2005-2006 Undergraduate Calendar

Biochemistry describes the structure, organization and function of living systems in molecular terms. The goals of biochemistry are to identify the chemical components and molecules (such as DNA, RNA and protein) of living cells and to determine the function of each component, how components interact, how they are integrated into biological systems, and how these components affect the overall functions of cells and living systems. The Biochemistry Program is a broadly based program designed to provide the student with a thorough understanding of living systems from a molecular perspective. The program is run jointly by the Departments of Biological Sciences and Chemistry.

The Biochemistry Co-op program combines academic and work terms over a five-year period. Students spend two years in an academic setting studying the fundamentals of Biochemistry prior to their first work placement. Successful completion of courses in the core areas of Biochemistry provides the necessary academic background for the work experience. In addition to the current fees for courses in academic study terms, Biochemistry Co-op students are assessed an administrative fee for each work term (see the Schedule of Fees).

Eligibility to continue in the Biochemistry Co-op program is based on the student's major and non-major averages. A student with a minimum 70 percent major average and a minimum 60 percent non-major average may continue. A student with a major average lower than 70 percent will not be permitted to continue in the Biochemistry Co-op program, but may continue in the non co-op Biochemistry stream. If a student subsequently raises his/her major average to 70 percent, the student may be re-admitted only if approved by the Co-op Admissions Committee. For further information, see the Co-op Programs section of the Calendar, and contact the Departments of Biological Sciences or Chemistry.

The Biochemistry Co-op program designation will be awarded to those students who have honours standing and who have successfully completed a minimum of twelve months of Co-op work experience.

Program Notes

1.	Students preparing for professional studies in health sciences should note that many such programs require completion of a laboratory physics course i.e., one credit from PHYS 1P91, 1P92, 1P93.
2.	CHEM 3P40 is strongly recommended for most projects in CHEM 4F90, 4F91 and should be taken in year 3 by students intending to proceed to a year 4 thesis in CHEM.
3.	CHEM 4P27 is strongly recommended when offered.
4.	In all 20 credit degree programs, at least 12 credits must be numbered 2(alpha)00 or above, six of which must be numbered 2(alpha)90 or above and of these, three must be numbered 3(alpha)90 or above. In all 15 credit degree programs, at least seven credits must be numbered 2(alpha)00 or above, three of which must be numbered 2(alpha)90 or above.

Honours Program

Year 1

	BIOL 1F90
	CHEM 1F92
	MATH 1P01 and 1P02 (recommended) or MATH 1P97 and 1P98
	PHYS 1P21 or 1P91 (recommended; see program note 1)
	one of PHYS 1P22, 1P23, 1P92, 1P93 (recommended)
	one Humanities context credit or one Social Science context credit

Year 2

	BIOL 2F01
	one credit from BIOL 2P92, 2P94, 2P96, 2P98
	CHEM 2P12 or 2P63
	CHEM 2P20, 2P21 and 2P42
	the Humanities context credit or Social Science context credit not taken in year 1

Year 3

	BCHM 3P01 and 3P02
	BIOL 3P50
	BIOL 3P51 or 3P91
	CHEM 2P12 or 2P63 (not taken in year 2)
	CHEM 2P32, 3P20 and 3P21
	one-half CHEM credit numbered 2(alpha)90 to 3(alpha)99 (see program note 2)
	one-half elective credit

Year 4

	BIOL 4F90 and 4F91 or CHEM 4F90 and 4F91
	one BCHM credit numbered 4(alpha)00 - 4(alpha)99
	one CHEM credit numbered 3(alpha)99 or above (see program note 3)
	one elective credit

Biochemistry Co-op (Honours only)

Students admitted to the Co-op program must follow an approved program pattern. The most common pattern is listed below. For other approved patterns, consult the Co-op Office.

Year 1

	BIOL 1F90
	CHEM 1F92
	MATH 1P01 and 1P02 or MATH 1P97 and 1P98
	PHYS 1P21 or 1P91 (recommended; see program note 1)
	one of PHYS 1P22, 1P23, 1P92, 1P93 (recommended)
	one Humanities context credit or Social Science context credit

Year 2

	BIOL 2F01
	one credit from BIOL 2P92, 2P96 and 2P98
	CHEM 2P12, 2P20, 2P21 and 2P63
	SCIE 0N90
	the Humanities context credit or Social Science context credit not taken in year 1

Spring/Summer Sessions:

BCHM 0N01

Year 3

Fall Term

	BCHM 3P01
	BIOL 3P50
	CHEM 2P42 and 3P20
	one-half CHEM credit numbered 2(alpha)90 to 3(alpha)99 (see program note 2)

Winter Term:

BCHM 0N02

Year 4

Fall Term:

BCHM 0N03

Winter Term:

	BIOL 3P51 or 3P91
	BCHM 3P02
	CHEM 2P32 and 3P21
	one-half elective credit

Year 5

	BIOL 4F90 and 4F91 or CHEM 4F90 and 4F91
	one BCHM credit numbered 4(alpha)00 - 4(alpha)99
	one CHEM credit numbered 3(alpha)99 or above (see program note 3)
	one elective credit

Pass Program

Satisfactory completion of the first three years of the Honours program entitles a student to apply for a Pass degree.

Course Descriptions

Note that not all courses are offered in every session. Refer to the applicable term timetable for details.

