Chemistry

Chair

Costa Metallinos

Professors Emeriti

Martin S. Gibson, J.S. Hartman, Richard R. Hiatt, Jack M. Miller, David C. Moule

Professors

Jeffrey Atkinson, Ian D. Brindle, Tomas Hudlicky, Andrew G. Reynolds, Stuart M. Rothstein, Art van der Est

Associate Professors

Travis Dudding, Heather L. Gordon, Costa Metallinos, Melanie Pilkington, Georgii Nikonov, Hongbin (Tony) Yan

Assistant Professors

Martin T. Lemaire

Adjunct Professors

Christopher H. Marvin, Victor Snieckus

Adviser

Art van der Est

Laboratory Co-ordinator/Instructor

Sergio Paone, Paul Zelisko

Senior Demonstrator

Roger McLaughlin

Co-ordinator, Analytical Services

Tim R. B. Jones

NMR Technologist

Razvan Simionescu

Director, Co-operative Programs

Cindy Dunne

Co-operative Program Co-ordinator

Stuart M. Rothstein

General Information

Administrative Assistant

Christine Skorski

905-688-5550, extension 3406

Mackenzie Chown E206

brocku.ca/chemistry

Chemistry is the study of matter and its interactions with various forms of energy. Brock students are involved in the analysis, synthesis and purification of substances, determining their structures and properties and explaining the mechanisms of processes.

Our programs stress chemical principles and practice through research in organic, inorganic, analytical, physical and theoretical chemistry, with a strong emphasis on the interdisciplinary fields of bio-inorganic and bio-organic chemistry and chemical biophysics. Research interests of the department include development of new chiral ligands, organometallic reagents, and methods for asymmetric synthesis, green chemistry including bacterial dioxygenase-mediated degradation of aromatics, new approaches in natural product synthesis emphasizing morphine alkaloids, design and synthesis of fluorinated inhalation anesthetic agents and unnatural oligo-saccharide conjugates, ligand design and crystal engineering aimed at self-assembly of novel molecule-based materials, organic electrochemistry, energetics of photosynthesis studied by time-resolved electron spin resonance of short-lived paramagnetic intermediates, nuclear magnetic resonance spectroscopy, organometallic mass spectrometry, quantum and computational chemistry, pesticide and trace element analysis, protein affinity labelling and protein-lipid interactions, and structure-activity correlations of anticancer pharmaceuticals.

The Honours program in Chemistry is designed to give the student a broad knowledge of chemistry as well as depth in areas in which the student is most interested. A research project must be successfully completed and a thesis written as part of the requirements for an Honours degree. The Honours program and certain combined Honours programs listed below, when taken with CHEM electives, satisfy the requirements for membership in the Chemical Institute of Canada and are the normal requirements for admission to graduate school in chemistry.

The Chemistry Co-op program combines academic and work terms over a four and one half year period. Students spend two years in an academic setting, where they acquire the necessary background prior to taking the first work placement. Successful completion of courses in the core areas of Chemistry provides the necessary academic background for the work experience. In addition to the current fees for courses in academic study terms, Chemistry Co-op students are assessed an annual administrative fee (see the Schedule of Fees).

Eligibility to continue in the Co-op program is based on the student's major average and non-major average. A student with a minimum 70 percent major average and a minimum 60 percent non-major average will be permitted to continue. A student with a major average lower than 70 percent will not be permitted to continue in the Chemistry Co-op program, but may continue in the non Co-op Chemistry stream. For further information, see the Co-op Programs section of the Calendar, and contact the Department of Chemistry.

The requirement for graduation with a Chemistry (Honours) degree is a minimum 70 percent major average and a minimum 60 percent non-major average. The Chemistry Co-op program designation will be awarded to those students who have honours standing and who have successfully completed a minimum of twelve months of Co-op work experience.

The equipment available in the Mackenzie Chown Complex is actively used for both teaching and research. Undergraduate students gain hands-on experience in operating modern equipment for separating of complex mixtures, determining molecular structures, and making quantitative measurements. Newer equipment is computer-controlled and is connected to the University's Ethernet backbone. The department also has a variety of computers and UNIX workstations for advanced computation, data interpretation and molecular modelling.

Instrumentation includes 300 and 600 MHz NMR cryospectrometers for high-resolution solution and solids studies. Mass spectrometry facilities include a high resolution machine with EI, CI and FAB ion sources, an ion trap ESI/LC/MS system, a MALDI/TOF spectrometer and two capillary GC/MS facilities. A number of spectroscopic instruments are available in the research laboratories including time-resolved EPR, ICP and ICP/MS, FTIR, UV/Visible, fluorescence cuvette and microplate fluorimeters. There are several chromatography systems for HPLC and capillary GC analysis. This instrumentation is augmented by a range of modern facilities available through the Cool Climate Oenology and Viticulture Institute, which support work in biochemistry, especially work involving proteins, nucleic acids, yeasts and bacteria.

