Publications

Papers in refereed journals

(principal author in boldface) (* denotes publications by invitation)

  1. An Improved first-generation Synthesis of ent-Oxycodone. Endoma-Arias, M. A. A.; Makarova, M.; Dela Paz, H. E.; Hudlicky, T. Chemistry Select 2020, 5, 8241-8245.
  2. “Organic synthesis–Where now?” is thirty years old. A reflection on the current state of affairs. Hudlicky, T. Chem. Int. Ed. 2020, DOI 10.1002@anie.202006717. [Accepted and posted on June 4. Censored and withdrawn on June 6 following protest on Twitter].
  3. Sequential enzymatic and electrochemical functionalization of bromocyclohexadienediols: Application to the synthesis of (-)-conduritol C. Stollmaier, J. G.; Hudlický, T. Tetrahedron, 2020, 76, Article 130924 (7 pages).
  4. Polarization effect on regioselectivity of Pd-catalyzed cyclization of 2-alkynylbenzaldehydes. Nardangeli, N.; Topolovčan, N.; Simionescu, R.; Hudlický, T. J. Org. Chem. 2020, 227-233.
2020s
  1. Tetrodotoxin: History, Biology, and Synthesis. Makarova, M.; Rycek, L.; Hajicek, J.; Baidilov, D.; Hudlicky, T. Angew. Chem. Int. Ed. 2019, 58, 18338-18387.
  2. Chemoenzymatic Total Synthesis of ent-Oxycodone: Second-, Third-, and Fourth-Generation Strategies. Makarova, M.; Endoma-Arias, M.; Dela Paz, H. E.; Simionescu, R.; Hudlicky, T. J. Am. Chem. Soc. 2019, 141, 10883–10904
  3. Rapid Access to the Tricyclic Core of Calyciphylline A-Type Alkaloids via Allyl Cyanate-to-Isocyanate Rearrangement. Baidilov, D.; Miskey, S.; Hudlicky, T. J. Org. Chem. 2019, 7590-7595.
  4. Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate. Endoma-Arias, M.; Dela Paz, H. E.; Hudlicky, T. Molecules 2019, 24, 3477
  5. *Chemoenzymatic total synthesis of (+)-oxycodone from phenethyl acetate. Endoma-Arias, M. A. A.; Makarova, M.; Dela Paz, H. E.; Hudlicky, T. Synthesis 2019, 51, 225-232 [special anniversary issue]
  6. Chemoenzymatic synthesis of the Antifungal Compound (-)-Pestynol via a Convergent, Sonogashira Construction of the Central Yne-diene. Borra, S.; Kumar, M.; McNulty, J.; Baidilov, D.; Hudlicky, T. Eur. J. Org. Chem. 2019, 1, 77-79.
  7. Benefits of Unconventional Methods in the Total Synthesis of Natural products. Hudlicky, T., ACS Omega 2018, 3, 17326-17340.
  8. Preparation of rearranged allylic isocyanates from the reaction of allylic alcohols with 1-cyano-4-dimethylaminopyridinium bromide. Baidilov, D.; Makarova, M.; Rycek, L.; Hudlicky, T. Synthesis 2018, 50, 4606-4610.
  9. Chemoenzymatic Synthesis of Advanced Intermediates for Formal Total Syntheses of Tetrodotoxin. Baidilov, D.; Rycek, L.; Trant, J. F.; Froese, J.; Murphy, B.; Hudlicky, T. Angew. Chem. Int. Ed. 2018,  57, 10994-10998.
  10. Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2-epi-Narciclasine. Borra, S.; Lapinskaite, R.; Kempthorne, C.; Liscombe, D.; McNulty, J.; Hudlicky, T. J. Nat. Prod. 2018, 81, 1451-1459.
  11. Repetition of chemistry from a recently retracted paper. A cautionary note. Ryan, W.; Bedard, K.:, Baidilov, D.; Tius. M.; Hudlicky, T. Tetrahedron Lett. 2018, 59, 2467-2469.
  12. Exploiting mitochondrial and oxidative vulnerabilities with a synthetic analog of pancratistatin in combination with piperlongumine for cancer therapy Ma, D.; Gilbert, T.; Pignanelli, C.: Tarade, D.; Noel, M.; Mansour, F.; Gupta, M.; Ma, S.; Ropat, J.; Curran, C.; Vshyvenko, S.; Hudlicky, T.; Pandey, S. The FASEB Journal 2018, 32, 417-430.
  13. *Chemoenzymatic formal total synthesis of pancratistatin from narciclasine type compounds via Myers transposition: Model study for a short conversion of narciclasine to pancratistatin. Lapinskaite, R.; Ghavre, M.; Rintelmann, C.L.; Bedard, K.; Dela Paz, H. E.; Hudlicky, T. Synlett 2017, 28, 2896-2900. [Invited, Special Issue for Vic Snieckus]
  14. Rosmarinic Acid, a Rosemary Extract Polyphenol, Increases Skeletal Muscle Cell Glucose Uptake and Activates. AMPK. Vlavcheski, F.; Naimi, M.; Murphy, B.; Hudlicky, T.; Tsiani, E. Molecules 2017, 22, 1669 (15 pages).
  15. Model studies toward the total synthesis of thebaine by an intramolecular cycloaddition strategy. Koukal, P.; Hajicek, J.; Gupta, S.; Hudlicky, T. Chemistry Select 2017, 2, 7783-7786.
  16. A formal approach to xylosmin and flacourtosides E and F: Chemoenzymatic total synthesis of the hydroxylated cyclohexenone carboxylic acid moiety of xylosmin. Ghavre, M.; Froese, J.; Murphy, B. Simionescu, R.; Hudlicky, T. Org. Lett. 2017, 19, 1156-1159.
  17. Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III. Ma, D.: Pignanelli, C.; Tarade, D.; Gilbert, T.; Noel, M.; Mansour, F.; Adams, S.; Dowhayko, A.; Stokes, K.; Vshyvenko, S.; Hudlicky, T.; McNulty, J.; Pandey, S. Scientific Reports, 2017, 7:42957.
  18. Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation. Naimi, M.; Vlavcheski, F.; Murphy, B.; Hudlicky, T.; Tsiani, E. Clinical and Experimental Pharmacology 2017, 44, 94-102.
  19. *Synthesis of noroxymorphone by N-demethylation/intramolecular acylation of oxymorphone catalyzed by iron(II) chloride. Endoma-Arias, M. A. A.; Machara, A.; Cox, D. P.; Hudlicky, T. Heterocycles 2016, 93, 824-832.[Delayed publication-published in March 2017]
  20. Chemoenzymatic total synthesis of hydromorphone by an oxidative dearomatization/ intramolecular [4+2] cycloaddition sequence: a 2nd generation approach. Rycek, L; Hayward, J. J.; Latif, M. A.; Tanko, J.; Hudlicky, T. J. Org. Chem. 2016, 81, 10930-10941.
  21. Investigation of a new chiral auxiliary derived chemoenzymatically from toluene: Experimental and computational study. Šnajdr, I.; Froese, J.; Dudding, T.; Horáková, P.; Hudlický, T. Can. J. Chem. 2016, 94, 848-856.
  22. Chemoenzymatic total total synthesis of (+)-galanthamine and (+)-narwedine from phenethyl acetate. Endoma-Arias, M. A. A.; Hudlicky, T. Chem.-Eur. J. 2016, 22, 14540-14543.
  23. A chemoenzymatic route to chiral siloxanes: a step toward the enzymatic synthesis of functionalized chiral silicone polymers. Naoum, R.; Séguin, J. P.; Trant, J. F.; Frampton, M. B; Hudlicky, T.; Zelisko, P. M. Tetrahedron. 2016, 72, 4027-4031.
  24. *Synthesis of nororipavine via N- and O-demethylation of iron tricarbonyl complex of thebaine. Machara, A.; Endoma-Arias, M. A. A.; Cisarova, I.; Cox, D. P.; Hudlicky, T. Synthesis 2016, 48, 1803-1813. [feature article, invited]
  25. Chemoenzymatic synthesis of pleiogenone A, an antiproliferative trihydroxyalkylcyclohexenone isolated from Pleiogynium timorense. Froese, J.; Overbeeke, C.; Hudlicky, T.  Chem.-Eur. J. 2016, 22, 6180-6184.
  26. Direct synthesis of noroxymorphone from thebaine; unusual Ce(IV) oxidation of a methoxydiene-iron complex to an enone-g-nitrate. Machara, A.; Endoma-Arias, M. A. A.; Císařová, I.; Cox, D. P.; Hudlicky, T. Eur. J. Org. Chem. 2016, 1500-1503.
  27. Reinvestigation of acetylation of 3,4-dihydroxybenzldehyde and reconciliation of previously reported analytical data. Albinana, C. B.; Hayward, J. J.; Hudlicky, T.; Machara, A. Tetrahedron Lett. 2016, 57, 1019-1021.
  28. Synthesis and olfactory properties of 2-substituted and 2,3-annulated 1,4-dioxepan-6-ones. Plummer, C. M.; Kraft, P.; Froese, J.; Hudlicky, T.; Rook, T. J.; Jones, O. A. H.; Hugel, H. M. Asian J. Org. Chem. 2015, 4, 1075-1084.
  29. *Synthesis of naltrexone and (R)-methylnaltrexone from oripavine via direct oxidation of its quaternary salts. Machara, A.; Werner, L.; Leisch, H.; Carroll, R. J.; Adams, D. R.; Haque, M.; Cox, D. P.; Hudlicky, T. Synlett, 2015, 26, 2101-2108. [Invited manuscript]
  30. Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast. Qu, Y.; Easson, M. L. A. E.; Froese, J.; Simionescu, R.; Hudlicky, T.; De Luca, V. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 6224-6229.
  31. Synthesis of saturated benzodioxepinone analogues: insight into the importance of the aromatic ring-binding motif for marine odorants. Plummer, C. M.; Gericke, R.; Kraft, P.; Raynor, A.; Froese, J.; Hudlicky, T.; J. Rook, T. J.; Jones, O. A. H.; Hugel, H. M. Eur. J. Org. Chem. 2015, 486-495.
  32. Synthesis and biological activity of 10-aza-narciclasine. Vshyvenko, S.; W’Giorgis, Z.; Weber, A.; Neverova, N.; Hedberg, B.; Hudlicky, T. Adv. Synth. Catal. 2015, 357, 83-87.
  33. The chiro-inositols and related cyclitols as chiral monomers for polymerization: expansion of a family of chiral polymers. Trant, J. F.; Ho, H.; Hudlicky, T. Synlett, 2014, 25, 2360-2364.
  34. *Palladium-catalyzed carbonylation of halo arene-cis-dihydrodiols to the corresponding carboxylates. Access to compounds unavailable by toluene dioxygenase-mediated dihydroxylation of the corresponding benzoate esters. Froese, J.; Hudlicky, J. R.; Hudlicky, T. Org. Biomol. Chem. 2014, 12, 7810-7819.
  35. Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-narciclasine and its N-oxide. Vshyvenko, S.; Reisenauer, M. R.; Rogelj, S.; Hudlicky, T. Bioorg. Med. Chem. Lett. 2014, 24, 4236-4238.
  36. Conversion of thebaine to oripavine and other useful intermediates for the semi-synthesis of opiate-derived agents. Synthesis of hydromorphone. Murphy, B.; Šnajdr, I.; Machara, A.; Endoma-Arias, M. A. A.; Stamatatos, T. C.; Cox, D. P.; Hudlicky, T. Adv. Synth. Catal. 2014, 356, 2679-2687.
  37. Processing of o-halobenzoates by toluene dioxygenase. The role of the alkoxy functionality in the regioselectivity of the enzymatic oxidation. Froese, J.; Endoma-Arias, M. A. A.; Hudlicky, T. Org. Process Res. Dev. 2014, 18, 801-809.
  38. Short chemonzymatic total synthesis of ent-hydromorphone by an oxidative dearomatization/intramolecular [4+2] cycloaddition sequence. Varghese, V.; Hudlicky, T. Angew. Chem. Int. Ed. 2014, 53, 4355-4358.
  39. Chemoenzymatic formal total synthesis of ent-codeine and other morphinans via nitrone cycloaddition and/or radical cyclizations. Comparison of strategies for control of C-9/C-14 stereogenic centers. Endoma-Arias, M. A. A.; Hudlicky, J. R.; Simionescu, R.; Hudlicky, T. Adv. Synth. Catal. 2014, 356, 333-339.
  40. *Chemoenzymatic approach to synthesis of hydroxylated pyrrolizidines from benzoic acid. Adams, D. R.; van Kempen, J.; Hudlicky, J. R.; Hudlicky, T. Heterocycles 2014, 88, 1255-1274.
