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PhD Fields of Specialization: Organic ChemistryAnalytical & Inorganic Chemistry Physical and Computational Chemistry Dean Ian D. Brindle Faculty of Mathematics & Science Associate Faculty Dean Greg Finn Faculty of Mathematics & Science |
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Professor Emeritus Jack M. Miller (Chemistry)ProfessorsIan D. Brindle (Chemistry), J. Stephen Hartman (Chemistry),Tomas Hudlicky (Chemistry), Stuart M. Rothstein (Chemistry and physics), Art van der Est (Chemistry) Associate Professors Jeffrey K. Atkinson (Chemistry), Heather Gordon (Chemistry), Georgii Nikonov (Chemistry), Melanie Pilkington (Chemistry)Assistant ProfessorsTravis Dudding (Chemistry), Martin Lemaire (Chemistry), Costa Metallinos (Chemistry), Hongbin (Tony) Yan (Chemistry) Adjunct ProfessorChristopher H. Marvin (National Water Research Institute) Administrative Assistant Chris Skorski 905-688-5550, extension 3406 Mackenzie Chown E206 |
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The department provides facilities for students intending to work towards their master's and/or doctoral degrees in Chemistry. Faculty members specialize in organic/bio-organic chemistry, analytical chemistry, inorganic chemistry, and physical/theoretical chemistry. The department also supports MSc and PhD degrees in Biotechnology. |
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Successful completion of an Honours Bachelor's degree, or equivalent, in Chemistry or a cognate discipline such as biochemistry or biotechnology, with at least an upper B average. All students are required to provide results from a completed Graduate Record Examination (GRE). Agreement from a faculty supervisor to supervise the student is also required for admission to the program.Those lacking sufficient background preparation may be required to complete a qualifying term/year to upgrade their applications. Completion of a qualifying term/year does not guarantee acceptance into the program.The Departmental Graduate Committee will review all applications and recommend for admission a limited number of suitable candidates. Students interested in part-time study at the MSc level should consult the Graduate Program Director. |
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Candidates with an Honours degree or who have completed a qualifying year, require a minimum of one year of full-time study. The program must include CHEM 5F90; two 5(alpha)00 level half credits; one half credit (or one credit) which may be at either the 4(alpha)00 or 5(alpha)00 level; and participation in the Seminar Course CHEM 5P95 in which each student will present one seminar on a topic approved by the candidate's Supervisor and attend all seminars presented in the department. Additional credits may be required of candidates with insufficient preparation in their area of research specialization. As part of CHEM 5F90, every MSc candidate must prepare and defend a thesis that demonstrates a capacity for independent work of acceptable scientific calibre. |
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Successful completion of an MSc in Chemistry, or equivalent, or closely allied discipline eg. Biochemistry, with at least an upper B average. Alternatively, students who have successfully completed one year in the Chemistry MSc program may apply to be transferred to the PhD program. The Departmental Graduate Committee will review all applications and recommend for admission a limited number of suitable candidates. It is not possible to complete a PhD degree entirely on a part-time basis. After completion of the residency requirement (three years) a student may request part-time status, provided that a draft of the thesis has been submitted, but before submission of the final copy and scheduling of the defense has begun. Students with MSc degrees in Chemistry with a background in biological applications of chemistry may apply for admission into Brock's PhD program in Biotechnology. |
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A minimum equivalent of three years (36 months) of resident, full-time study is required. Students registered full-time will be expected to complete all degree requirements within four years. Students proceeding from an honours B.Sc. or equivalent must complete a total of 4.5 credits ( 9 half-credits). In addition to a non-credit scientific writing course, CHEM 5N01, these must include CHEM 7F90; CHEM 5P95 and 7P95; four 5(alpha)00 level half-credits, and one additonal half-credit that may be either at the 4(alpha)00 or 5(alpha)00 level . In any of the fields, one half-credit may be taken from other 5(alpha)00 level courses offered in the graduate programs of Biology, Biotechnology, Computer Science, Mathematics, or Physics with the permission of the Supervisory Committee. Students in the Organic Field must take CHEM 5P19 (Organic Reaction Mechanisms) and one synthesis course ( CHEM 4P21, 5P21, or 5P23. The remaining three half-credit course requirements can be chosen from the remaining synthesis courses and CHEM 5P20, 5P22, 5P24, 5P25, 5P27, 5P28 or 5P40. Students in the Physical and Computational Field must take CHEM 5P00, and four courses from CHEM 4P14, 5P01, 5P03, 5P14, 5P13, 