Students should consult the Department Chair when planning years 3 and 4 of the BSc (Honours) and BSc with Major programs, or year 3 of the BSc (Pass) program.

In addition to its own programs, the Chemistry department participates in combined major programs with five other departments/centres and is also a major participant in the Biochemistry, Biotechnology, and Oenology and Viticulture programs.

Program Notes

Honours Program

Year 1

	CHEM 1F92 (see program note 6)
	PHYS 1P21 or 1P91 (recommended; see program note 1)
	one of PHYS 1P22 or 1P92 (recommended; see program note 1)
	MATH 1P01 and 1P02, or MATH 1P05 and 1P06 (recommended)
	one Humanities context credit
	one Social Sciences context credit

Year 2

	CHEM 2P12, 2P20, 2P21, 2P32, 2P42 and 2P63
	one of PHYS 2P02, 2P20, 2P31, 2P50, 2P51
	one-half APCO or MATH credit (see program note 3)
	one elective credit (see program note 2)

Year 3

	CHEM 3P40 and 3P41
	two and one-half credits from CHEM 3P20, 3P21, 3P30, 3P31, 3P51, 3P53, 3P93
	one of PHYS 2P02, 2P20, 2P31, 2P50, 2P51 (not taken in year 2)
	one elective credit (CHEM 3P60 or 3P61 recommended; see program notes 2 and 5)

Year 4

	CHEM 4F90 and 4F91
	one credit from CHEM 3P20, 3P21, 3P30, 3P31, 3P51, 3P53, 3P93 (not taken in year 3)
	one CHEM credit numbered 3(alpha)90 or above
	one elective credit (see program notes 2 and 5)

Chemistry Co-op (Honours only)

Students admitted to the Chemistry Co-op program must follow an approved program pattern. The most common pattern is listed below. For other approved patterns, consult the Co-op Office.

Year 1

	CHEM 1F92 (see program note 6)
	PHYS 1P21 or 1P91 (recommended; see program note 1)
	one of PHYS 1P22 or 1P92 (recommended; see program note 1)
	MATH 1P01 and 1P02, or MATH 1P05 and 1P06 (recommended)
	one Humanities context credit
	one Social Sciences context credit

Year 2

	CHEM 2P12, 2P20, 2P21, 2P32, 2P42 and 2P63
	SCIE 0N90
	one of PHYS 2P02, 2P20, 2P31, 2P50, 2P51
	one-half APCO or MATH credit (see program note 3)
	one elective credit (see program note 2)

Spring/Summer Sessions:

CHEM 0N01 and 2C01

Year 3

Fall Term:

	CHEM 3P20, 3P30, 3P40 and 3P51
	one of PHYS 2P02, 2P20, 2P31, 2P50, 2P51 (not taken in year 2) or one-half elective credit

Winter Term:

CHEM 0N02 and 2C02

Year 4

Fall Term:

CHEM 0N03 and 2C03

Winter Term:

CHEM 3P21, 3P31, 3P41, 3P53, 3P93

Year 5

	CHEM 4F90 and 4F91
	one CHEM credit numbered 3(alpha)90 or above
	two elective credits

Research-oriented Co-op (Honours only)

Year 1

	CHEM 1F92 (see program note 6)
	PHYS 1P21 or 1P91 (recommended; see program note 1)
	PHYS 1P22 or 1P92 (recommended; see program note 1)
	MATH 1P01 and 1P02, or MATH 1P05 and 1P06 (recommended)
	one Humanities context credit
	one Social Sciences context credit

Spring/Summer Sessions:

one-half elective credit

Year 2

	CHEM 2P12, 2P20, 2P21, 2P32, 2P42 and 2P63
	APCO 1P93
	MATH 2F05, or MATH 2P81and 2P82
	one of PHYS 2P02, 2P20, 2P31, 2P50, 2P51
	SCIE 0N90

Spring/Summer Sessions:

CHEM 0N01, 2C01 and 2P98

Year 3

Fall Term:

	CHEM 3P20, 3P30, 3P40 and 3P51
	one of PHYS 2P02, 2P20, 2P31, 2P50, 2P51 (not taken in year 2), or one-half elective credit

Winter Term:

CHEM 0N02 and 2C02

Year 4

Fall Term:

CHEM 0N03, 2C03 and 3P98

Winter Term:

CHEM 3P21, 3P31, 3P41, 3P53 and 3P93

Spring/Summer Sessions:

CHEM 4F90 and 4F91

Year 5

Fall Term:

	one-half CHEM credit numbered 3(alpha)90 or above
	one elective credit (see program note 8)

BSc with Major Program

This program differs from the Honours program in that honours standing is not required for entry into year 4, and year 4 does not include the research project and thesis courses (CHEM 4F90 and 4F91). Combined majors should consult the Chair.