  41. Time-pulsed vacuum and time-pulsed alternating pressure chromatography. Endoma-Arias, M. A. A.; Brindle, I. D.; Hudlicky. T. Synlett, 2014, 25, 58-63.
  42. Ring-opening of hindered cyclic epoxides with potassium carboxylates in the presence of conjugate acids. Trant, J.; Hudlicky, T. Can. J. Chem. 2013, 91, 1179-1185.
  43. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue. Winter, D. K.; Endoma-Arias, M. A.; Hudlicky, T.; Beutler, J. A.; Porco, J. A. J. Org. Chem. 2013, 78, 7617-7626.
  44. General method of synthesis for naloxone, naltrexone, nalbuphone, and nalbuphine by the reaction of Grignard reagents with an oxazolidine derived from oxymorphone. Endoma-Arias , M. A. A.; Cox, D. P.; Hudlicky, T. Adv. Synth. Catal. 2013, 355, 1869-1873.
  45. Heteroatom analogues of hydrocodone: synthesis and biological activity. Giacometti, R. D.; Duchek, J.; Werner, L.; Husni, A. S.; McCurdy, C. R.; Cutler. S. J.; Cox, D. P.; Hudlicky, T. J. Org. Chem. 2013, 78, 2914-2925.
  46. Enzymatic oxidation of para-substituted arenes: access to new non-racemic chiral metabolites for synthesis. Trant, J. F.; Froese, J.; Hudlicky, T. Tetrahedron: Asymmetry 2013, 24, 184-190.
  47. Total synthesis of dihydrocodeine and hydrocodone via a double Claisen rearrangement and C-10/C-11 closure strategy. Varghese, V.; Hudlicky, T. Synlett 2013, 24, 369-374.
  48. Enhancement of apoptotic and autophagic induction by a novel synthetic C-1 analogue of 7-deoxypancratistatin in human breast adenocarcinoma and neuroblastoma cells with tamoxifen. Ma, D.; Collins, J.; Hudlicky, T.; Pandey, S. J. Visualized Experiments 2012, 63, E3586/1-E3586/11.
  49. Unnatural C-1 homologues of pancratistatin: synthesis and promising biological activities. Vshyvenko, S.; Scattolon, J.; Hudlicky, T.; Romero, A. E.; Kornienko, A.; Ma, D.; Tuffley, I.; Pandey, S. Can. J. Chem. 2012, 90, 932-943.
  50. *On hype, malpractice, and scientific misconduct in organic synthesis. Carlson, R.; Hudlicky, T. Helv. Chim. Acta 2012, 95, 2052-2062. [Special issue in honor of Dieter Seebach].
  51. *Application of D-chiro-inositol as a chiral template for the Diels–Alder reaction. Trant, J. F.; Belding, L.; Dudding, T.; Hudlicky, T. Helv. Chim. Acta 2012, 95, 2026-2035. [Special issue in honor of Dieter Seebach].
  52. Direct synthesis of naltrexone by palladium-catalyzed N-demethylation/acylation of oxymorphone. The benefit of C-H activation and the intramolecular acyl transfer from C-14 hydroxy. Machara, A.; Cox, D. P.; Hudlicky, T. Adv. Syn. Catal. 2012, 354, 2713-2718.
  53. Unexpected N-demethylation of oxymorphone and oxycodone N-oxides mediated by the Burgess reagent. Direct synthesis of naltrexone, naloxone, and other antagonists from oxymorphone. Werner, L.; Wernerova, M.; Machara, A.; Endoma-Arias, M. A.; Duchek, J.; Adams, D. R.; Cox, D. P.; Hudlicky, T. Adv. Syn. Catal. 2012, 354, 2706-2712.
  54. A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen. Ma, D.; Tremblay, P.; Mahngar, K.; Akbari-Asl, P.; Collins, J.; Hudlicky, T.; McNulty, J.; Pandey, S. Invest. New Drugs 2012, 30, 1012-1027.
  55. Toluene dioxygenase-mediated oxidation of halogen-substituted benzoate esters. Semak, V.; Metcalf, T. A.; Endoma-Arias, M. A. A.; Mach, P.; Hudlicky, T. Org. Biomol. Chem. 2012, 10, 4407-4416.
  56. Improved synthesis of buprenorphine from thebaine and/or oripavine via palladiium-catalyzed N-demethylation/acylation and/or concomitant O-demethylation. Machara, A.; Werner, L.; Endoma-Arias, M. A.; Cox, D. P.; Hudlicky, T. Adv. Synth. Catal. 2012, 354, 613-626.
  57. *Synthesis of nalbuphine from oripavine via N-demethylation of N-cyclobutylmethyl oripavine. Machara, A.; Cox, D. P.; Hudlicky, T. Heterocycles 2012, 84, 615-623.
  58. Selective cytotoxicity against human osteosarcoma cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin is potentiated by curcumin. Ma, D.; Tremblay, P.; Mahngar, K.; Collins, J.; Hudlicky, T., Pandey, S. PLoS One 2011, 6, e28780.
  59. Several generations of chemoenzymatic synthesis of oseltamivir (Tamiflu): evolution of strategy, quest for a process- quality synthesis, and evaluation of efficiency metrics. Werner, L.; Machara, A.; Sullivan, B.; Carrera, I.; Moser, M.; Adams, D. R.; Hudlicky, T.; Andraos, J. J. Org. Chem. 2011, 76, 10050-10067.
  60. Induction of apoptosis and autophagy in human pancreatic cancer cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin. Ma, D.; Tremblay, P.; Mahngar, K.; Akbari-Asl, P.; Collins, J.; Hudlicky, T.; Pandey, S. Am. J. Biomed. Sci. 2011, 3, 278-291.
  61. Explorations of [4+2] and [5+2] cycloadditions of a dienylcyclopropane derived enzymatically form cyclopropylbenzene. Hudlicky, J. R.; Hopkins-Hill, J.; Hudlicky, T. Synlett 2011, 19, 2891-2895.
  62. A short synthesis of nonracemic iodocyclohexene carboxylate fragment of kibdelone and congeners. Endoma-Arias, M. A. A.; Hudlicky, T. Tetrahedron Lett. 2011, 52, 6632-6634.
  63. Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation. Vshyvenko, S.; Scattolon, J.; Hudlicky, T.; Romero, A. E.; Kornienko, A. Bioorg. Med. Chem. Lett. 2011, 21, 4750-4752.
  64. Chemoenzymatic total synthesis of ent-neopinone and formal total synthesis of ent-codeinone from b-bromoethylbenzene. Duchek, J.; Piercy, T. G.; Gilmet, J.; Hudlicky, T. Can. J. Chem. 2011, 89, 709-728.
  65. Synthesis of buprenorphine via N-demethylation of oripavine quaternary salts. Werner, L.; Machara, A.; Adams, D. R.; Cox, D. P.; Hudlicky, T. J. Org. Chem. 2011, 76, 4628-4634.
  66. Dauben–Michno oxidative transposition of allylic cyanohydrins. Enantiomeric switch of (–)-carvone to (+)-carvone. Hudlicky, J. R.; Werner, L.; Semak, V.; Simionescu, R.; Hudlicky, T. Can. J. Chem. 2011, 89, 535-543.
  67. Chemoenzymatic synthesis of idesolide from benzoic acid. Adams, D. R.; Aichinger, C.; Collins, J.; Rinner, U.; Hudlicky, T. Synlett 2011, 725-729.
  68. On the practical limits of determining isolated product yields and ratios of stereoisomers: reflections, analysis, and redemption. Wernerova, M.; Hudlicky, T. Synlett 2010, 2701-2707.
  69. Recent chemoenzymatic total syntheses of natural and unnatural products: codeine, balanol, pancratistatin, and oseltamivir. Hudlicky, T. Pure Appl. Chem. 2010, 82, 1785-1796.
  70. Design of thermally stable versions of the Burgess reagent: stability and reactivity study. Metcalf, T. A.; Simionescu, R.; Hudlicky, T. J. Org. Chem. 2010, 75, 3447-3450.
  71. Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogs: the next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine. Collins, J.; Rinner, U.; Moser, M.; Hudlicky, T.; Ghiviriga, I.; Romero, A.; Kornienko, A.; Ma, D.; Griffith, C.; Pandey, S. J. Org. Chem. 2010, 75, 3069-3084.
  72. Synthesis of 1,2- and 1,4-amino alcohols from 1,3-dienes via oxazines. Rearrangements of 1,4-amino alcohol derivatives to oxazolines. Werner, L.; Hudlicky, J. R.; Wernerova, M.; Hudlicky, T. Tetrahedron, 2010, 66, 3761-3769.
  73. Short chemoenzymatic azide-free synthesis of oseltamivir (Tamiflu): approaching the potential for process efficiency. Werner, L.; Machara, A.; Hudlicky, T. Adv. Synth. Catal. 2010, 352, 195-200.
2010s
  1. Chemoenzymatic enantiodivergent total syntheses of (+)- and (–)-codeine. Leisch, H.; Omori, A. T.; Finn, K. J.; Gilmet, J.; Bissett, T.; Ilceski, D.; Hudlicky, T. Tetrahedron 2009, 65, 9862-9875.
  2. Biotransfromations of morphine alkaloids by fungi: N-demethylations, oxidations, and reductions. Chaudhary, V; Leisch, H.; Moudra, A.; Allen, B.; De Luca, V.; Cox, D. P.; Hudlicky, T. Collect. Czech. Chem. Commun. 2009, 74, 1179-1193.
  3. Investigation of steric and functionality limits in the enzymatic dihydroxylation of benzoate esters. Versatile intermediates for the synthesis of pseudo-sugars, amino cyclitols, and bicyclic ring systems. Fabris, F.; Collins, J.; Sullivan, B.; Leisch, H.; Hudlicky, T. Org. Biomol. Chem. 2009, 7, 2619-2627.
  4. Symmetry-based design for the chemoenzymatic synthesis of oseltamivir (Tamiflu) from ethyl benzoate. Sullivan, B.; Carrera, I.; Drouin, M.; Hudlicky, T. Angew. Chem. Int. Ed. 2009, 48, 4229-4231.
  5. New options for the reactivity of the Burgess reagent with epoxides in both racemic and chiral auxiliary modes. Structural and mechanistic revisions, computational studies, and application to synthesis. Leisch, H.; Sullivan, B.; Fonovic, B.; Dudding, T.; Hudlicky, T. Eur. J. Org. Chem. 2009, 2806-2819.
  6. One-pot conversion of thebaine to hydrocodone and synthesis of neopinone ketal. Carroll, R. J.; Leisch, H.; Rochon, L.; Hudlicky, T.; Cox, D. P J. Org. Chem. 2009, 74, 747-752.
  7. Formal total synthesis of (–)- and (+)-balanol: two complementary enantiodivergent routes from vinyloxiranes and vinylaziridines. Gilmet, J.; Sullivan, B.; Hudlicky, T. Tetrahedron 2009, 65, 212-220.
  8. Palladium-catalyzed N-demethylation/N-acylation of some morphine and tropane alkaloids. Carroll, R. J.; Leisch, H.; Scocchera, E.; Hudlicky, T.; Cox, D. P. Adv. Synth. Catal. 2008, 350, 2984-2992.
  9. Chemoenzymatic formal synthesis of (–)-balanol. Provision of optical data for an often-reported intermediate. Sullivan, B.; Hudlicky, T. Tetrahedron Lett. 2008, 49, 5211-5213.
  10. Preliminary investigations of the yeast-mediated reduction of b-keto amides derived from cyclic amines as potential resolution methodology. Saxon, R. E.; Leisch, H.; Hudlicky, T. Tetrahedron: Asymmetry 2008, 19, 672-681.
  11. Chiral version of the Burgess reagent and its reactions with oxiranes: application to the formal enantiodivergent synthesis of balanol. Sullivan, B.; Gilmet, J.; Leisch, H.; Hudlicky, T. J. Nat. Prod. 2008, 71, 346-350.
  12. Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy. Collins, J.; Drouin, M.; Sun, X. T.; Rinner, U.; Hudlicky, T. Org. Lett. 2008, 10, 361-364.
  13. Design for morphine alkaloids by intramolecular Heck strategy: chemoenzymatic synthesis of 10-hydroxy-14-epi-dihydrocodeinone via C-D-B ring construction. Zezula, J.; Rice, K. C.; Hudlicky, T. Synlett 2007, 2863-2867.