5P19, PHYS 4P52, 5P50, and 5P76.Students in the Inorganic Field must take four courses from 5P31, 5P32, 5P33, 5P41, 5P44, 5P45, 5P67. For students entering with an MSc degree, or equivalent, the PhD program must include CHEM 7F90; CHEM 5P95 and 7P95, CHEM 5N01 and at least three 5(alpha)00 level half-credits. The choice of these and additional credits, required for candidates with insufficient preparation in their areas of research specialization, are at the discretion of the supervisory committee. Continued enrolment in the Doctor of Philosophy program requires the successful completion of a Candidacy Examination at a convenient time before the end of the student's second year in the program. The examining committee will be composed of the student's supervisor, two members of the student's supervisory committee, one additional member from the Department involved in the program and one member from a Department in the Faculty of Mathematics and Science not participating in the program. |
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The following research fields are currently represented, described in detail on our website:http://www.brocku.ca/chemistry/research/interests.html |
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Synthesis of heterocyclic, aromatic and aliphatic systems; enantioselective synthesis and catalysis; new approaches to natural product synthesis; alkaloids; carbohydrates; cycloaddition reactions; chemoenzymatic asymmetric synthesis; biotransformations; chiral synthon production; isotopically labelled compounds; fluorescent molecules and affinity labels, and bioconjugates. |
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Trace and ultra-trace determination of elements in complex matrices. Development of analytical methods for pesticides and their degradation compounds. Development of techniques for the determination of natural products in wines and insects. Gas chromatography/mass spectrometry and inductively coupled plasma/mass spectrometry, applied to environmental problems. Ligand design and crystal engineering aimed at self-assembly of novel molecule-based materials, including incorporation of large macrocycles as building blocks; molecular magnetism studies involving three-dimensional network architectures self-assembled from cyanide ligands and metallic centres; high spin clusters; the influence of paramagnetic transition metal ions such as Cu2+ and VO2+ on the excited state dynamics of porphyrin-based photosynthesis model systems. |
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Statistical mechanical investigations of biologically-relevant molecules via Monte Carlo and molecular dynamics simulations; molecular modelling for structural analysis and applications of pattern recognition to problems of chemical interest (e.g. quantitative-structure activity relationships (QSAR) and comparative molecular field analysis (CoMFA)); solving the Schroedinger Equation by using computer simulation (quantum Monte Carlo) methods; computational tools to explore the structure of proteins; modern time-resolved electron spin resonance (ESR) spectroscopy to study the structure and function of photosynthetic reaction centres and porphyrin-based model systems; theoretical and experimental work on the spin polarization and spin dynamics of coupled triplet-doublet pairs in copper and vanadyl porphyrins; study of reaction mechanisms using theory; rationalization and prediction of stereoselectivity of catalytic asymmetric reactions using computational theory. |
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Mass Spectrometry Facility: (i) Kratos Concept 1S high resolution, double-focusing, magnetic sector mass spectrometer, with a high speed data acquisition system served by a Sun workstation, equipped with dual polarity EI, CI, FAB, Flow-FAB, PB-MS and infusion probes; (ii)Bruker Esquire HCT LC/MS/MS, fitted with electrospray ionization. Sample interface is via an Agilent 1100 HPLC system or syringe pump infusion. The data system runs enhanced Chemstation/Bruker hybrid software; (iii) Bruker Autoflex MALDI/TOF/TOF system for large molecule, peptide and protein work, capable of tandem MS/MS for protein sequencing and identification. using Bruker Compass software on a networked PC platform. (iv) Agilent 5890/5790 GC/MSD, used for routine research work, with a PC running Chemstation controlling data acquisition and processing; (v) Perkin-Elmer TurboMass Gold GC/MS/HS for research work involving normal liquid samples or gas/liquid/solid samples using the headspace interface. The system console is also capable of library searches with a current NIST database.Nuclear Magnetic Resonance Facility: (i) Bruker Avance 600 MHz. FTNMR equipped for triple resonance, with broadband (BBO) and inverse gradient (TXI) probes for liquid samples and a CP/MAS broadband probe for solids (VTN). All probes have VT capability and the broadband liquid probe is equipped with automatic tuning and matching.