Year 1

	CHEM 1F92 (see program note 6)
	PHYS 1P21 or 1P91 (recommended; see program note 1)
	PHYS 1P22 or 1P92 (recommended; see program note 1)
	MATH 1P01 and 1P02, or MATH 1P05 and 1P06 (recommended)
	one Humanities context credit
	one Social Sciences context credit

Year 2

	CHEM 2P12, 2P20, 2P21, 2P32, 2P42 and 2P63
	one of PHYS 2P02, 2P20, 2P31, 2P50, 2P51
	one-half APCO or MATH credit (see program note 3)
	one elective credit (see program note 2)

Year 3

	CHEM 3P40 and 3P41
	two credits from CHEM 3P20, 3P21, 3P30, 3P31, 3P51, 3P53
	one of PHYS 2P02, 2P20, 2P31, 2P50, 2P51 (not taken in year 2)
	one and one-half elective credits (CHEM 3P60 recommended; see program notes 2 and 5)

Year 4

	one credit from CHEM 3P20, 3P21, 3P30, 3P31, 3P40, 3P51, 3P53 (not taken in year 3)
	three CHEM credits numbered 3(alpha)90 or above
	one elective credit (CHEM 3P60 or 3P61 and either CHEM 3P62 or 3P93 recommended)

Pass Program

Satisfactory completion of the first three years of the Honours program entitles a student to apply for a Pass degree.

Biochemistry

Consult the Biochemistry calendar entry for a listing of courses and program requirements.

Biotechnology

Consult the Biotechnology calendar entry for a listing of courses and program requirements.

Concurrent BSc/BEd

The Department of Chemistry and the Faculty of Education co-operate in offering two Concurrent BSc (Honours)/BEd programs. The Chemistry BSc (Honours)/BEd programs combines the BSc Honours program or BSc Integrated Studies Honours program with the teacher education program for students interested in teaching at the Intermediate/Senior level (grades 7-12) and at the Junior/Intermediate level (grades 4-10). Refer to the Education - Concurrent BSc (Honours)/BEd (Intermediate/Senior) or Education - Concurrent BSc Integrated Studies (Honours)/BEd (Junior/Intermediate) program listings for further information.

Combined Major Program

Combined Honours and Pass programs can be taken in Chemistry/Biology, Chemistry/Computer Science (Honours only), Chemistry/Earth Sciences, Chemistry/Mathematics and Chemistry/Physics. In most of the combined major programs a research project must be successfully completed and a thesis written as part of the requirements for an Honours degree.

Chemistry and Mathematics

Honours

Year 1

	CHEM 1F92 (see program note 6)
	MATH 1P01 and 1P02, or MATH 1P05 and 1P06 (recommended)
	MATH 1P12 and 1P40
	PHYS 1P21 or 1P91 (recommended; see program note 1)
	PHYS 1P22 or 1P92 (recommended; see program note 1)
	one Humanities context credit or Social Sciences context credit

Year 2

	CHEM 2P12 or 2P63
	CHEM 2P20 and 2P42
	CHEM 2P21 or 2P32
	MATH 2P12
	MATH 2F05, or MATH 2P03 and 2P08
	PHYS 2P02 or 2P51
	the Humanities context credit or Social Sciences context credit not taken in year 1

Year 3

	One of CHEM 3P20 and 3P21, CHEM 3P30 and 3P31, CHEM 3P40 and 3P41
	CHEM 3P51 and 3P53
	MATH 2F40, 2P81, 2P82, 3P08 and 3P09

Year 4

	CHEM 4F90 and 4F91
	one of CHEM 3P20 and 3P21, CHEM 3P30 and 3P31, CHEM 3P40 and 3P41 (not taken in Year 3)
	MATH 3P12 and 3P60
	one CHEM or MATH credit numbered 2(alpha)90 or above

Pass

Satisfactory completion of the first three years of the Honours program entitles a student to apply for a Pass degree.

Chemistry and Physics

Honours

Year 1

	CHEM 1F92 (see program note 6)
	MATH 1P01 and 1P02, or MATH 1P05 and 1P06 (recommended)
	PHYS 1P21 or 1P91 (recommended; see program note 1)
	PHYS 1P22 or 1P92 (recommended; see program note 1)
	one Humanities context credit
	one Social Sciences context credit

Year 2

	CHEM 2P12, 2P20, 2P32 and 2P42
	MATH 2F05 (see program note 7)
	PHYS 2P02 or 2P20
	PHYS 2P31, 2P50 and 2P51

Year 3

	CHEM 3P51
	MATH 3P08 and 3P09
	PHYS 3P35 and 3P36
	two credits from CHEM 3P30, 3P31, 3P40, 3P41, 3P53
	one-half elective credit

Year 4

	CHEM 4F90 and 4F91 or PHYS 4F90 and 4F91
	one of CHEM 3P30, 3P31, 3P40, 3P41, 3P53 (not taken in Year 3)
	one CHEM or PHYS credit numbered 2(alpha)90 or above
	one of PHYS 3P02, 3P90, 4P61, 4P70
	one elective credit (see program note 8)

Pass

Satisfactory completion of the first three years of the Honours program entitles a student to apply for a Pass degree.