  14. Chemoenzymatic total synthesis of (+)-codeine by sequential intramolecular Heck cyclizations via C-B-D ring construction. Omori, A. T.; Finn, K. J.; Leisch, H.; Carroll, R. J.; Hudlicky, T. Synlett 2007, 2859-2862.
  15. Synthesis of deuterium-labelled chlorhexidine. Moser, M.; Hudlicky, T.; Sadeghi, S.; Sternin, E. J. Label. Compd. Radiopharm. 2007, 50, 671-674.
  16. Unexpected reactivity of the Burgess reagent with thiols: synthesis of symmetrical disulfides. Banfield, S. C.; Omori, A. T.; Leisch, H.; Hudlicky, T. J. Org. Chem. 2007, 72, 4989-4992.
  17. Studies on regioselective hydrogenation of thebaine and its conversion to hydrocodone. Leisch, H.; Carroll, R. J.; Hudlicky, T.; Cox, D. P. Tetrahedron Lett. 2007, 48, 3979-3981.
  18. Convenient preparation of aryl-substituted nortropanes by Suzuki–Miyaura methodology. Ghosh, S.; Kinney, W. A.; Gauthier, D. A.; Lawson, E. C.; Hudlicky, T.; Maryanoff, B. E. Can. J. Chem. 2006, 84, 555-560.
  19. Cyclotrimerization approach to unnatural structural modifications of pancratistatin and other Amaryllidaceae constituents. Synthesis and biological evaluation. Hudlicky, T.; Moser, M.; Banfield, S. C.; Rinner, U.; Chapuis, J. C.; Pettit, G. R. Can. J. Chem. 2006, 84, 1313- 1337.
  20. Convergent synthesis of 2,3-bisarylpyrazolones through cyclization of bisacylated pyrazolidines and hydrazines. Brugel, T. A.; Hudlicky, T.; Clark, M. P.; Golebiowski, A.; Sabat, M.; Endoma, M. A. A.; Bui, V.; Adams, D.; Laufersweiler, M. J.; Maier, J. A.; Bookland, R. G.; De, B. Tetrahedron Lett. 2006, 47, 3195-3198.
  21. Toluene dioxygenase-mediated oxidation of dibromobenzenes. Absolute stereochemistry of new metabolites and synthesis of (–)-conduritol E. Finn, K. J.; Collins, J.; Hudlicky, T. Tetrahedron 2006, 62, 7471-7476.
  22. Chiral version of the Burgess reagent and its reactions with epoxides. Leisch, H.; Saxon, R.; Sullivan, B.; Hudlicky, T. Synlett 2006, 445-449.
  23. Chemoenzymatic synthesis of complex natural and unnatural products: morphine, pancratistatin, and their analogs. Hudlicky, T. ARKIVOC (Gainesville, FL, U.S.A.) 2006, 276-291. (20th International Congress of Heterocyclic Chemistry, Palermo, Italy, Jul 31-Aug 5, 2005)
  24. Toluene dioxygenase-mediated oxidation of bromo(methylsulfanyl)benzenes. Absolute configuration of metabolites and evaluation of chemo-and regioselectivity trends. Finn, K. J.; Pavlyuk, O.; Hudlicky, T. Coll. Czech. Chem. Commun. 2005, 70, 1709-1726.
  25. Stability relationships in bicyclic ketones. Gordon, H. L.; Freeman, S.; Hudlicky, T. Synlett 2005, 2911-2914.
  26. Processing of cyclopropylarenes by toluene dioxygenase: isolation and absolute configuration of metabolites. Finn, K. J.; Rochon, L.; Hudlicky, T. Tetrahedron: Asymmetry 2005, 16, 3606–3613.
  27. Cyclotrimerization strategy toward analogues of Amaryllidaceae constituents. Synthesis of deoxygenated pancratistatin core. Moser, M.; Sun, X. T.; Hudlicky, T. Org. Lett. 2005, 7, 5669-5672.
  28. Selectivity in the electrochemical deprotection of cinnamyl groups from oxygen and nitrogen functionalities: carbonates versus carbamates. Cankar, P.; Dubas, D.; Banfield, S. C.; Chahma, M.; Hudlicky, T. Tetrahedron Letters 2005, 46, 6851-6854.
  29. Reactions of indole derivatives with oxiranes and aziridines on silica. Synthesis of b-carboline-1-one mimic of pancratistatin. Hudlicky, T.; Rinner, U.; Finn, K. J.; Ghiviriga, I. J. Org. Chem. 2005, 70, 3490-3499.
  30. A b-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: synthesis and biological evaluation. Rinner, U.; Hudlicky, T.; Gordon, H.; Pettit, G.R. Angew. Chem. Int. Ed. 2004, 43, 5342-5346.
  31. Enzymatic oxidation of thioanisoles: isolation and absolute configuration of metabolites. Finn, K. J.; Cankar, P.; Jones, T. R. B.; Hudlicky, T. Tetrahedron: Asymmetry 2004, 15, 2833-2836.
  32. Asymmetric dihydroxylation of cinnamonitrile to trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylonitrile using chlorobenzene dioxygenase in Escherichia coli (pTEZ30). Yildirim, S.; Zezula, J.; Hudlicky, T.; Witholt, B.; Schmid, A. Adv. Synth. Catal. 2004, 346, 933-942.
  33. Synthesis and biological activity of some structural modifications of pancratistatin. Rinner, U.; Hillebrenner, H. L.; Adams, D. R.; Hudlicky, T.; Pettit, G. R. Bioorg. Med. Chem. Lett. 2004, 14, 2911-2915.
  34. New oligomers of conduritol-F and muco-inositol. Synthesis and biological evaluation as glycosidase inhibitors. Freeman, S.; Hudlicky, T. Bioorg. Med. Chem. Lett. 2004, 14, 1209-1212.
  35. Directed evolution of the dioxygenase complex for the synthesis of furanone flavor compounds. Newman, L. M.; Garcia, H.; Hudlicky, T.; Selifonov, S. A. Tetrahedron 2004, 60, 729-724.
  36. Synthesis of chiral ADMET polymers containing repeating D-chiro-inositol units derived from a biocatalytically prepared diene diol. Bui, V. P.; Hudlicky, T. Tetrahedron 2004, 60, 641-646.
  37. New application of Burgess reagent in its reaction with epoxides. Rinner, U.; Adams, D. R.; dos Santos, M. L.; Abboud, K. A.; Hudlicky, T. Synlett 2003, 1247-1252.
  38. Selective electrochemical deprotection of cinnamyl ethers, esters, and carbamates. Hansen, J.; Freeman, S.; Hudlicky, T. Tetrahedron Lett. 2003, 44, 1575-1578.
  39. Synthesis, structure, and biological evaluation of novel N– and O-linked diinositols. Paul, B. J.; Willis, J.; Martinot, T. A.; Ghiviriga, I; Hudlicky, T. J. Am. Chem. Soc. 2002, 124, 10416-10426.
  40. Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives. Hudlicky, T.; Rinner, U.; Gonzalez, D.; Akgun, H.; Schilling, S.; Siengalewicz, P.; Martinot, T. A.; Pettit, G. R. J. Org. Chem. 2002, 67, 8726-8743. [Erratum: J. Org. Chem. 2003, 68, 674]
  41. Enzymatic oxidation of cyclopropylbenzene: structures of new metabolites and possible mechanistic implications. Bui, V. P.; Nguyen, M.; Hansen, J.; Baker, J.; Hudlicky, T. Can. J. Chem. 2002, 80, 708-713.
  42. Medium-scale preparation of useful metabolites of aromatic compounds via whole-cell fermentation with recombinant organisms. Endoma, M. A.; Bui, V. P.; Hansen, J.; Hudlicky, T. Org. Process Res. Dev. 2002, 6, 525–532.
  43. Direct biooxidation of arenes to corresponding catechols with E. coli JM109(pDTG602). Application to synthesis of combretastatins A-1 and A-2. Bui, V. P.; Hudlicky, T.; Hansen, T. V.; Stenstrøm, Y. Tetrahedron Lett. 2002, 43, 2839-2841.
  44. Total synthesis of epi-7-deoxypancratistatin via aza–Payne rearrangement and intramolecular cyclization. Rinner, U.; Siengalewicz, P.; Hudlicky, T. Org. Lett. 2002, 4, 115-117.
  45. Structure assignment of aminoconduritols by 15N NMR correlation spectroscopy; synthesis of a positional isomer of 7-deoxypancratistatin. Schilling, S.; Rinner, U.; Chan, C.; Ghiviriga, I.; Hudlicky, T. Can. J. Chem. 2001, 79, 1659-1667.
  46. The convulsant and anesthetic properties of cis–trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene. Eger, E. I.; Halsey, M. J.; Koblin, D. D.; Laster, M. J.; Ionescu, P.; Königsberger, K.; Fan, R.; Nguyen, B. V.; Hudlicky, T., Anesth. Analg. 2001, 93, 922-927.
  47. Intramolecular Diels–Alder cycloadditions of cis-cyclohexadienediols derived enzymatically from (2-azidoethyl)benzene. Construction of highly functionalized bridged isoquinoline synthons. Zezula, J.; Hudlicky, T.; Ghiviriga I. Coll. Czech. Chem. Commun. 2001, 66, 1269-1286.
  48. Opening of a vinyl aziridine with p-toluenesufonamide under TBAF catalysis: synthesis of 3,4-diamino-3,4-dideoxy-L-chiro-inositol. Paul, B. J.; Hobbs, E.; Buccino, P.; Hudlicky, T. Tetrahedron Lett. 2001, 42, 6433-6435.
  49. The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold. Tullis, J. S.; Laufersweiler, M. J.; VanRens, J. C.; Natchus, M. G.; Bookland, R. G.; Almstead, N. G.; Pikul, S.; De, B.; Hsieh, L. C.; Janusz, M. J.; Branch, T. M.; Peng, S. X.; Jin, Y. Y.; Hudlicky, T.; Oppong, K. Biorg. Med. Chem. Lett., 2001, 11, 1975–1979.
  50. Synthesis of 2′,3′-dideoxy-2′,3′-didehydro nucleosides via a serendipitous route. Guo, Z.; Sanghvi, Y. S.; Brammer, L. E.; Hudlicky, T. Nucleosides, Nucleotides & Nucleic Acids 2001, 20, 1263-1266.
  51. Novel O– and N-linked inositol dimers. A new class of unnatural saccharide mimics. Paul, B. J.; Martinot, T. A.; Willis, J.; Hudlicky, T. Synthesis 2001, 952–956.
  52. Chemoenzymatic synthesis of functionalized cyclohexylglycines and a-methylcyclohexylglycines via Kazmaier–Claisen rearrangement. Hudlicky, T.; Oppong, K.; Duan, C.; Stanton, C.; Laufersweiler, M. J.; Natchus, M. G. Biorg. Med. Chem. Lett., 2001, 11, 627–629.
  53. Selective electrochemical reduction of cinnamyl ethers in the presence of other allylic C–O bonds. Solis–Oba, A.; Hudlicky, T.; Koroniak, L.; Frey, D. Tetrahedron Lett. 2001, 42, 1241-1243.
  54. A study of substrate specificity of toluene dioxygenase in processing aromatic compounds containing benzylic and/or remote chiral centers. Bui, V. P.; Hansen, T. V.; Stenstrøm, Y.; Hudlicky, T.; Ribbons, D. W. New J. Chem., 2001, 25, 116–124.
  55. Direct biocatalytic synthesis of functionalized catechols: a green alternative to traditional methods with high effective mass yield (EMY). Bui, V. P.; Hansen, T. V.; Stenstrøm, Y.; Hudlicky, T. Green Chemistry 2000, 263–265.
  56. Toluene dioxygenase-mediated oxidation of aromatic substrates with remote chiral centers. Bui, V.; Hansen, T. V.; Stenstrom, Y.; Ribbons, D. W.; Hudlicky, T. J. Chem. Soc. Perkin Trans. 1 2000, 1669–1672.
  57. Comparison of approaches to ent-morphine via radical, cationic, and Heck-type cyclizations. Frey, D. A.; Duan, C.; Ghiviriga, I.; Hudlicky, T. Coll. Czech. Chem. Commun. 2000, 65, 561–569.
  58. Practical preparation of potentially anesthetic fluorinated ethyl methyl ethers by means of bromine trifluoride and other methods. Hudlicky, T.; Duan, C.; Reed, J. W.; Yan, F.; Hudlicky, M.; Endoma, M. A.; Eger, E. I. J. Fluorine Chem 2000, 102, 363–367.
  59. A short, stereoselective synthesis of neo-inositol. Hudlicky, T.; Restrepo–Sánchez, N.; Kary, P. D.; Jaramillo–Gómez, L. M. Carbohydr. Res. 2000, 324, 200–203.
2000s
