sequence: a 2nd generation approach, J. Org. Chem.,2016
  • Yang Qu, Michael L. A. E. Easson, Jordan Froese, Razvan Simionescu, Tomas Hudlicky, and Vincenzo De Luca, Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast, Biological Sciences – Plant Biology 2015,
  • Nikonov G.I., Vyboishchikov S.F., Shirobokov O.G., Simionescu R., “Serendipitous metal catalyzed H–H/Si–H exchange”, accepted to Eur. J. Inorg. Chem. 2014,
  • Mary Ann A. Endoma-Arias, Jason Reed Hudlicky, Razvan Simionescu, Tomas Hudlicky,”Chemoenzymatic Formal Total Synthesis of ent-Codeine and Other Morphinans via Nitrone Cycloadditions and/or Radical Cyclizations. Comparison of Strategies for Control of C-9/C-14 Stereogenic Centers”, Advanced Sythesis and Catalysis, February 2014
  • Andrey Khalimon, Stanislav K. Ignatov, Andrey I. Okhapkin, Razvan Simionescu, Lyudmila G. Kuzmina, Judith A. K. Howard, Georgii I. Nikonov Unusual “Structure, Fluxionality, and Reaction Mechanism of Carbonyl Hydrosilylation by Silyl Hydride Complex [(ArN=)Mo(H)(SiH2Ph)(PMe3)3]”, Chemistry – A European Journal 2013, 19, 8573-8590 • May 13, 2013
  • David Hurem , Andrey G. Moiseev , Razvan Simionescu , and Travis Dudding, “A Detailed NMR- and DFT-Based Study of the Sakurai–Hosomi–Yamamoto Asymmetric Allylation Reaction”, Journal of Organic Chemistry, J. Org. Chem., 78 (9), pp 4440–4445, April 2013
  • Yang, L.; Li, J.; Simionescu, R.; Yan, H*. Observation of two N2-isobutyrylguanine tautomers by NMR spectroscopy, Magn. Reson. Chem., Vol 51., Issue 1, pages 60-64, Jan. 2013
  • Mark Frampton, Razvan Simionescu, Paul M. Zelisko “Enzyme-mediated Synthesis of Silsesquioxanes”, Silicon 04/2012; 1(1):47-56
  • Khalimon A. Y., Shirobokov O.G., Peterson E., Simionescu R., KuzminaL.G., Howard J.A.K., Nikonov, G. I.”Mechanistic Aspects of Hydrolsilylation Catalyzed by (ArN=)Mo(H)(Cl)(PMe3)3“, Inorg. Chem.2012,51 (7), pp 4300–4313
  • An Unexpected Mechanism of Hydrosilylation by a Silyl Hydride Complex of Molybdenum, Andrey Y. Khalimon, Stanislav K. Ignatov, Razvan Simionescu, Lyudmila G. Kuzmina, Judith A. K. Howard, and Georgii I Nikonov, Inorg. Chem., 2012, 51 (2), pp 754–7562012
  • Catalytic and stoichiometric reactivity of β-silylamido agostic complex of Mo: intermediacy of a silanimine complex and applications to multicomponent coupling, Khalimon, Andrey Y.; Simionescu, Razvan; Nikonov, Georgii I.,Journal of the American Chemical Society, 2011, 133(18), 7033-7053.
  • Some observations relating to the stability of the BODIPY fluorophore under acidic and basic conditions: Lijing Yang, Razvan Simionescu, Alan Lough and Hongbin Yan, Dyes and Pigments, 2011
  • Dauben–Michno oxidative transposition of allylic cyanohydrins — Enantiomeric switch of (–)-carvone to (+)-carvone, Jason R. Hudlicky, Lukas Werner, Vladislav Semak, Razvan Simionescu, and Tomas Hudlicky, Canadian Journal of Chemistry, 2011, 89:535-543, 10.1139/v11-026
  • Oleg G. Shirobokov, Serge I. Gorelsky, Razvan Simionescu, Lyudmila G. Kuzmina and Georgii I. Nikonov; The unexpected mechanism of carbonyl hydrosilylation catalyzed by (Cp)(ArN)Mo(H)(PMe3)  Chem. Commun., 2010, 46, 7831-7833
  • Frampton, MB; Simionescu, R; Dudding, T; Zelisko, PM. The Enzymatic Cleavage of Si-O Bonds: A Kinetics Analysis of the Biocatalyzed Hydrolysis of Phenyltrimethoxysilane. J. Mol. Cat. B: Enzymatic, 2010, 66, 105-112.
  • Design of Thermally Stable Versions of the Burgess Reagent: Stability and Reactivity Study, Thomas A. Metcalf, Razvan Simionescu, and Tomas Hudlicky*, J. Org. Chem. 2010, 75, 3447–3450
  • Mark Frampton, Razvan Simionescu and Paul M. Zelisko, “Enzyme-Mediated Synthesis of Silsesquioxanes”, Silicon 2009 , Volume 1, 47-56.
  • Peterson, E.; Khalimon, A. Y.; Simionescu, R.; Kuzmina, L.G.; Howard, J.A.K.; Nikonov, G. I. “Diversity of catalysis by an imido-hydrido complex of molybdenum. Mechanism of carbonyl hydrosilylation and silane alcoholysis.”, J. Am. Chem. Soc. 2009, 113, 1199-1209.
  • Andrey Y. Khalimon, Razvan Simionescu, Lyudmila G. Kuzmina, Judith A. K. Howard and Georgii I. Nikonov “Agostic NSi-H-Mo Complexes: From Curiosity to Catalysis” – Angew. Chem. Int. Ed. 2008, 47, 7701-7704
  • Stephan Ohnmacht, Ryan West, Razvan Simionescu, Jeffrey Atkinson. “Assignment of the 1H and 13C NMR of Tocotrienols”.  Mag. Res. Chem. 2008 46(3), 287-294.
  • Zelisko, PM; Arnelien, KR; Dudding, T; Simionescu, R; Stanisic, H. Enzyme Mediated Cross-Linking of Silicone Polymers. Polymer Preprints, 2007, 48(2), 984-985.
  • Khalimon A. Y., Lin Z., Simionescu R., Vyboishchikov S. F., Nikonov G. I. “Persistent silylium ions stabilized by polyagostic Si-H-Si interactions”, Angew. Chem. Int. Ed. 2007, 46, 4530-4533.
  • Simionescu R., Poehlman W.F.S., Garland, W.J., Performance Support System for I-125 Monitoring in the McMaster University Nuclear, IEEE Transactions on Nuclear Science, Aug. 2006, Volume: 53, Issue: 4, Part 2, On page(s): 2328- 2334