Minor in Chemistry

Students in other disciplines may obtain a minor in chemistry within their degree program by completing the following courses with a minimum 60 percent average:

	CHEM 1F92
	two CHEM credits numbered 2(alpha)00 or above
	one CHEM credit numbered 3(alpha)00 or above

Brock-Colleges Articulation Agreement

Mohawk College

This agreement allows Brock to admit Mohawk graduates who have a minimum 78 percent overall average in the Chemical Engineering Technology Program to the Honours BSc program in Chemistry. Students automatically receive 6.5 credits towards the Honours BSc program in Chemistry.

Master of Science (MSc) Program

Candidates with either an Honours or a (Pass) BA or a BSc degree in Chemistry, or equivalent, may apply to the Director of the Graduate Studies Office for entry into this program. Candidates holding a Pass degree will be required to take a qualifying year, similar to year 4 of the Honours program, before formally enrolling for the MSc degree. Candidates may be required to write Graduate Record Aptitude and Advanced Chemistry Examinations.

Candidates with an Honours degree, or who have completed a qualifying year, require a minimum of one year of full-time study. The department offers a wide range of courses and research opportunities in analytical, inorganic, organic, physical and theoretical chemistry.

For further information about the MSc program see the Graduate Calendar and the department's Graduate Studies brochure.

Course Descriptions

Note that not all courses are offered in every session. Refer to the applicable term timetable for details.

# Indicates a cross listed course

* Indicates a primary offering of a cross listed course

Prerequisites and Restrictions

Students must check to ensure that prerequisites are met. Students may be deregistered, at the request of the instructor, from any course for which prerequisites and/or restrictions have not been met.

CHEMISTRY COURSES

CHEM 1F92

Chemical Principles and Properties

A chemical approach to describing the natural world. Molecular structure, shapes, and behaviour of molecules emphasizing organic compounds. Bonding and intermolecular interactions; the states of matter; solutions and their properties. Thermochemistry, entropy, free energy, chemical equilibrium, and reaction rates. Labs emphasize chemical syntheses, stoichiometry, and modern analytical techniques.

Lectures, 3 hours per week; tutorial, 1 hour alternating weeks; plus a minimum of six 3-hour labs per term.

Prerequisite(s): a minimum 70 percent grade in 4U/M chemistry (or equivalent course), CHEM 1P00, or permission of the Department.

CHEM 1P00

Introductory Chemistry

Fundamental principles of chemistry. Topics include atomic structure and the periodic table, names and formulas of chemical compounds, principles of chemical bonding, types of chemical reactions, and basic chemical calculations. Tutorials emphasize the development and practice of problem solving skills.

Lectures, 3 hours per week; lab, tutorial and problems solving session, 3 hours per week.

Note: open to students with less than 70 percent 4U/M chemistry or equivalent who are enrolled in a program leading to a BSc degree, or with permission from the Department. CHEM 1P00 is designed to assist those with insufficient background in chemistry to succeed in CHEM 1F92. Students with less than 70 percent in 4U/M chemistry, or who have not taken an advanced high school chemistry course are allowed to take CHEM 1F92 instead of CHEM 1P00 by permission of the Department if they pass a written test of basic chemistry knowledge, to be administered before classes begin.

CHEM 1P90

Chemical Principles and Properties

General chemistry, stoichiometry, inorganic and organic structures and reactions. Laboratory work includes chemical purification and analysis.

Lectures, 3 hours per week; plus a minimum of six 3-hour labs.

Restriction: open to CAST majors or permission of instructor.

CHEM 2P12

Introduction to Modern Physical Chemistry

Phase equilibrium; gas phase kinetics; electronic structure of atoms and molecules; interaction of light with matter.

Lectures, 3 hours per week; tutorial, 2 hours per week; plus a minimum of six 3-hour labs.

Prerequisite(s): CHEM 1F92; one of MATH 1P01 and 1P02, MATH 1P05 and 1P06 (preferred), MATH 1P97.

CHEM 2P20

Principles of Organic Chemistry I

Introduction to the principles and techniques of organic chemistry; correlation of reactions and physical properties of organic compounds with structure and energetic concepts. Introduction to applications of spectroscopy in organic chemistry and biochemistry. Selected experiments in organic preparations and techniques.

Lectures, 3 hours per week; tutorial 1.5 hours per week; lab, 3 hours per week.

Prerequisite(s): CHEM 1F92 (minimum 60 percent) or permission of the instructor.