  1. The use of electrochemical methods as an alternative to tin reagents for the reduction of vinyl halides in inositol synthons. Hudlicky, T.; Claeboe, C. D.; Brammer, L. E.; Koroniak, L.; Butora, G.; Ghiviriga, I. J. Org. Chem. 1999, 64, 4909–4913.
  2. Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold. Cheng, M.; De, B.; Almstead, N. G.; Pikul, S.; Dowty, M. E.; Dietsch, C. R.; Dunaway, C. M.; Gu, F.; Hsieh, L. C.; Janusz, M. J.; Taiwo, Y. O.; Natchus, M. G.; Hudlicky, T.; Mandel, M. J. Med. Chem. 1999, 42, 5426–5436.
  3. Model study for a general approach to morphine and noroxymorphone via a rare Heck cyclization. Frey, D. A.; Duan, C.; Hudlicky, T. Org. Lett. 1999, 1, 2085–2087.
  4. Elucidation of the stereochemistry of octahydroisoquinoline derivatives by NMR spectroscopy. Ghiviriga, I.; Bottari, P. Q.; Hudlicky, T. Magn. Reson. Chem. 1999, 37, 653–661.
  5. New arene cis-dihydrodiol metabolites from b-bromostyrenes. Novak, B. H.; Hudlicky, T. Tetrahedron Asymmetry 1999, 10, 2067–2069.
  6. Free radical cyclizations of trienes with tris(trimethylsilyl)silane. Restrepo–Sánchez, N. E.; Gomez, F. J.; Jaramillo–Gomez, L. M.; Hudlicky, T. Synth. Commun. 1999, 29, 2795–2806.
  7. Polyhalogenated methyl ethyl ethers: solubilities and anesthetic properties. Koblin, D. D; Laster, M. J.; Ionescu, P.; Gong, D.; Fang, Z. S.; Eger, E. I.; Halsey, M. J.; Terrell, R. C.; Hudlicky, T. Anesth. Analg. 1999, 88, 1161–1167.
  8. Electron transfer catalyzed [2+2] cycloreversion of benzene dimers. Reddy, G. D.; Wiest, O.; Hudlicky, T.; Schapiro, V.; Gonzalez, D. J. Org. Chem. 1999, 64, 2860–2863.
  9. Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms. Eger, E. I.; Koblin, D. D.; Sonner, J.; Gong, D.; Laster, M. J.; Ionescu, P.; Halsey, M. J.; Hudlicky, T. Anesth. Analg. 1999, 88, 884–892.
  10. Minimum alveolar anesthethic concentration of fluorinated alkanols in rats: relevance to theories of narcosis. Eger, E. I.; Ionescu, P.; Laster, M. J.; Gong, D.; Hudlicky, T.; Kendig, J.; Harris, A.; Trudell, J. R.; Pohorille, A. Anesth. Analg. 1999, 88, 867–876.
  11. Toward a “reagent-free” synthesis: tandem enzymatic and electrochemical methods for increased effective mass yield (EMY). Hudlicky, T.; Frey, D. A.; Koroniak, L.; Claeboe, C. D.; Brammer, L. E. Jr. Green Chem. 1999, 1, 57–59.
  12. Total synthesis of ent-conduramine A and ent-deoxypancratistatin. Akgün, H.; Hudlicky, T. Tetrahedron Lett. 1999, 40, 3081–3084.
  13. A short chemoenzymatic synthesis of (+)-narciclasine. Gonzalez, D.; Martinot, T.; Hudlicky, T. Tetrahedron Lett. 1999, 40, 3077–3080.
  14. Intramolecular N-acyliminium ion–olefin cyclization in the synthesis of optically pure isoquinoline derivatives: control of stereochemistry and application to synthesis of morphine alkaloids. Bottari, P.; Endoma, M. A. A.; Hudlicky, T.; Ghiviriga, I.; Abboud, K. A. Coll. Czech. Chem. Commun 1999, 64, 203–216.
  15. 1-Chloro-(2S,3S)-dihydroxycyclo-hexa-4,6-diene. Hudlicky, T.; Stabile, M. R.; Gibson, D. T.; Whited, G. M. Org. Synth. 1999, 76, 77–85.
  16. Synthesis and biological evaluation of conduritol and conduramine analogs. Desjardins, M.; Lallemand, M. C.; Freeman, S.; Hudlicky, T.; Abboud, K. A. J. Chem. Soc. Perkin Trans. 1. 1999, 621–628.
  17. Chemoenzymatic enantiodivergent synthesis of 1,2-dideoxy-2-amino-1-fluoro-allo-inositol. Oppong, K. A.; Hudlicky, T.; Yan, F.; York, C.; Nguyen, B. V. Tetrahedron, 1999, 55, 2875–2880.
  18. (7R,8S,10bR)-7,8-Dihydroxy-1,5,6,7,8,9,10,10b-octahydro-3H-1,3-oxazolo[4,3-a]isoquinolin-3-one. Abboud, K. A.; Butora, G.; Fearnley, S. P.; Gum, A. G.; Stabile, M. R.; Hudlicky, T. Acta Cryst. 1998, C54, 1162-1164.
  19. Inositol synthesis: concise preparation of L-chiro-inositol and muco-inositol from a common intermediate. Brammer, L. E.; Hudlicky, T. Tetrahedron: Asymmetry 1998, 9, 2011-2014.
  20. Toward a practical synthesis of morphine. The first several generations of a radical cyclization approach. Butora, G.; Hudlicky, T.; Fearnley, S. P.; Stabile, M. R.; Gum, A. G.; Gonzalez, D. Synthesis 1998, 665-681.
  21. Advanced intramolecular Diels–Alder study toward the synthesis of (–)-morphine: structure correction of a previously reported Diels–Alder product. Butora, G.; Gum, A. G.; Hudlicky, T.; Abboud, K. A. Synthesis 1998, 275-278.
  22. New metabolites from the microbial oxidation of fluorinated aromatic compounds. Hudlicky, T.; Gonzalez, D.; Stabile, M.; Endoma, M. A. A.; Deluca, M.; Parker, D.; Gibson, D. T.; Resnick, S. M.; Whited, G. M. J. Fluor. Chem. 1998, 89, 23-30.
  23. Chemosynthetic synthesis of all four stereoisomers of sphingosine from chlorobenzene: glycosphingolipid precursors. Nugent, T. C.; Hudlicky, T. J. Org. Chem. 1998, 63, 510-520
  24. Chemoenzymatic and electrochemical oxidations in the synthesis of octahydroisoquinolines for conversion to morphine. Relative merits of radical vs. acid-catalyzed cyclizations. Endoma, M. A.; Butora, G.; Claeboe, C. D.; Hudlicky, T.; Abboud, K. A. Tetrahedron Lett. 1997, 38, 8833-8836.
  25. A practical multigram-scale synthesis of allo-inositol. Desjardins, M.; Brammer, L. E.; Hudlicky, T. Carbohyd. Res. 1997, 304, 39-42.
  26. Synthesis of conduritol, conduramine, and validoxylamine analogs from tetrahyronaphthalene-cis-diol. Lallemand, M. C.; Desjardins, M.; Freeman, S.; Hudlicky, T. Tetrahedron Lett. 1997, 38, 7693-7396.
  27. Electrochemical versus anionic oxygenation of azathymine derivatives. Butora, G.; Reed, J. W.; Hudlicky, T.; Brammer, L. E., Jr.; Higgs, P. I.; Simmons, D. P.; Heard, N. E. J. Am. Chem. Soc. 1997, 119, 7694-7701.
  28. Chemoenzymatic synthesis of fluorinated carbohydrates: 2-deoxy-2-fluoro-D-glucose and 5-deoxy-5-fluoro-manno-g-lactol. Yan, F.; Nguyen, B. V.; York, C.; Hudlicky, T. Tetrahedron 1997, 53, 11541-11548.
  29. Chemoenzymatic synthesis of deoxyfluoroinositols: 5-deoxy-5-fluoro-myo-inositol and 3-deoxy-3-fluoro-L-chiro-inositol. Nguyen, B. V.; York, C.; Hudlicky, T. Tetrahedron 1997, 53, 8807-8814.
  30. Regio- and stereo-chemical outcomes in the nucleophilic ring cleavage reactions of mono-epoxides derived from cis-1,2-dihydrocatechols. Banwell, M. G.; Haddad, N.; Hudlicky, T.; Nugent, T. C.; Mackay, M. F.; Richards, S. L. J. Chem. Soc. Perkin Trans. 1, 1997, 1779-1791.
  31. Polyhydroxylated tetrahydronaphthalene ethers. Synthesis and molecular properties. Desjardins, M.; Lallemand, M. C.; Hudlicky, T.; Abboud, K. A. Synlett 1997, 728-730.
  32. New metabolites from toluene dioxygenase dihydroxylation of oxygenated biphenyls. Gonzalez, D.; Schapiro, V.; Seoane, G.; Hudlicky, T. Tetrahedron: Asymmetry 1997, 8, 975-977.
  33. Chemoenzymatic synthesis of unnatural amino acids via modified Claisen rearrangement of glycine enolates. Approach to morphine synthesis. Gonzalez, D.; Schapiro, V.; Seoane, G.; Hudlicky, T.; Abboud, K. J. Org. Chem. 1997, 62, 1194-1195.
  34. Chemoenzymatic synthesis of the morphine skeleton via radical cyclization and C10–C11 closure. Butora, G.; Hudlicky, T.; Fearnley, S. P.; Gum, A. G.; Stabile, M. R.; Abboud, K. Tetrahedron Lett. 1996, 37, 8155-8158.
  35. Toluene dioxygenase-mediated cis-dihydroxylation of aromatics in enantioselective synthesis. Asymmetric total syntheses of pancratistatin and 7-deoxypancratistatin, promising anti-tumor agents. Hudlicky, T.; Tian, X.; Königsberger, K.; Maurya, R.; Rouden, J.; Fan, B. J. Am. Chem. Soc. 1996, 118, 10752-10765.
  36. Current status and future perspectives of cyclohexadiene-cis-diols in organic synthesis: versatile intermediates in the concise design of natural products. Hudlicky, T.; Thorpe, A. J. J. Chem. Soc. Chem. Commun. 1996, 1993. [Feature Article]
  37. Nucleophilic substitution of protected b-bromoethyl cyclohexadiene-cis-diol as an alternative to direct microbial oxidation of b-functionalized phenethyl substrates. Hudlicky, T.; Endoma, M. A. A,; Butora, G. J. Chem. Soc. Perkin Trans. 1, 1996, 2187-2192.
  38. Toluene-dioxygenase-mediated cis-dihydroxylation of aromatics in enantioselective synthesis. Iterative glycoconjugate coupling strategy and combinatorial design for the synthesis of oligomers of nor-saccharides, inositols and pseudosugars with interesting molecular properties. Hudlicky, T.; Abboud, K. A.; Entwistle, D. A.; Fan, R.; Maurya, R.; Thorpe, A. J.; Bolonick, J.; Myers, B. Synthesis 1996, 897–911. [Feature Article]
  39. Concise syntheses of 1,2-L-chiro-inositol conjugates and oligomers: a novel class of saccharide mimics with promising molecular properties. Hudlicky, T.; Abboud, K. A.; Bolonick, J.; Maurya, R.; Stanton, M. L.; Thorpe, A. J. J. Chem. Soc. Chem. Commun. 1996, 1717-1718.
  40. Biocatalytic syntheses of protected D-mannose-d5, D-mannose-d7, D-mannitol-2,3,4,5,6-d5, and D-mannitol-1,1,2,3,4,5,6,6-d8. Hudlicky, T.; Pitzer, K. K.; Stabile, M. R.; Thorpe, A. J.; Whited, G. M. J. Org. Chem. 1996, 61, 4151-4153.
  41. New chiral synthons from the microbial oxidation of bromonaphthalenes. Hudlicky, T.; Endoma, M. A. A.; Butora, G. Tetrahedron: Asymmetry, 1996, 7, 61-68.
  42. Asymmetric total synthesis of (+)-7-deoxypancaratistatin. Tian, X.; Maurya, R.; Königsberger, K.; Hudlicky, T. Synlett, 1995, 1125-1126.
  43. Oxidation of 2-(2-bromoethyl)bromobenzene with toluene dioxygenase: isolation and identification of new chiral synthons. Stabile, M. R.; Hudlicky, T.; Meisels, M. L.; Butora, G.; Gum, A. G.; Fearnley, S. P.; Thorpe, A. J.; Ellis, M. R. Chirality 1995, 7, 556-559.
  44. Unusual dehalogenation of a bridgehead halide. Biocatalytic conversion of halocyclohexadiene-cis-diols to the trans-isomers and synthesis of optically pure cyclohexadiene-trans-diols. McKibben, B. P.; Barnosky, G. S.; Hudlicky, T. Synlett, 1995, 806-808.
  45. The synthesis of 4-amino-4-deoxy-D-mannose and glucosamine: a new methodology for the design of homochiral amino sugars from non-carbohydrate precursors. Pitzer, K.; Hudlicky, T. Synlett, 1995, 803-805.
  46. Intramolecular Diels–Alder reactions of the furan diene (IMDAF); rapid construction of highly functionalized isoquinoline skeletons. Hudlicky, T.; Butora, G.; Fearnley, S. P.; Gum, A. G.; Persichini, P. J.; Stabile, M. R.; Merola, J. J. Chem. Soc. Perkin Trans. 1 1995, 2393-2398.