# Indicates a cross-listed course

* Indicates a primary offering of a cross-listed course

Prerequisites and Restrictions

Students must check to ensure that prerequisites are met. Students may be deregistered, at the request of the instructor, from any course for which prerequisites and/or restrictions have not been met.

BCHM 3P01

Metabolic Biochemistry

Biochemical energetics, kinetic regulation of metabolic pathways. Carbon metabolism of carbohydrates, lipids and proteins; nitrogen metabolism.

Lectures, seminar, 3 hours per week; labs, 3 hours per week for six weeks.

Restriction: students must have a minimum of 8.0 overall credits.

Prerequisites: BIOL 2F01 and CHEM 2P20 or permission of the instructor.

BCHM 3P02

Protein Structure and Function

The relationships between protein structure and function. Topics include enzyme kinetics, protein engineering, genomics, and proteomics.

Lectures, seminar, simulations, 3 hours per week.

Restriction: students must have a minimum of 8.0 overall credits.

Prerequisite: BIOL 2F01.

# BCHM 3P25

Wine Chemistry

(also offered as OEVI 3P25)

Sugars, acids, nitrogenous compounds in grape juice; antimicrobial and antioxidant activity of sulfur dioxide; must adjustments; biochemistry of alcoholic and malo-lactic fermentation; bitartrate and protein stability; fining agents; wine aging and phenolic oxidation. Laboratories include juice/wine chemical analysis, fermentation and stability tests.

Lectures, lab, 6 hours per week.

Restriction: open to BCHM, BIOL (single or combined), BTEC, and OEVI majors and OEVI certificate students or permission of the instructor.

Prerequisites: BIOL 2F01, CHEM 2P20 and 2P42.

Note: materials fee required. Students must be a minimum of 18 years of age. It is strongly recommended that students take BCHM 3P01 prior to or concurrent with OEVI (BCHM) 3P25.

# BCHM 3P95

Techniques in Biochemistry and Molecular Biology

(also offered as BIOL 3P95 and BTEC 3P95)

Theory and practice of basic techniques in nucleic acid and protein manipulations and analysis.

Lab, 6 hours per week.

Restriction: students must have a minimum of 8.0 overall credits.

Prerequisite: BIOL 2F01.

Note: designed for students interested in biochemistry, molecular biology and molecular ecology.

* BCHM 4P03

Current Topics in Photobiology

(also offered as BIOL 4P03)

The interaction of light with biological molecules. Effects of ultraviolet radiation, photosynthesis, vision and photoregulation of genes and proteins.

Lectures, seminar, lab, 3 hours per week.

Restriction: students must have either a minimum of 14.0 overall credits or approval to year 4 (honours).

Prerequisite: one-half BCHM credit numbered 3(alpha)00 to 3(alpha)99 or permission of the instructor.

# BCHM 4P06

Bioinformatics

(also offered as BIOL 4P06 and BTEC 4P06)

Genome sequencing projects, gene discovery and gene expression. DNA/RNA/Protein sequence data, including mutagenic processes, molecular evolution and systematics, codon usage, reconstruction of ancient molecules, and prediction of higher-level molecular structure.

Lectures, seminar, 3 hours per week.

Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours).

Note: BCHM 3P02, BIOL 3P50, 3P80 and MATH 1P98 are recommended.

* BCHM 4P08

Topics in Plant and Microbial Biotechnology

(also offered as BIOL 4P08 and BTEC 4P08)

Characterization of biochemical processes and structures. Genetic modification of such processes and structures through molecular manipulation to meet scientific and/or societal needs. Examples include yeast and microbial enzymes or enzyme systems as well as crop proteins and enzymes.

Lectures, seminar, 3 hours per week.

Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours)

Prerequisite: one of BCHM 3P01, 3P02, BIOL 3P50, CHEM 3P63 or permission of the instructor.

# BCHM 4P09

Topics in Animal and Plant Signal Transduction Pathways

(also offered as BIOL 4P09 and BTEC 4P09)

Perception of stimuli to effects on gene expression, emphasizing the molecular/biochemical tools used to study these pathways.

Lectures, seminar, 3 hours per week.

Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours).

Prerequisite: BCHM 3P01.

# BCHM 4P21

Mutagenesis in Disease and Biotechnology

(also offered as BIOL 4P21 and BTEC 4P21)

Exploration of the various mechanisms of mutagenesis of the genetic material, how they contribute to disease and how they can be adapted to produce new biomolecules.

Lectures, seminar, 3 hours per week.

Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours).

Prerequisite: BCHM 3P02 or BIOL 3P50.

# BCHM 4P67

Biophysical Techniques

(also offered as BTEC 4P67 and CHEM 4P67)

Modern instrumental methods of biotechnology emphasizing under-standing theory development of newer technologies which utilize biological components. Topics include optical, X-ray and NMR techniques, separation techniques, hybridization assays, immunoassays, biosensors and mass spectral techniques; membrane chemistry.

Lectures, seminar, 3 hours per week.

Prerequisites: CHEM 2P21 and 2P63 or permission of the instructor.

CO-OP COURSES

BCHM 0N01

Work Placement 1

First Co-op work placement (4 months) with an approved employer.

Restriction: open to BCHM Co-op students.

BCHM 0N02

Work Placement II

Second Co-op work placement (4 months) with an approved employer.

Restriction: open to BCHM Co-op students.

BCHM 0N03