CHEM 2P21

Principles of Organic Chemistry II

Introduction to aromatic molecules and electrophilic aromatic substitution reactions. Chemistry of natural products, their origin and biological significance. Topics include concepts of carbonyl and carbohydrate chemistry, DNA and an introduction to amino acids and proteins. Selected experiments in organic synthesis, and characterization and analysis.

Lectures, 3 hours per week; tutorial 1.5 hours per week; lab, 3 hours per week.

Prerequisite(s): CHEM 2P20.

CHEM 2P32

Principles of Inorganic Chemistry

A survey of the periodic table stressing periodicity of chemical behaviour. Chemistry and reactions in aqueous solutions; structure and bonding in simple compounds; applications to biological and environmental processes.

Lectures, 3 hours per week; plus a minimum of six 3-hour labs.

Prerequisite(s): CHEM 1F92.

CHEM 2P42

Introduction to Analytical Chemistry

Introduction to separation methods such as chromatography, solvent extraction and precipitation; use of buffers for pH-control; statistical treatment of analytical data including normal distributions, significance testing and linear regression.

Lectures, lab, 6 hours per week.

Prerequisite(s): CHEM 1F92.

*CHEM 2P63

Introduction to Biophysical Chemistry

(also offered as BTEC 2P63)

Physical chemistry as applied to biological sciences. Introductory thermodynamics, kinetics, equilibria, and transport phenomena as applied to proteins, biological membranes and other biological systems. Laboratory work includes kinetic measurements, equilibrium constant measurements and protein purification and characterization.

Lectures, lab, 6 hours per week.

Prerequisite(s): CHEM 1F92; one of MATH 1P01 and 1P02, MATH 1P05 and 1P06 (preferred), MATH 1P97.

CHEM 2P98

Undergraduate Research

Undergraduate research project carried out either in the department under the supervision of a faculty member or as an employee in a chemical industry or other suitable laboratory.

Restriction: open to CHEM (single or combined) majors and permission of the Department.

Note: if both CHEM 2P98 and CHEM 3P98 are taken, only one of these may be based on work done in the department.

CHEM 3P20

Structure and Reactivity of Organic Molecules

Methods for functional group manipulation including oxidation, reduction and the use of protecting groups in organic chemistry. General methods for carbon-carbon bond formation emphasizing three dimensional structure and mechanism. Modern methods of asymmetric synthesis. Selected experiments in synthetic organic chemistry and the handling of air and water sensitive reagents.

Lectures, lab, 6 hours per week.

Prerequisite(s): CHEM 2P21 or permission of the Department.

Note: CHEM 3P40 recommended. May be taken concurrently.

CHEM 3P21

Organic Reactions

The chemistry of amines, heterocyclic and heteroaromatic compounds. Pericyclic reactions and reactive intermediates. Molecular rearrangements, peptide synthesis and protecting groups, design of organic synthesis. Introduction to organic photochemistry and the chemistry of carbenes.

Lectures, lab, 6 hours per week.

Prerequisite(s): CHEM 3P20.

CHEM 3P30

Main Group Inorganic Chemistry

Systematic inorganic and organometallic chemistry of the transition elements, emphasizing structure, bonding and reactivity in inorganic and organometallic compounds. Selected experiments in inorganic and organometallic synthesis; use of modern structural methods for determination of composition, structure and bonding.

Lectures, lab, 6 hours per week.

Prerequisite(s): CHEM 2P32.

Note: CHEM 3P40 recommended. May be taken concurrently.

Completion of this course will replace previous assigned grade and credit obtained in CHEM 3P32.

CHEM 3P31

Transition Metal Chemistry

Continuation of CHEM 3P30, emphasizing the main group elements.

Lectures, lab, 6 hours per week.

Prerequisite(s): CHEM 3P30 (3P32).

Note: CHEM 3P40 recommended. May be taken concurrently.

CHEM 3P40

Spectroscopic Techniques for Structure Elucidation

Use of instrumental methods for the determination of structures of molecules. Techniques will include mass spectrometry, nuclear magnetic resonance spectroscopy, covered Fourier transform infrared spectroscopy, visible and UV spectroscopy, computerized data manipulation.

Lectures, tutorial, 6 hours per week.

Restriction: students must have a minimum of 9.0 overall credits.

Prerequisite(s): CHEM 2P20.

CHEM 3P41

Instrumental Methods for Quantitative Analysis

Use of instrumental methods for quantitative determination of elements and molecular species. Techniques include chromatography, atomic spectrometry, X-ray fluorescence spec-trometry, nuclear emission and neutron-activation analysis, introduction to electroanalytical techniques. Emphasis on sample preparation and cleanup and aspects of quality assurance/quality control.

Lectures, lab, 6 hours per week.

Restriction: students must have a minimum of 9.0 overall credits.