  47. Synthesis of pseudo sugars from microbial metabolites. Entwistle, D. A.; Hudlicky, T. Tetrahedron Lett. 1995, 36, 2591-2594.
  48. First total synthesis of (+)-pancratistatin: an unusual set of problems. Tian, X.; Hudlicky, T.; Königsberger, K. J. Am. Chem. Soc. 1995, 117, 3643-3644.
  49. New chiral synthon from bromoethylbenzene: absolute stereochemistry of a biooxidation metabolite. Stabile, M. R.; Hudlicky, T.; Meisels, M. L. Tetrahedron: Asymmetry 1995, 6, 537-542.
  50. Chemoenzymatic synthesis of D-erythro-C18- and L-threo-C18-sphingosines. Hudlicky, T.; Nugent, T.; Griffith, W. J. Org. Chem. 1994, 59, 7944-7946.
  51. Glycoconjugate coupling strategy: synthesis of a L-chiro-inositol-gala-quercitol conjugate and the synthesis of (+)-proto-quercitol. Hudlicky, T.; Thorpe, A. J. Synlett 1994, 11, 899-901.
  52. Oxidation of 2-methoxynaphthalene by toluene, naphthalene, and biphenyl dioxygenases: structure and absolute stereochemistry of metabolites. Whited, G. M.; Downie, J. C.; Hudlicky, T.; Fearnley, S. P.; Olivo, H. F.; Parker, D.; Dudding, T. J. Bioorg. Med. Chem. 1994, 2, 727–734.
  53. Oxa- and azabicyclo[4.1.0]heptenes as new synthons for C-disaccharide and alkaloid synthesis. Reactivity trends with carbon nucleophiles. Hudlicky, T.; Tian, X.; Königsberger, K.; Rouden, J. J. Org. Chem. 1994, 59, 4037-4039.
  54. Molecular properties of the “ideal” inhaled anesthetic: studies of fluorinated methanes, ethanes, propanes and butanes. Eger, E. I.; Liu, J.; Koblin, D. D.; Laster, M. J.; Taheri, S.; Halsey, M. J.; Ionescu, P.; Chortkoff, B. S.; Hudlicky, T. Anesth. Analg. 1994, 79, 245–251.
  55. Microbial oxidation of aromatics in enantiocontrolled synthesis. Part 3: Design of amino cyclitols (exo-nitrogenous) and total synthesis of (+)-lycoricidine via acylnitrosyl cycloaddition to polarized 1-halo-1,3-cyclohexadienes. Hudlicky, T.; Olivo, H. F.; McKibben, B. J. Am. Chem. Soc. 1994, 116, 5108-5115.
  56. Microbial oxidation of aromatics in enantiocontrolled synthesis. Part 2: Rational design of aza sugars (endo-nitrogenous). Total synthesis of (+)-kifunensine, mannojirimycin and other glycosidase inhibitors. Hudlicky, T.; Rouden, J.; Luna, H.; Allen, S. J. Am. Chem. Soc. 1994, 116, 5099-5107.
  57. Microbial oxidation of aromatics in enantiocontrolled synthesis. Part 1: Expedient and general asymmetric synthesis of inositols and carbohydrates via an unusual oxidation of a polarized diene with potassium permanganate. Hudlicky, T.; Mandel, M.; Rouden, J.; Lee, R. S.; Bachmann, B.; Dudding, T.; Yost, K.; Merola, J. S. J. Chem. Soc. Perkin Trans. 1 1994, 1553-1567.
  58. New cycloaddition chemistry of 1-chloro-5,6-cis-isopropylidenedioxycyclohexa-1,3-diene derived from the oxidation of halogenobenzenes by Pseudomonas putida 39D. Hudlicky, T.; McKibben, B. P. J. Chem. Soc. Perkin Trans. 1 1994, 485-486.
  59. Microbial oxidation of 2-bromostyrene by Psuedomonas putida 39/D. Isolation and identification of metabolites. Königsberger, K.; Hudlicky, T. Tetrahedron: Asymmetry 1993, 4, 2469-2474.
  60. From chlorobenzene to a carbohydrate in two steps. A new chemoenzymatic synthesis of 2,3-O-isopropylidene-D-erythruronolactone. Mandel, M.; Hudlicky, T.; Kwart, L. D.; Whited, G. M. Collect. Czech. Chem. Commun. 1993, 58, 2517-2522.
  61. New diol metabolites derived by biooxidation of chlorostyrenes with Pseudomonas putida: determination of absolute stereochemistry and enantiomeric excess by convergent syntheses. Hudlicky, T.; Boros, E. E.; Boros, C. H. Tetrahedron: Asymmetry 1993, 4, 1365-1386.
  62. Conduritol-halo epoxides: versatile synthons for cyclitol synthesis. Mandel, M.; Hudlicky, T. Synlett 1993, 418-420.
  63. Total synthesis of (+)-kifunensine, a potent glycosidase inhibitor. Rouden, J.; Hudlicky, T. J. Chem. Soc. Perkin 1 1993, 1095-1097.
  64. New Diels–Alder dimers of (1S, 2R)-cis-1,2-isopropylidene-dioxy-3-ethenylcyclohexa-3,5-diene. Hudlicky, T.; Boros, C. H. Tetrahedron Lett. 1993, 34, 2557-2560.
  65. General synthesis of inositols by hydrolysis of conduritol epoxides obtained biocatalytically from halogenobenzenes: (+)-D-chiro-inositol, allo-inositol, muco-inositol, and neo-inositol. Mandel, M.; Hudlicky, T. J. Chem. Soc. Perkin Trans. 1 1993, 741-743. [Erratum: J. Chem. Soc. Perkin Trans. 1 1993, 1537]
  66. Unusual oxidation of 1-halo-1,3-dienes with permanganate. Expedient syntheses of (+)-D-chiro-3-inosose and (+)-D-chiro-inositol from chlorobenzene. Mandel, M.; Hudlicky, T.; Kwart, L. D.; Whited, G. M. J. Org. Chem. 1993, 58, 2331-2333.
  67. Rational design of aza sugars via biocatalysis: mannojirimycin and other glycosidase inhibitors. Hudlicky, T.; Luna, H.; Rouden, J. J. Org. Chem. 1993, 58, 985-987.
  68. A short synthesis of (+)-lycoricidine. Hudlicky, T.; Olivo, H. F. J. Am. Chem. Soc. 1992, 114, 9694-9696.
  69. Practical preparation of some potentially anesthetic fluoroalkanes: regiocontolled introduction of hydrogen atoms. Hudlicky, T.; Fan, R.; Reed, J. W.; Carver, D. R.; Hudlicky, M.; Eger, E. I. J. Fluor. Chem. 1992, 59, 9–14.
  70. Chemoenzymatic enantiocontrolled synthesis of (–)-specionin. Hudlicky, T.; Natchus, M. G. J. Org. Chem. 1992, 57, 4740-4746.
  71. Microbial oxidation of o-chlorostyrene: determination of absolute stereochemistry of the cis-diol metabolite by a convergent synthesis utilizing an intramolecular Diels–Alder reaction. Hudlicky, T.; Boros, E. E.; Boros, C. H. Synlett 1992, 391-393.
  72. Selectivity in [2+3] and [4+3] annulations. Cope rearrangement of (silyloxy)divinylcyclopropane systems leading to functionalized bicyclo[3.2.n]alkenyl derivatives. Hudlicky, T.; Nguyen, P. V. J. Org. Chem. 1992, 57, 1933-1935.
  73. Homochiral amine synthesis by baker’s yeast resolution of a b-keto amide: 1-phenylethylamine. Hudlicky, T.; Gillman, G.; Andersen, C. Tetrahedron: Asymmetry 1992, 3, 281-286.
  74. Palladium-catalyzed coupling of terminal alkynes to the free cis-diol metabolite produced from the oxidation of bromobenzene by Pseudomonas putida: synthesis of new homochiral 3-alkynyl cis-cyclohexa-3,5-diene-1,2-diols. Hudlicky, T.; Boros, E. E. Tetrahedron: Asymmetry 1992, 3, 217-220.
  75. Stereoselective dimerizations of arene-cis-diol acetonides derived from the oxidation of halobenzenes by Pseudomonas putida: absolute configuration of the adducts by x-ray crystallography. Hudlicky, T.; Boros, E. E.; Olivo, H. F.; Merola, J. S. J. Org. Chem. 1992, 57, 1026-1028.
  76. Improved practical synthesis of a prostaglandin and carbocyclic nucleoside synthon. Hudlicky, T.; Natchus, M. G.; Nugent, T. C. Synth. Commun. 1992, 22, 151-157.
  77. A model study directed towards a practical enantioselective total synthesis of (–)-morphine. Hudlicky, T.; Boros, C. H.; Boros, E. E. Synthesis 1992, 174-178.
  78. Biocatalysis as a rational approach to enantiodivergent synthesis of highly oxygenated compounds: (+)- and (–)-pinitol and other cyclitols. Hudlicky, T.; Rulin, F.; Tsunoda, T.; Luna, H.; Andersen, C.; Price, J. D. Isr. J. Chem. 1991, 31, 229-238.
  79. Biocatalysis as a strategy of choice in the exhaustive enantiomerically controlled synthesis of conduritols. Hudlicky, T.; Luna, H.; Olivo, H. F.; Andersen, C.; Nugent, T.; Price, J. D. J. Chem. Soc. Perkin Trans. 1 1991, 2907-2917. [Erratum: J. Chem. Soc. Perkin Trans. 1 1993, 535]
  80. Stereospecific synthesis of aminocyclitols via cycloadditions of unsymmetrical optically pure dienes: conduramine A-1 and dihydroconduramine A-1. Hudlicky, T.; Olivo, H. F. Tetrahedron Lett. 1991, 32, 6077-6080.
  81. Enantiocontrolled total synthesis of conduritols: (+)-conduritol E and (–)-conduritol F. Hudlicky, T.; Price, J. D.; Olivo, H. F. Synlett 1991, 645-646.
  82. A new [2+3] annulation for highly functionalized dihydrofurans via C–C bond formation. Hudlicky, T.; Barbieri, G. J. Org. Chem. 1991, 56, 4598-4600.
  83. Yeast-mediated resolution of b-keto esters of prochiral alcohols. Hudlicky, T.; Tsunoda, T.; Gadamasetti, K. G.; Murry, J. A.; Keck, G. E. J. Org. Chem. 1991, 56, 3619-3623.
  84. Efficient and enantiodivergent synthesis of (+)- and (–)-pinitol. Hudlicky, T.; Price, J. D.; Rulin, F.; Tsunoda, T. J. Am. Chem. Soc. 1990, 112, 9439-9440.
  85. Formal total synthesis of ipomeamarone via the [2+3] dihydrofuran annulation. Hudlicky, T.; Lovelace, T. C. Synth. Commun. 1990, 20, 1721-1732.
  86. An overview of the total synthesis of pyrrolizidine alkaloids via [4+1] azide–diene annulation methodology. Hudlicky, T.; Seoane, G.; Price, J. D.; Gadamasetti, K. G. Synlett 1990, 433-440.
  87. Synthesis of b-methoxy enones via a new two-carbon extension of carboxylic acids. Hudlicky, T.; Olivo, H. F.; Natchus, M. G.; Umpierrez, E. F.; Pandolfi, E.; Volonterio, C. J. Org. Chem. 1990, 55, 4767-4770.
  88. Microbial oxidation of chloroaromatics in the enantiodivergent synthesis of pyrrolizidine alkaloids: trihydroxyheliotridanes. Hudlicky, T.; Luna, H.; Price, J. D.; Rulin, F. J. Org. Chem. 1990, 55, 4683-4687.
  89. Practical synthesis of vinylcyclopropane. Tsunoda, T.; Hudlicky, T. Synlett 1990, 322.
  90. Microbial oxidation of chloroaromatics in the enantiocontrolled synthesis of cyclitols: (–)-dihydroconduritol C. Hudlicky, T.; Price, J. D.; Luna, H.; Andersen, C. M. Synlett 1990, 309-310.
  91. 4-Siloxy-a-bromocrotonate: a new reagent for [2+3] annulation leading to oxygenated cyclopentenes at low temperatures. Hudlicky, T.; Heard, N. E.; Fleming, A. J. Org. Chem. 1990, 55, 2570-2572.
  92. Microbial oxidation of chloroaromatics in enantioselective synthesis of carbohydrates: L-ribonic-g-lactone. Hudlicky, T.; Price, J. D. Synlett 1990, 159-160.
  93. Microbial oxidation of naphthalene derivatives. Absolute configuration of metabolites. Deluca, M. E.; Hudlicky, T. Tetrahedron Lett. 1990, 31, 13-16.
1990s
  1. Tin analogs of the vinylogous Reformatsky reaction. Regio- and stereochemical considerations. Fan, R.; Hudlicky, T. Tetrahedron Lett. 1989, 30, 5533-5536.
  2. A Michael alternative to cyclopentene annulations. Hudlicky, T.; Maxwell, M. H. Synth. Commun. 1989, 19, 1847-1858.