(ii) Bruker Avance 300 MHz. FTNMR equipped with a broadband gradient VT probe with F-19 capability (BBFO). The probe is equipped with automatic tuning and matching. Both NMR systems run using Bruker XWinNMR on networked PC platforms running Windows XP professional. The department has a number of workstations for offline processing and a site licence for NUTS( R) processing software on PC and Mac platforms. Electron Paramagnetic Resonance Facility: (i) Bruker ElexSys E580 X-band (9 GHz) EPR spectrometer operating in both cw and pulsed modes. The instrument runs using the Bruxer XEPR software package. (ii) Bruker E-siries Q-band (35 GHz) spectrometer for continuous-wave and transient experiments. All three instruments can be operated with a CF950 cryostat for temperature control between 5K and 300K and they are designed with optical excitation capability using a Continuum Surelite pulsed NdYAG Laser. Computing Facilities: The department has a variety of computers and UNIX workstations and access to a several Beowolf clusters for advanced computation, data interpretation, and molecular modeling. The University is a member of Canada's Shared Hierarchical Academic Research Computing Network (SHARCNET). Students and faculty researchers have access to cluster platform systems, housed at Brock and at other SHARCNET academic institutions. These clusters, in aggregate, constitute the most powerful supercomputer in Canada, ranking on the Top500 supercomputers list. Spectroscopy: (i) Thermo-Mattson RS-1 infrared spectrometer, equipped with various sampling accessories including normal transmission mode, ATR and DRIFT units. Software acquisition and processing is handled with a PC running WinFirst software. Basic library search facilities are available; (ii) Bomem MB100 FTIR, controlled by a PC/Grams based data acquisition and processing system; (iii) Thermo-Spectronic(ATI/Unicam) UV4 ultraviolet/visible spectrometer, controlled by a PC running Vision-32 acquisition and processing software; (iii) Photon Technology International Fluorescence Spectrometer, interfaced to a PC for acquisition and processing; (iv) Molecular Devices SpectraMax microplate spectrofluorometer for direct plate scans. A PC controls data collection and processing; (v) ICP/MS spectrometry in the laboratory of Prof. I.D. Brindle.Chromatography: (i) Agilent 6890 research GC system with a Gerstel prep/autosampler, controlled by an extended version of Chemstation running on a PC; (ii) Waters 600 series LC systems running under PC based Millenium software. Polarimeter: Rudolph Autopol III polarimeter for optical rotation measurements. |
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Note: Not all courses are offered in every session. Students must consult with the Graduate Program Director regarding course offerings and course selection and must have their course selections approved by the Graduate Program Director each term. Refer to the Timetable for scheduling information:http://www.brocku.ca/registrar/guides/grad/timetable/terms.php MSc Research and Thesis Theoretical and/or experimental research. An external examiner will participate in the evaluation of the student's performance in this course. Scientific Writing littThe organizational and stylistic skills of writing and referencing a scientific document. Examples from the various literature forms such as primary journals, reviews, reports, and theses, as well as presentations and seminars. Database use and reference citation, and use of figures and graphs to illustrate data. Students are expected to successfully complete the literature review portion of their thesis to pass this course. Quantum Chemistry: Theory (also offered as PHYS 5P00) Self-consistent-field (SCF) method; configuration interaction; basis functions; electron correlation; physical properties of atoms, diatomic and polyatomic moleculewills. Quantum Chemistry: Applications Application of ab initio molecular orbital theories to problems in atomic and molecular structure, to intermolecular forces and to chemical reactivity. Advanced Topics in Photobiology (also offered as BIOL 5P03) A graduate seminar/lecture course covering topics in photobiology. A series of lectures designed to introduce some of the major research areas in photobiology will be followed by student seminars on selective topics (usually two or three papers on one subject). Special Topics in Physical Chemistry Topics may include aspects of chemical dynamics, molecular spectroscopy, statistical mechanics and quantum theory. Biophysical Photochemistry (also offered as BTEC 5P13) The principles of light-induced processes such as electron, energy, and signal transfer and their role in biological systems. Marcus theory, Dexter and Foerster mechanisms of energy transfer. The optical and magnetic resonance spectroscopy of excited states. Computational Chemistry: Applications in Biotechnology (also offered as BTEC 5P14) Structure-based drug design; molecular modelling; conformational search techniques; secondary and tertiary protein structure prediction; quantitative structure-activity relationships; bioinformatics. Organic Reaction Mechanisms The critical study of papers of mechanistic and/or synthetic interest in the recent literature drawing attention to the ways in which mechanisms are established and applied as well as to the mechanisms themselves. Special Topics in Organic Chemistry Topics may include organic photochemistry, biotransformation, free radical chemistry, symmetry and stereochemistry and a further study of mechanistic or synthetic organic