Prerequisite(s): CHEM 2P42.

CHEM 3P51

Quantum Chemistry

Schrodinger equation, solution of the harmonic oscillator problem, hydrogen atom, angular momentum theory, variational method with applications to atomic and molecular systems, molecular orbital theory and simple group theory. Introduction to FORTRAN 77.

Lectures, 3 hours per week; lab, 2 hours per week; tutorial, 1 hour per week.

Prerequisite(s): CHEM 2P12.

CHEM 3P53

Atomic and Molecular Structure and Spectroscopy

Group theory and theory of electro-magnetic radiation and spectroscopic transitions. Rotational and vibrational spectroscopy (Microwave, IR, Raman); atomic and molecular electronic spectroscopy (UV/Visible); magnetic resonance (NMR, EPR); X-ray crystallography.

Lectures, lab, 6 hours per week.

Prerequisite(s): CHEM 3P51.

CHEM 3P60

Industrial Chemistry

Principles and practice of industrial chemistry. Survey of the chemical industry, pollution control, plant design, corrosion and similar topics. Selected industrial processes will be discussed in detail. Tours of chemical plants and industrial laboratories.

Lectures, 3 hours per week; seminars and plant tours, 3 hours per week.

Prerequisite(s): one credit from CHEM 2P12, 2P20, 2P32, 2P42, 2P63.

CHEM 3P61

Organic Chemistry in Industry

Industrial organic chemicals including raw materials, base and commodity chemicals, and chemicals with specialized applications, such as dyes and pigments, fluorophores, agrochemicals, surfactants, and pharmaceuticals.

Lectures, seminar, 3 hours per week.

Prerequisite(s): CHEM 2P20, 2P21 and 2P63.

*CHEM 3P62

Bio-organic Chemistry

(also offered as BTEC 3P62)

Mechanistic description of the biosynthesis and metabolism of natural products including alkaloids, terpenes and acetate-derived compounds. Selected examples of biologically/medicinally active classes of natural products along with their physiological modes of activity.

Lectures, 3 hours per week.

Prerequisite(s): CHEM 2P21.

*CHEM 3P93

Protein and Nucleic Acid Chemistry

(also offered as BTEC 3P93)

Chemistry and structure of nucleic acids, proteins, and carbohydrates. Selected aspects of chemical synthesis and biosynthesis, including mechanisms of protein folding, post-translational modification, targeting, sequencing, detection techniques and biochemical/medical applications of these molecules.

Lectures, lab, 6 hours per week.

Prerequisite(s): CHEM 2P21.

Completion of this course will replace previous assigned grade and credit obtained in CHEM (BTEC) 3P63.

CHEM 3P98

Undergraduate Research Project

Undergraduate research project carried out either in the department under the supervision of a faculty member or as an employee in a chemical industry or other suitable laboratory.

Restriction: open to CHEM (single or combined) majors with 9.0 overall credits and permission of the Department.

Note: if both CHEM 2P98 and CHEM 3P98 are taken, only one of these may be based on work done in the department.

CHEM 4F90

Research Project

Experimental or theoretical research to be carried out under faculty supervision.

Restriction: open to CHEM (single or combined) and BCHM majors with approval to year 4 (honours) and permission of the Chair.

Prerequisite(s): CHEM 3P40 or 3P41.

Corequisite(s): CHEM 4F91.

CHEM 4F91

Thesis

The thesis incorporates the results of the research in CHEM 4F90 and forms the basis for a seminar to be presented by the student.

Restriction: open to CHEM (single or combined) and BCHM majors with approval to year 4 (honours) and permission of the Chair.

Prerequisite(s): CHEM 3P40 or 3P41.

Corequisite(s): CHEM 4F90.

CHEM 4P01

Special Topics

Tutorials, seminars, special projects or directed readings in an area of chemistry.

Lectures/seminar/ tutorial, 3 hours per week.

Restriction: open to CHEM (single or combined) majors with a minimum of 14.0 overall credits and permission of the Chair.

CHEM 4P14

Statistical Thermodynamics in Chemistry and Biology

Ensembles, entropy, free energy, statistical mechanics of simple gases and solids, heat capacity, chemical equilibrium, substrate binding, water as a solvent, and polymers and biopolymers.

Lectures, seminar, 3 hours per week.

Prerequisite(s): CHEM 3P51.

Corequisite(s): CHEM 3P53.

CHEM 4P17

Biophysical Photochemistry

Principles of light induced processes such as electron, energy and signal transfer and their role in biological systems. Marcus theory, Dexter and Foerster mechanisms of energy transfer. The optical and magnetic resonance spectroscopy of excited states.

Lectures, 3 hours per week.

Prerequisite(s): CHEM 3P40, 3P53 or permission of the instructor.