  3. An enantiodivergent approach to D- and L-erythrose via microbial oxidation of chlorobenzene. Hudlicky, T.; Luna, H.; Price, J. D.; Rulin, F. Tetrahedron Lett. 1989, 30, 4053-4054.
  4. Enantioselective synthesis of (–)-zeylena from styrene. Hudlicky, T.; Seoane, G.; Pettus, T. J. Org. Chem. 1989, 54, 4239-4243.
  5. The [2+3] and [3+4] annulation of enones. Enantiocontrolled total synthesis of (–)-retigeranic acid. Hudlicky, T.; Fleming, A.; Radesca, L. J. Am. Chem. Soc. 1989, 111, 6691-6707. [Erratum, J. Am. Chem. Soc. 1989, 111, 9136]
  6. [2+3] Dihydrofuran annulation via vinyloxiranation of carbonyl compounds. Hudlicky, T.; Fleming, A.; Lovelace, T. C. Tetrahedron 1989, 45, 3021-3037.
  7. 3-Hydroxy-1-cyclohexene-1-carboxaldehyde (l-cyclohexene-1-carboxaldehyde, 3-hydroxy-). Rigby, H. L.; Neveu, M.; Pauley, D.; Ranu, B. C.; Hudlicky, T. Org. Synth. 1989, 67, 205-209.
  8. 4,4-Dimethyl-2-cyclopenten-1-one (2-cyclopenten-1-one, 4,4-dimethyl-). Pauley, D.; Anderson, F.; Hudlicky, T. Org. Synth. 1989, 67, 121-124.
  9. Short enantioselective synthesis of (–)-retigeranic acid via [2+3] annulation. Hudlicky, T.; Radesca–Kwart; L.; Li, L.; Bryant, T. Tetrahedron Lett. 1988, 29, 3283-3286.
  10. Enantioselective synthesis through microbial oxidation of arenes. 1. Efficient preparation of terpene and prostanoid synthons. Hudlicky, T.; Luna, H.; Barbieri, G.; Kwart, L. D. J. Am. Chem. Soc. 1988, 110, 4735-4741.
  11. Intramolecular [4+1] pyrroline annulation via azide–diene cycloadditions. 2. Formal stereoselective total synthesis of (±)-platynecine, (±)-hastanecine, (±)-turneforcidine, and (±)-dihydroxyheliotridane. Hudlicky, T.; Seoane, G.; Lovelace, T. C. J. Org. Chem. 1988, 53, 2094-2099.
  12. Synthesis of eburnamonine and dehydroaspidospermidine. Wenkert, E.; Hudlicky, T. J. Org. Chem. 1988, 53, 1953-1957.
  13. Selective reduction of a,b-unsaturated esters in the presence of olefins. Hudlicky, T.; Sinai–Zingde, G.; Natchus, M. G. Tetrahedron Lett. 1987, 28, 5287-5290.
  14. System oriented design of triquinanes: stereocontrolled synthesis of pentalenic acid and pentalenene. Hudlicky, T.; Sinai–Zingde, G.; Natchus, M. G.; Ranu, B. C.; Papadopoulos, P. Tetrahedron 1987, 43, 5865-5721.
  15. Stereocontrolled total synthesis of pentalenenes via [2+3] and [4+1] cyclopentene annulation methodologies. Hudlicky, T.; Natchus, M. G.; Sinai–Zingde, G. J. Org. Chem. 1987, 52, 4641-4644.
  16. General method of synthesis for natural long-chain b-diketones. Barbieri, G.; Seoane, G.; Trabazo, J. L.; Riva, A.; Umpierrez, F.; Radesca, L.; Tubio, R.; Kwart, L. D.; Hudlicky, T. J. Nat. Prod. 1987, 50, 646-647.
  17. Menthyl 2-bromocrotonate and menthyl 4-bromo-crotonate: reagents for chiral vinylogous Darzen and Reformatsky reactions. Hudlicky, T.; Radesca, L.; Rigby, H. L. J. Org. Chem. 1987, 52, 4397-4399.
  18. Mild methodology for [4+1] pyrroline annulation. Second-generation synthesis of pyrrolizidine alkaloids. Hudlicky, T.; Sinai–Zingde, G.; Seoane, G. Synth. Commun. 1987, 17, 1155-1163.
  19. [2+3] Cyclopentene annulation and other trimethylsilyl iodide-mediated rearrangement pathways of vinylcyclopropanes. Fleming, A.; Sinai–Zingde, G.; Natchus, M.; Hudlicky, T. Tetrahedron Lett. 1987, 28, 167-170.
  20. New vinylcyclopropanation methodology and reagents for potential [2+3] cyclopentene, dihydrofuran, and pyrroline annulations. Hudlicky, T.; Radesca, L.; Luna, H.; Anderson, F. E. J. Org. Chem. 1986, 51, 4746-4748.
  21. General methodology for the topologically selective preparation of linear and nonlinear tricyclopentanoids of hirsutane and isocomene type via a Claisen rearrangement/cyclopentene annulation sequence. Total synthesis of (±)-epiisocomene. Hudlicky, T.; Kwart, L. D.; Tiedje, M. H.; Ranu, B. C.; Short, R. P.; Frazier, J. O. Rigby, H. L. Synthesis 1986, (9), 716-727.
  22. Topological selectivity in the intramolecular [4+1] pyrroline annulation. Formal total stereospecific synthesis of (±)-supinidine, (±)-isoretronecanol and (±)-trachelanthamidine. Hudlicky, T.; Frazier, J. O.; Seoane, G.; Tiedje, M. H.; Seoane, A.; Kwart, L. D.; Beal, C. J. Am. Chem. Soc. 1986, 108, 3755-3762.
  23. Total synthesis of (±)-epiisocomenes by hydrogenation of Chaterjee’s ketone. Kwart, L. D.; Tiedje, M.; Frazier, J. O.; Hudlicky, T. Synth. Commun. 1986, 16, 393-399.
  24. Claisen/ozonolysis alternative to alkylation of enolate anions. Synthesis of 1,4-dicarbonyl compounds. Carman, L.; Kwart, L. D.; Hudlicky, T. Synth. Commun. 1986, 16, 169-182.
  25. Studies in the regioselectivity of the vinylogous Reformatsky reaction with ambident electrophiles: reversibility, mechanism, and synthetic utility. Hudlicky, T.; Natchus, M. G.; Kwart, L. D.; Colwell, B. L. J. Org. Chem. 1985, 50, 4300-4306.
  26. Heteroatom cyclopentene annulation. Synthesis of a guaiane ring system. Hudlicky, T.; Govindan, S. V.; Frazier, J. O. J. Org. Chem. 1985, 50, 4166-4171.
  27. Intramolecular [4+1] pyrroline annulation approach to pyrrolizidine alkaloids. Formal total synthesis of (±)-supinidine. Hudlicky, T.; Frazier, J. O.; Kwart, L. D. Tetrahedron Lett. 1985, 26, 3523.
  28. Intramolecular Simmons–Smith reaction and other synthetic alternatives to cyclopropanation of dienic diazoketones. Parallel decomposition pathways of a sterically congested diazo ketone and its vinylcyclopropane under thermal, photolytic, acid-catalyzed and radical release conditions. Hudlicky, T.; Ranu, B. C.; Naqvi, S. M.; Srnak, A. J. Org. Chem. 1985, 50, 123-127.
  29. Stereocontrolled total synthesis of isocomene sesquiterpenes. Ranu, B. C.; Kavka, M.; Higgs, L. A.; Hudlicky, T. Tetrahedron Lett. 1984, 25, 2447-2450.
  30. Regioselectivity in the Reformatsky reaction of 4-bromocrotonate. Role of the catalyst and the solvent in the normal vs. abnormal modes of addition to carbonyl substrates. Rice, L. E.; Boston, M. C.; Finklea, H. O.; Suder, B. J.; Frazier, J. O.; Hudlicky, T. J. Org. Chem. 1984; 49, 1845-1948.
  31. Studies in Cephalotaxus alkaloids. Stereospecific total synthesis of homoharringtonine. Hiranuma, S.; Shibata, M.; Hudlicky, T. J. Org. Chem. 1983, 48, 5321-5326.
  32. Intramolecular cyclopentene annulation. 3. Synthesis and carbon-13 nuclear magnetic resonance spectroscopy of bicyclic cyclopentene lactones as potential perhydroazulene and/or monoterpene synthons. Hudlicky, T.; Govindan, S. V.; Reddy, D. B.; Kulp, T.; Still, B.; Sheth, J. P. J. Org. Chem. 1983, 48, 3422-3428.
  33. General method of synthesis of cyclopentanoid terpenic acids. Stereocontrolled total syntheses of (±)-isocomenic acid and (±)-epiisocomenic acid. Short, R. P.; Revol, J. M.; Ranu, B. C.; Hudlicky, T. J. Org. Chem. 1983, 48, 4453-4461.
  34. Two topologically distinct total syntheses of (±)-sarkomycin. Govindan, S. V.; Hudlicky, T.; Koszyk, F. J. J. Org. Chem. 1983, 48, 3581-3583.
  35. Synthesis of homoharringtonine and its derivative by partial esterification of cephalotaxine. Hiranuma, S.; Hudlicky, T. Tetrahedron Lett. 1982, 23, 3431-3134.
  36. Terpenic acids by cyclopentane annulation of exocyclic dienes. Synthesis of triquinane portion of retigeranic acid. Hudlicky, T.; Short, R. P. J. Org. Chem. 1982, 47, 1522-1527.
  37. Aluminum oxide catalyzed isomerization of acylated cycloalkenes. Hudlicky, T.; Srnak, T. Tetrahedron Lett. 1981, 22, 3351-3354.
  38. A total synthesis of (±)-isocomene and (±)-b-isocomene by an intramolecular ene reaction. Oppolzer, W.; Bättig, K.; Hudlicky, T. Tetrahedron 1981, 37, 4359-4364.
  39. Intramolecular cyclopentene annulation. 2. Synthesis and carbon-13 nuclear magnetic resonance spectroscopy of bicyclo[4.3.0]non-7-en-2-ones. Hudlicky, T.; Koszyk, F. J.; Dochwat, D. M.; Cantrell, G. C. J. Org. Chem. 1981, 46, 2911-2915.
  40. Improved synthesis and characterization of Pictet–Spengler adducts of phenylpyruvic acid and biogenic amines. Hudlicky, T.; Kutchan, T. M.; Shen, G.; Sutliff, V.; Coscia, C. J. J. Org. Chem. 1981, 46, 1738-1741.
  41. Cyclopentene annulation via intramolecular addition of diazoketones to 1,3-dienes. Applications to the synthesis of cyclopentanoid terpenes. Hudlicky, T.; Koszyk, F. J.; Kutchan, T. M.; Sheth, J. P. J. Org. Chem. 1980, 45, 5020-5027.
  42. Selectivity in retro-ene vs. cyclopentene rearrangements of cis-methylvinylcyclopropane. Hudlicky, T.; Koszyk, F. J. Tetrahedron Lett. 1980, 21, 2487-2490.
  43. Total synthesis of (±)-hirsutene. Hudlicky, T.; Kutchan, T. M.; Wilson, S. R.; Mao, D. T. J. Am. Chem. Soc. 1980, 102, 6351-6353.
  44. Total synthesis of (±)-filifolone. Hudlicky, T.; Kutchan, T. Tetrahedron Lett. 1980, 21, 691-692.
1980s
  1. Intramolecular carbenoid addition to 1,3-dienes. Synthesis of cyclopentene annulated ring systems. Hudlicky, T.; Sheth, J. P.; Gee, V.; Barnvos, D. Tetrahedron Lett. 1979, 20, 4889.
  2. Synthesis of dienic acids. Application of the Arndt–Eistert reaction to unsaturated diazoketones. Hudlicky, T.; Sheth, J. P. Tetrahedron Lett. 1979, 20, 2667-2670.
  3. The total synthesis of (±)-isocomene by an intramolecular ene reaction. Preliminary communication. Oppolzer, W.; Bättig, K.; Hudlicky, T. Helv. Chim. Acta 1979, 62, 1493-1496.
  4. Short synthesis of eburnamonine via b-oxycyclopropylcarbonyl and related intermediates. Wenkert, E.; Hudlicky, T.; Showalter, H. J. Am. Chem. Soc. 1978, 100, 4893-4894.
  5. Reactions of isatin dimethyl ketal and its ethyl imino ether with methyllithium. Wenkert, E.; Hudlicky, T. Synth. Commun. 1977, 7, 541-547.
  6. The SRN1 mechanism in heteroaromatic nucleophilic substitution. Photostimulation and entrainment of the reaction of lithioacetone with 2-chloroquinoline. Hay, J. V.; Hudlicky, T.; Wolfe, J. F. J. Am. Chem. Soc. 1975, 97, 374-377.
  7. Selective C-alkylation of phenylacetylureas through 1,3,5-trialkali salt intermediates. Taylor, J. D.; Trimitsis, G. B.; Hudlicky, T.; Wolfe, J. F. J. Org. Chem. 1973, 38, 1236-1238.
  8. Reactions of dialkali salts of benzoylacetone with 2-chloroquinoline. Evidence for an SRN1 mechanism in heteroaromatic nucleophilic substitution. Greene, J. C.; Wolfe, J. F.; Hudlicky, T. J. Org. Chem. 1972, 37, 3199-3200.
1970s