chemistry. Advanced Organic Synthesis Strategies in the design of organic syntheses; examples from the current literature will be used to illustrate new trends in synthetic methodology and approaches to the synthesis of complex or organic molecules and natural products; new reagents in organic synthesis including an examination of organometallics and enzymes. Special Topics in Chemical Biology (also offered as BTEC 5P22) Focuses on the chemical-biology of select biologically active compounds of current interest in the literature. The occurrence, biosynthesis and biological activity, including structure-activity correlations, will be studied. Strategies toward the chemical synthesis of these important compounds will also be investigated. Stereoselective Synthesis A survey of the methodology and reagents currently used in stereoselective synthetic organic chemistry. Details concerning methods for achieving absolute and relative stereo-control are discussed, including chiral catalysis and asymmetric induction via substrate- and reagent-based strategies. Applications of the methods to the synthesis of chosen molecules in the literature are provided to illustrate aspects of selectivity. Natural Products Chemistry A study of the structural features, synthesis and biosynthesis of natural products selected from the acetogenin, alkaloid, steroid and terpenoid groups, and other areas. Advanced Enzyme and Co-enzyme Mechanisms (also offered as BTEC 5P27) Hydrolytic and other processes catalyzed by enzymes lacking non-protein prosthetic groups; transferase reactions involving biotin, pyridoxal phosphate, thiamine pyrophosphate, folic acid and cobalamin; oxidation mechanisms involving pyridine nucleotides, flavoenzymes, hydroperoxidases and oxygenases.Prerequisite: CHEM 4P27 or permission of the instructor. Bioorganic Chemistry: Carbohydrates and Nucleic Acids (also offered as BTEC 5P28)Mono- and oligosaccharides; preparative carbohydrate chemistry; neoglycoconjugates; immunochemistry of carbohydrates; nucleosides and nucleotides; oligonucleotide synthesis; medicinal chemistry of oligonucleotides. Special Topics in Inorganic Chemistry A directed reading course in advanced inorganic chemistry based on a critical approach to the original literature. Topics are to be arranged between the student and instructor. Advanced Methods for Materials Characterization The theory and practice of common characterization methods used for the structural elucidation of inorganic compounds. Techniques will include, IR, UV-Vis, EPR, mass spectroscopy, cyclic voltammery, X-ray crystallography, and magnetic measurements. Supramolecular Chemistry An examination of non-covalent interactions and their impact in biology and chemistry. Topics will include self-assembly, molecular recognition, polymer organization, dendrimers, crystallization and applications of the above for the design and synthesis of nanostructured materials. Advanced Spectroscopy The theory and practice of common spectroscopic techniques used for structural identification of chemical compounds and analysis of their properties, emphasizing mainly nuclear magnetic resonance and mass spectrometry. Special Topics in Analytical Chemistry The course will include topics such as pesticide and residue analysis, advanced chromatographic techniques, chemical analysis applied to environmental and agricultural problems, preconcentration techniques and new analytical techniques. Directed Readings in Chemistry An investigation of a specific area or group of related topics in contemporary chemistry. Candidates for graduate degrees may present one such special topic course. Approval of the departmental graduate studies committee is required prior to registration. Atomic Spectrometry Arcs, sparks, ICP, DCP, AA, will be investigated. Evaluation of advantages and disadvantages of excitation sources and sample introduction techniques. Particular concentration in this course will be the sample and how it is analyzed and some discussion will centre on sample preparation, matrix elimination or minimization. Solid sampling methods such as laser ablation and glow discharge will be reviewed. Biophysical Techniques (also offered as BIOL 5P67 and BTEC 5P67) An advanced seminar/lecture course on experimental techniques in biochemistry. The focus is on understanding the theory, applications and limitations of a variety of techniques students will encounter during their graduate studies. Techniques will range from advanced spectroscopy (absorption, fluorescence, NMR, X-ray diffraction) to molecular.Note: course taught in conjunction with BIOL/CHEM/BCHM 4P67. Graduate Seminar Presentation of one full-length (60 min) research seminar in a public forum and attendance at least ten such student seminars (or other seminars designated as appropriate) during the student's graduate program. PhD Research and Thesis Original theoretical and/or experimental research and thesis. Graduate Seminar II Presentation of one full-length (60 min) research seminars in a public forum and attending at least ten such student seminars (or other seminars designated as appropriate) during the student's graduate program. |
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2006-2007 Graduate Calendar
Last updated: November 2, 2006 @ 08:56AM