*CHEM 4P18

Computational Chemistry: Applications in Biotechnology

(also offered as BTEC 4P18)

Structure-based drug design, molecular modelling, conformational search techniques, secondary and tertiary protein structure prediction, quantitative structure activity relationships and bioinformatics.

Lectures, 3 hours per week.

Restriction: students must have a minimum of 13.5 overall credits.

Prerequisite(s): CHEM 2P12 or 2P63.

CHEM 4P21

Organic Reactions and Synthesis

The disconnection approach to organic synthesis. Problems of chemo-, regio- and stereo-selectivity. Appreciation of elaborate syntheses. Synthetic organic chemistry topics from the recent literature.

Lectures, seminar, 3 hours per week.

Prerequisite(s): CHEM 3P21.

CHEM 4P22

Organic Reactions and Mechanisms

Topics include conformational analysis, introduction to transition state theory and the description of stereo and electronic control in organic reactions. Pertinent applications will be taken from the recent literature.

Lectures, seminar, 3 hours per week.

Prerequisite(s): CHEM 3P21.

CHEM 4P23

Organometallics in Organic Synthesis

Use of organometallic reagents for organic transformations. Metalation and trans-metalation using organolithium, magnesium, cerium and zinc reagents; stable precursors and reactive intermediates in transition metal catalyzed organic reactions employing palladium, nickel, ruthenium, and other metals. Topics from recent literature involving applications to organic synthesis, emphasizing stereoselectivity.

Lectures, seminar, 3 hours per week.

Prerequisite(s): CHEM 3P21.

*CHEM 4P27

Enzyme and Co-enzyme Mechanisms

(also offered as BTEC 4P27)

Hydrolytic and other processes catalyzed by enzymes lacking non-protein prosthetic groups; transferase reactions involving biotin, pyridoxal phosphate, thiamine pyrophosphate, folic acid and cobalamin; oxidation mechanisms involving pyridine nucleotides, flavoenzymes, hydroperoxidases and oxgenases.

Lectures, seminar, 3 hours per week.

Prerequisite(s): CHEM 2P21, BCHM 3P01and 3P02.

CHEM 4P30

Advanced Co-ordination Chemistry

Bonding and electronic structure of transition metal coordination complexes through an application of symmetry properties and group theory tools. Topics include bonding, electronic structure and properties (ligand field theory), molecular magnetism, EPR properties.

Prerequisite(s): CHEM 2P32 and 3P51.

CHEM 4P31

Advanced Inorganic and Organometallic Chemistry

Continuation of CHEM 3P30 and 3P31 focusing on advanced topics of inorganic and organometallic chemistry of main group and transition metal elements, emphasizing the use of modern physical methods for determination of composition, structure and bonding of inorganic and organometallic compounds.

Lectures, 3 hours per week.

Prerequisite(s): CHEM 3P31 and CHEM 3P53.

Note: CHEM 3P53 may be taken concurrently with permission of the instructor.

CHEM 4P32

Biological Inorganic Chemistry

Overview of biological inorganic chemistry focusing on the uptake, transport and storage of metal ions, electron-transfer systems, hydrolytic enzymes, oxygen transport/activation, nitrogen metabolism and metallotherapeutics.

Lectures, seminar, 3 hours per week.

Restriction: students must have a minimum of 12.0 overall credits.

Prerequisite(s): CHEM 2P21 and 2P32.

CHEM 4P41

Enviro-Analytical Chemistry

Chemical speciation studied by a variety of modern analytical techniques. Transport and fate of various compounds and elements in the environment.

Lectures, seminar, 3 hours per week.

Prerequisite(s): CHEM 3P41.

CHEM 4P60

Principles of Polymer Chemistry

Polymer synthesis involving condensation, living anionic and cationic polymerization and atom transfer radical polymerization. Cross-linked and dendritic polymers and their properties, and the role played by polymers in biomedical applications such as drug delivery and implantable devices.

Lectures, seminar, 3 hours per week.

Prerequisite(s): CHEM 2P20 and 2P21.

Note: CHEM 3P20 and 3P21 are recommended.

CHEM 4P61

Principles of Silicon Chemistry

Chemistry of silicon in organic, organometallic and polymeric compounds emphasizing structure, bonding and reactivity. Applications of silicon in the biomedical field and the interaction with biomolecules.

Lectures, 3 hours per week.

Prerequisite(s): CHEM 2P20 and 2P21.

Note: CHEM 2P32, 3P20 and 3P21 are recommended.

*CHEM 4P67

Biophysical Techniques

(also offered as BCHM 4P67 and BTEC 4P67)

Modern instrumental methods of biotechnology emphasizing understanding theory. Development of newer technologies which utilize biological components. Topics include optical, X-ray and NMR techniques, separation techniques, hybridization assays, immunoassays, biosensors and mass spectral techniques; membrane chemistry.

Lectures, seminar, 3 hours per week.