Reviews, chapters & books

(*denotes publications by invitation)

  1. Morphine Alkaloids: History, biology, and synthesis. Wicks, C.; Rinner, U.; Hudlicky, T. in The Alkaloids, Knoelker, H.-J., Ed. 2020, Volume X, pp XXXX.
  2. Enzymatic dihydroxylation of aromatic compounds: Nature’s unique reaction and its impact on the synthesis of natural products. Bedard, K.; Hudlicky, T. in Strategies and tactics in Organic Synthesis, Harmata, M., Ed., 2020, Volume X, pp xxx-xxx
  3. Tetrodotoxin: History, Biology, and synthesis. Makarova, M.; Rycek, L.; Hajicek, J.; Baidilov, D.; Hudlicky, T. Chem. Int. Ed. 2019, 58, 18338-18387.
  4. *The benefits of unconventional methods in the total synthesis of natural products. Hudlicky, T. ACS Omega 2018, 3,17326-17340. [Invited Perspective]
  5. *Applications of the Wittig-Still rearrangement in organic synthesis. Rycek, L.; Hudlicky, T. Angew. Chem. Int. Ed. 2017, 56, 6022-6066.
  6. *Galanthamine. Rinner, U.; Dank, C.; Hudlicky, T. in Targets in Heterocyclic Systems-Chemistry and properties, Attanasi, O. A.; Merino, P.; Spinelli, D., Eds., 2016, 20, 283-315.
  7. *Advances in N- and O-demethylations of opiates. Machara, A.; Hudlicky, T. in Targets in Heterocyclic Systems-Chemistry and properties, Attanasi, O. A.; Merino, P.; Spinelli, D., Eds., 2016, 20, 113-138.
  8. *Contributions of Ernest Wenkert to the use of cyclopropanes in synthesis — impact, reflections and recollections. Hudlicky, T. Isr, J. Chem. 2016, 56, 540-552.
  9. Synthesis of Amaryllidaceae constituents and unnatural derivatives. Ghavre, M.; Froese, J.; Pour, M.; Hudlicky, T. Angew. Chem. Int. Ed. 2016, 55, 5642-5691.
  10. *Recent advances in process development for opiate-derived pharmaceutical agents. Hudlicky, T. Can. J. Chem. 2015, 93, 492-501.
  11. *The quest for a practical synthesis of morphine alkaloids and their derivatives by chemoenzymatic methods. Reed, J. W.; Hudlicky, T. Acc. Chem. Res. 2015, 48, 674-687 (Special Issue on Synthesis, Wender, P., Guest editor).
  12. *Rearrangements of vinylcylopropane, divinylcyclopropane, and related systems. Vshyvenko, S.; Reed, J. W.; Hudlicky, T.; Piers, E. In Comprehensive Organic Synthesis, 2nd Ed.; Knochel, P. and Molander, G., Eds., Elsevier, 2014; Vol. 5, pp 999-1076.
  13. *A short history of the discovery and development of naltrexone and other derivatives. Varghese, V.; Hudlicky, T. In Natural Products in Medicinal Chemistry, S. Hanessian, Ed.; Methods and Principles in Medicinal Chemistry; Wiley-VCH: Weinheim, 2014; Chapter 6, pp 225-250.
  14. *Adams, D. R.; Hudlicky, T. Retigeranic Acid, In Total Synthesis of Natural Products: At the Frontiers of Organic Chemistry; Li, J. J.; Corey, E. J., Eds.; Springer-Verlag: Heidelberg, 2013, Chapter 10, pp 235-258.
  15. *Synthesis of morphine alkaloids and derivatives. Rinner, U.; Hudlicky, T. Alkaloid Synthesis; Topics in Current Chemistry; Springer-Verlag: Berlin, 2012; Vol. 309, pp 33-66.
  16. *Chemoenzymatic synthesis of inositols, conduritols, and cyclitol analogues. Duchek, J.; Adams, D. R.; Hudlicky, T. Chem. Rev. 2011, 111, 4223-4258.
  17. *Introduction to enzymes in synthesis. Hudlicky, T. Chem. Rev. 2011, 111, 3995-3997.
  18. *From discovery to application: 50 years of the vinylcyclopropane–cyclopentene rearrangement and its impact on the synthesis of natural products. Hudlicky, T.; Reed, J. W. Angew. Chem. Int. Ed. 2010, 49, 4864-4876.
  19. *Applications of biotransformations and biocatalysis to complexity generation in organic synthesis. Hudlicky, T.; Reed, J. W. Chem. Soc. Rev. 2009, 38, 3117-3132.
  20. *Celebrating 20 years of SYNLETT. On the merits of biocatalysis and the impact of arene cis-dihydrodiols on enantioselective synthesis. Hudlicky, T.; Reed, J. W. Synlett, 2009, 685-703.
  21. Hudlicky, T.; Reed, J. W. The Way of Synthesis: Evolution of Design and Methods for Natural Products; Wiley–VCH, Weinheim, Germany, 2007.
  22. Recent progress in the synthesis of morphine alkaloids. Zezula, J.; Hudlicky, T. Synlett 2005, 388-405.
  23. Synthesis of Amaryllidaceae constituents — an update. Rinner, U.; Hudlicky, T. Synlett 2005, 365-387.
  24. Book review: Bommarius, A. S.; Riebel, B. R. Biocatalysis. Fundamentals and Applications; Wiley–VCH: Weinheim, Germany, 2004. Hudlicky, T. J. Nat. Prod. 2005, 68, 150.
  25. *Biocatalytic synthesis of alkaloids and carbohydrates: an update. Hudlicky, T. In Enzymes in Action; Zwanenburg, B. Ed.; NATO ASI Series; Kluwer Academic, Dordrecht, 2000; pp 311-321.
  26. *Recent progress in efficient syntheses of Amaryllidacae and morphine alkaloids. Hudlicky, T. J. Heterocyclic Chem. 2000, 37, 535-539.
  27. Morphine synthesis and biosynthesis—an update. Novak, B. H.; Hudlicky, T.; Reed, J. W.; Mulzer, J.; Trauner, D. Curr. Org. Chem. 2000, 4, 343-362.
  28. *Enzymatic dihydroxylation of aromatics in enantioselective synthesis: expanding asymmetric methodology. Hudlicky, T.; Gonzalez, D.; Gibson, D. T. Aldrichimica Acta 1999, 32, 35.
  29. * Natural product synthesis via biocatalysis: an essay of the merits of multidisciplinary ventures. Hudlicky, T. J. Braz. Chem. Soc. 1998, 9, 313-318.
  30. Green chemistry alternatives for the processing of aromatic compounds. Tandem strategies in biocatalysis and synthesis. Hudlicky, T. In Green Chemistry: Frontiers in Benign Chemical Synthesis and Processes; Anastas, P. T., Williamson, T. C., Eds.; Oxford University Press: Oxford, 1998; Chapter 10, pp 166-177.
  31. The story of morphine structure elucidation: one hundred years of deductive reasoning. Butora, G.; Hudlicky, T. Organic Synthesis: Theory and Applications; Hudlicky, T., Ed.; JAI Press: Stamford, CT, 1998; Vol. 4, pp 1-51.
  32. *The Cephalotaxus alkaloids—a review. Miah, M. A. J.; Hudlicky, T.; Reed, J. W. In The Alkaloids: Chemistry and Biology; Cordell, G. A., Ed.; Academic Press: San Diego, 1998; Vol. 51, pp 199-269.
  33. *Modern methods of monosaccharide synthesis from non-carbohydrate sources. Hudlicky, T.; Entwistle, D. A.; Pitzer, K. K.; Thorpe, A. J. Chem. Rev. 1996, 96, 1195-1220.
  34. *Formation of seven-membered rings: divinylcyclopropane–cycloheptadiene rearrangement. Hudlicky, T.; Fan, R. L.; Becker, D. A.; Kozhushkov, S. In Carbocyclic Three-membered Ring Compounds; Houben–Wyel, 1996; Vol. E 17c, p. 2589.
  35. *Formation of five-membered rings: vinylcyclopropane–cyclopentene rearrangement. Hudlicky, T.; Becker, D. A.; Fan, R. L.; Kozhushkov, S. In Carbocyclic Three-membered Ring Compounds; Houben–Wyel, 1996; Vol. E 17c, p. 2538.
  36. *A historical perspective of morphine syntheses. Hudlicky, T.; Butora, G.; Fearnley, S. P.; Gum, A. G.; Stabile, M. R. In Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed.; Elsevier: Amsterdam, 1996; Vol. 18 [Stereoselective Synthesis (Part K)], pp 43-154.
  37. *Environmentally efficient management of aromatic compounds. Economic perspectives of biocatalytic conversion of aromatics to optically pure synthons for the pharmaceutical industry. Hudlicky, T. In Green Chemistry. Designing Chemistry for the Environment; Anastas, P. T., Williamson, T. C., Eds.; ACS Symposium Series 626; American Chemical Society: Washington, D. C., 1996; Chapter 14, pp 180-197.
  38. *Design constraints in practical syntheses of complex molecules: current status, case studies with carbohydrates and alkaloids, and future perspectives. Hudlicky, T. Chem. Rev. 1996, 96, 3-30.
  39. *An evolutionary perspective of microbial oxidations of aromatic compounds in enantioselective synthesis: history, current status, and perspectives. Hudlicky, T.; Reed, J. W. In Advances in Asymmetric Synthesis; A. Hassner, Ed.; JAI Press: London, 1995; Vol. 1, pp 271-312.
  40. Enantioselective synthesis of alkaloids and carbohydrates via chemoenzymatic methods. Hudlicky, T. Pure Appl. Chem. 1994, 66, 2067–2070.
  41. The use of arene cis-diols in synthesis. Brown, S. M.; Hudlicky, T. In Organic Synthesis: Theory and Applications; T. Hudlicky, ed.; JAI Press: London, 1993; Vol. 2, pp 113-176.
  42. Modern synthetic design: symmetry, simplicity, efficiency, and art. Hudlicky, T.; Natchus M. G. In Organic Synthesis: Theory and Applications; Hudlicky, T., Ed.; JAI Press: London, 1993; Vol. 2, pp 1-25.
  43. Efficient synthesis of optically active carbohydrates and other oxygenated compounds through bio-oxidation of chlorinated aromatics. Hudlicky, T. In Enzymes in Organic Synthesis; NATO ASI Series C; S. Servi, Ed.; Kluwer Academic: Boston, 1992; Vol. 381, pp 123-134.
  44. Divinylcyclopropane–cycloheptadiene rearrangement. Hudlicky, T.; Fan, R.; Reed, J. W.; Gadamasetti, K. G. Organic Reactions 1992, 41, 1-133.
  45. Hudlicky, T.; Cebulak, M. Cyclitols and their Derivatives: A Handbook of Physical, Spectral, and Synthetic Data; VCH: New York, 1993.
  46. Enzymatic hydroxylation of arenes and symmetry considerations in efficient synthetic design of oxygenated natural products. Hudlicky, T.; Fan, R.; Luna, H.; Olivo, H.; Price, J. (Proceedings of IUPAC Congress on Enzymes in Organic Synthesis, New Dehli, India, January 1992.) Pure Appl. Chem. 1992, 64, 1109-1113; Ind. J. Chem. 1993, 32B, 154-158.
  47. *Rearrangements of vinylcyclopropanes and related systems. Hudlicky, T.; Reed, J. W. In Comprehensive Organic Synthesis: Selectivity, Strategy & Efficiency in Modern Organic Chemistry; B.M. Trost, Ed.; Pergamon Press: Oxford, 1991; Vol. 5, p. 899.
  48. *Anionic approaches to the construction of cyclopentanoids. Hudlicky, T.; Price, J. D. Chem. Rev. 1989, 89, 1467-1486.
  49. *Synthesis of natural products containing five-membered rings. An evolution of general methodology. Hudlicky, T.; Rulin, F.; Lovelace, T. C.; Reed, J. W. In Studies in Natural Products Chemistry; Atta-ur-Rahman, ed.; Elsevier Science, 1989; Vol. 3, Part B, pp 3-72.
  50. *Use of cyclopropanes and their derivatives in organic synthesis. Wong, H. N. C.; Hon, M. Y.; Tse, C. W.; Yip, Y. Ch.; Tanko, J.; Hudlicky, T. Chem. Rev. 1989, 89, 165-198.
  51. *[2+3] Carbo- and heterocyclic annulation in the design of complex molecules. Hudlicky, T.; Fleming, A.; Lovelace, T.; Seoane, G.; Gadamasetti, K.; Sinai-Zingde, G. In Strain and its Implications in Organic Chemistry; A. de Meijere, S. Blechert, Eds.; NATO ASI Series C, Kluwer Academic: Boston, 1989; Vol. 274; pp 109-115.
  52. *Synthesis of cephalotaxine alkaloids. Hudlicky, T.; Kwart, L. D.; Reed, J. W. In Akaloids: Chemical and Biological Perspectives; S.W. Pelletier, Ed.; John Wiley: New York, 1987; Vol. 5, Chapter 5, pp 639-690.
  53. General methodology for the synthesis of linear and nonlinear triquinane sesquiterpenes: coriolin, pentalenene, and pentalenic acid. Hudlicky, T.; Natchus, M. G.; Sinai-Zingde G., Ranu, B. C.; Rigby, H. L., Andre, T. In Progress in Terpene Chemistry; Joulain, D., Ed.; Proceedings of the Conference on Terpene Chemistry, Grasse (France); Editions Frontières: Gif-sur-Yvette, France, 1986; pp 221-236.
  54. *The vinylcyclopropane-cyclopentene rearrangement. Hudlicky, T.; Kutchan, T. M.; Naqvi, S. M. Organic Reactions 1985, 33, 247-335.
  55. Formation of carbon–halogen bonds. Hudlicky; M.; Hudlicky T. In The Chemistry of Halides, Pseudo-halides, and Azides; Patai, S.; Rappoport, Z., Eds; The Chemistry of Functional Groups, Supplement D; John Wiley: New York, 1983; Vol. 2, Chap 22, pp 1021-1172.
  56. *[Articles on terpenes, diterpenes, squalene, and isoprene.] Hudlicky, T. In The Encyclopedia of Science and Technology; McGraw–Hill, 1982.