Prerequisite(s): CHEM 2P21 and 2P63 or permission of the instructor.

CHEM 4P68

Biotransformations

(also offered as BTEC 4P68)

The organic reactions carried out by isolated enzymes, fungal cultures and bacteria. The production of pharmaceutical, agricultural and industrial chemicals by biological processes.

Lectures, 3 hours per week.

Prerequisite(s): one of CHEM 3P20, 3P62, 3P93 (3P63) or permission of the instructor.

CHEM 4P92

Library Research and Seminar

Detailed study of the scientific literature under faculty supervision.

Restriction: open to students in the BSc with Major Chemistry program with a minimum of 15.0 overall credits or permission of the Department.

Note: the results of the study will be written up in a major essay and presented as a formal seminar.

SCIENCE COURSES

SCIE 1P50

Science and Society I

Basic questions and problems in understanding the nature of science in relation to current environmental issues and their impact on society. Most common scientific concepts and theories associated with major environmental problems facing the world today.

Lectures, 3 hours per week; seminar, 1 hour alternate weeks.

Note: for non-science majors. Co-ordinated through the Department of Chemistry.

Completion of this course will replace previously assigned grade and credit obtained in SCIE 1F30.

SCIE 1P51

Science and Society II

Introduction to interrelationships between science, technology and society. Topics include the nature of science and technology, genetic engineering, pharmaceutical industry and food additives.

Lectures, 3 hours per week; seminar, 1 hour alternate weeks.

Note: for non-science majors. Co-ordinated through the Department of Chemistry.

Completion of this course will replace previously assigned grade and credit obtained in SCIE 1F30.

CO-OP COURSES

CHEM 0N01

Work Placement I

First co-op work placement (4 months) with an approved employer.

Restriction: open to CHEM Co-op students.

CHEM 0N02

Work Placement II

Second co-op work placement (4 months) with an approved employer.

Restriction: open to CHEM Co-op students.

CHEM 0N03

Work Placement III

Third co-op work placement (4 months) with an approved employer.

Restriction: open to CHEM Co-op students.

CHEM 0N04

Work Placement IV

Optional Co-op work placement (4 months) with an approved employer.

Restriction: open to CHEM Co-op students.

CHEM 0N05

Work Placement V

Optional Co-op work placement (4 months) with an approved employer.

Restriction: open to CHEM Co-op students.

CHEM 2C01

Co-op Reflective Learning and Integration I

Provide student with the opportunity to apply what they've learned in their academic studies through career-oriented work experiences at employer sites.

Restriction: open to CHEM Co-op students.

Prerequisite(s): SCIE 0N90.

Corequisite(s): CHEM 0N01.

Note: students will be required to prepare learning objectives, participate in a site visit, write a work term report and receive a successful work term performance evaluation.

CHEM 2C02

Co-op Reflective Learning and Integration II

Provide student with the opportunity to apply what they've learned in their academics studies through career-oriented work experiences at employer sites.

Restriction: open to CHEM Co-op students.

Prerequisite(s): SCIE 0N90.

Corequisite(s): CHEM 0N02.

Note: students will be required to prepare learning objectives, participate in a site visit, write a work term report and receive a successful work term performance evaluation.

CHEM 2C03

Co-op Reflective Learning and Integration III

Provide student with the opportunity to apply what they've learned in their academic studies through career-oriented work experiences at employer sites.

Restriction: open to CHEM Co-op students.

Prerequisite(s): SCIE 0N90.

Corequisite(s): CHEM 0N03.

Note: students will be required to prepare learning objectives, participate in a site visit, write a work term report and receive a successful work term performance evaluation.

CHEM 2C04

Co-op Reflective Learning and Integration IV

Provide student with the opportunity to apply what they've learned in their academic studies through career-oriented work experiences at employer sites.

Restriction: open to CHEM Co-op students.

Prerequisite(s): SCIE 0N90.

Corequisite(s): CHEM 0N04.

Note: students will be required to prepare learning objectives, participate in a site visit, write a work term report and receive a successful work term performance evaluation.

CHEM 2C05

Co-op Reflective Learning and Integration V

Provide student with the opportunity to apply what they've learned in their academics studies through career-oriented work experiences at employer sites.

Restriction: open to CHEM Co-op students.

Prerequisite(s): SCIE 0N90.

Corequisite(s): CHEM 0N05.

Note: students will be required to prepare learning objectives, participate in a site visit, write a work term report and receive a successful work term performance evaluation.

SCIE 0N90

Co-op Training and Development

Framework for the development of learning objectives for individual work terms, for students in the co-op programs in the Faculty of Mathematics and Science. Includes orientation to the co-op experience, goal setting, career planning, résumé preparation and interview skills preparation.

Lectures, presentations, site visits, 2 hours per week.

Restriction: open to Science Co-op students.

Note: see Director of Co-op Programs Office.