Editorships

  1. Hudlicky, T. Guest Ed. Chemical Reviews. Enzymes in Synthesis [topical issue], 2011, 111.
  2. Hudlicky, T., Guest Ed. Current Organic Chemistry—Asymmetric Synthesis 2004, 8 (14).
  3. Hudlicky, T., Guest Ed. Current Organic Chemistry—Asymmetric Synthesis 2003, 7 (17).
  4. Hudlicky, T., Guest Ed. Current Organic Chemistry—Asymmetric Synthesis 2002, 6 (4).
  5. Hudlicky, T., Ed. Organic Synthesis: Theory and Applications; JAI Press: Stamford, CT, 2001; Vol. 5.
  6. Hudlicky, T., Guest Ed. Current Organic Chemistry—Asymmetric Synthesis 2001, 5 (4).
  7. Hudlicky, T., Guest Ed. Current Organic Chemistry—Asymmetric Synthesis 2000, 4 (3).
  8. Hudlicky, T., Guest Ed. Current Organic Chemistry—Asymmetric Synthesis 1999, 3 (3).
  9. Hudlicky, T., Guest Ed. Current Organic Chemistry—Asymmetric Synthesis 1998, 2 (3).
  10. Hudlicky, T., Editor. Organic Synthesis: Theory and Applications; JAI Press: Stamford, CT, 1998; Vol. 4.
  11. Hudlicky, T., Guest Ed. Current Organic Chemistry—Asymmetric Synthesis 1997, 1 (1).
  12. Hudlicky, T., Ed. Organic Synthesis: Theory and Applications; JAI Press: Greenwich, CT, 1996; Vol. 3.
  13. Hudlicky, T., Ed. Organic Synthesis: Theory and Applications; JAI Press: Greenwich, CT, 1993; Vol. 2.
  14. Hudlicky, T., Ed. Organic Synthesis: Theory and Applications; JAI Press: Greenwich, CT, 1989; Vol. 1.

Patents

(listed by patent families)

1.       Synthesis of sugars from substituted and unsubstituted arenediols. T. Hudlicky

  • US 5200516, patent granted Apr 6, 1993

2.       Synthesis of cyclitols from substituted arenediols. T. Hudlicky

  • US 5306846, patent granted Apr 26, 1994
  • EP 477359, patent granted Jul 5, 1995
  • CA 2060506, patent granted Jun 12, 2007

3.       Syntheses of D-chiro-3-inosose and (+)-D-chiro-inositol. T. Hudlicky; M. Mandel

  • US 5563281, patent granted Oct 8, 1996
  • US 5578738, patent granted Nov 26, 1996
  • US 5600014, patent granted Feb 4, 1997
  • US 5602263, patent granted Feb 11, 1997
  • US 5602287, patent granted Feb 11, 1997
  • US 5633412, patent granted May 27, 1997
  • AU 693075, patent granted Jun 25, 1998
  • EP 663915, patent granted Dec 4, 2002
  • EP 1225175, patent granted Mar 30, 2005
  • CA 2146353, patent granted Apr 17, 2007

4.       Method for preparing 2,3-O-isopropylidien-L-erythruronolactone. T. Hudlicky; M. Mandel

  • US 5442079, patent granted Aug 15, 1995
  • EP 698026, patent granted Jul 15, 1998
  • CA 2162606, patent granted Nov 22, 2005

5.       Sterospecific synthesis of four stereoisomers of by microbial oxygenation of chlorobenzene with Pseudomonas putida. T. Hudlicky

  • US 5488166, patent granted Jan 30, 1996
  • US 5488167, patent granted Jan 30, 1996
  • EP 724562, patent granted Jun 3, 1998
  • CA 2174431, patent granted Dec 6, 2005
  • JP 3783730, patent granted Jun 7, 2006
  • JP 4224049, patent granted Feb 12, 2009

6.       Synthesis of conduritol epoxides and aziridines and methods of using such to synthesize higher disaccharides. T. Hudlicky

  • US 5834606, patent granted Nov 10, 1998
  • EP 765336, patent granted May 2, 2002
  • CA 2193097, patent granted Dec 4, 2007
  • JP 4064451, patent granted Mar 19, 2008

7.       Synthesis of (+)-pancratistatin. T. Hudlicky, X. Tian, K. Königsburger

  • US 5627280, patent granted May 6, 1997
  • EP 809643, patent granted Oct 17, 2001
  • CA 2213253, patent granted Jul 11, 2006

8.       Preparation of pancratistatins and processes for their production. T. Hudlicky, K. Königsberger, S. D. McLamore, R. Maurya

  • US 5777137, patent granted Jul 7, 1998

9.       Process for preparing a morphinan derivative. T. Hudlicky, G. Butora

  • US 6242604, patent granted 2001

10.    Methods for N-demethylation of morphine and tropane alkaloids. R. J. Carroll, H. Leisch, T. Hudlicky

  • US 7935820, patent granted May 3, 2011
  • AU 2008271864, patent granted Feb 28, 2013
  • JP 5370865, patent granted Dec 18, 2013
  • WO 2009003272, application published, 2009
  • CA 2692433, patent published, 2009
  • EP 2170898, patent published, 2009

11.    Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids. R. J. Carroll; H. Leisch; T. Hudlicky; D. P. Cox

  • US 7999104, patent granted Aug 16, 2011
  • AU 2008271862, patent granted Jul 5, 2012
  • EP 2170897, patent granted Aug 21, 2013
  • JP 5462156, patent granted Sep 30, 2014
  • CN 101801978, patent granted 6 Nov 2013
  • US 20090005565, application published, 2009
  • WO 2009003270, application published, 2009
  • CA 2692426, application published, 2009
  • AU 2008271862, application published, 2009

12.    Conversion of thebaine to morphine derivatives. R. J. Carroll; H. Leisch; T. Hudlicky

  • US 7928234, patent granted Apr 19, 2011
  • WO 2009003271, application published, 2009
  • US 20090005563, application published, 2009
  • AU 2008271863, application published, 2009
  • CA 2692429, application published, 2009
  • EP 2173754, application published, 2010

13.    Process and compounds for the manufactrue of oseltamivir and analogs thereof, and new antiviral agents. T. Hudlicky

  • US 8716333 patent granted May 6, 2014
  • WO 2009137916, application published, 2009
  • US 20110201577, application published, 2011

14.    Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids. T. Hudlicky, R. J. Carroll, H. Leisch, A. Machara, L. Werner; M. A. Endoma-Arias

  • US 8962841, patent granted Feb 24, 2015
  • US 7999104, patent granted Aug 16, 2011
  • US 20150152120, application, Jun 4, 2015

15.    C-1 analogs of pancratistatin and 7-deoxypancratistatin and processes for their preparation. T. Hudlicky, J. Collins

  • US 8703792, patent granted Apr 22, 2014, 2014
  • WO 2010121369, application published, 2010
  • CA 2758231, application published, 2010
  • AU 2010239059, application published, 2011
  • EP 2421868, application published, 2012
  • US 20120046465, application published, 2012

16.    Processes for the preparation of morphinane and morphinone compounds. T. Hudlicky, R. Carroll, H. Leisch, A. Machara, L. Werner, D. R. Adams

  • US 8853401, patent granted Oct 7, 2014
  • WO 2010069054, application published, 2010
  • CA 2747565, application published, 2010
  • EP 2376498, application published, 2011
  • US 20110306629, application published, 2011

17.    Preparation of benzodioxoxole derivatives for treatment of influenza. T. Hudlicky; L. Werner; A. Machara

  • US 8716333, patent granted May 6, 2014
  • WO 2011047466, application published, 2011
  • CA 2777187, application published, 2011
  • US 20120252890, application published, 2012

18.    Processes and intermediates in the preparation of morphine analogs via N-demethylation of N-oxides using cyclodehydrating agents. T. Hudlicky; L. Werner; M. Wernerova; M. A. Endoma-Arias; A. Machara

  • US 8957072, patent granted Feb 17, 2015
  • US 9045497, patent granted Jun 2, 2015
  • WO 2012149633, application published, 2012
  • CA 2833283, application published, 2012
  • US 20120283443, application published, 2012
  • EP 2705043, application published, 2014

19.    Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer. T. Hudlicky; A. Machara

  • US 8946214, patent granted Feb 3, 2015
  • US 9108967, patent granted Aug 18, 2015
  • WO 20121511669, application published, 2012
  • US 20120283444, application published, 2012
  • CA 2833282, application published 2012
  • AU 2012253188, application published 2012
  • EP 2705040, application published 2014
  • US 20150094471, application published 2015

20.    Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans. T. Hudlicky; M. A. Endoma-Arias

  • US 8981098, patent granted Mar 17, 2015
  • CA 2863242, application published, 2013
  • AU 2013214667, application published, 2013
  • EP 2809674, application published, 2014
  • US 20140371458, application published, 2014
  • WO 2013113120, application published, 201320.

21.    Methods and apparatus for time-pulsed chromatography. T. Hudlicky; I. D. Brindle; M. A. Endoma-Arias (filed 2013)

  • US 20140326670 A1, application published, Nov 6, 2014
  • CA 22851112 A1, application, Nov 6, 2014

22.    Methods for the preparation of hydromorphone from thebaine via oripavine. T. Hudlicky, M. A. Endoma-Arias, B. A. Murphy, I. Snajdr, A. Machara.

  • US 20150225419 A1, application published, Aug 13, 2015.
  • CA 2881229 A1, application, Aug 7, 2015.

23.    Processes for preparing morphine compounds. V. Varghese; T. Hudlicky (filed Feb 24, 2014)

  • US 9126965, patent granted, 8 Sep 2015.
  • CA 2882694 A1, application, 2015.