{"id":91476,"date":"2024-03-13T10:55:10","date_gmt":"2024-03-13T14:55:10","guid":{"rendered":"https:\/\/brocku.ca\/brock-news\/?p=91476"},"modified":"2024-03-19T11:32:00","modified_gmt":"2024-03-19T15:32:00","slug":"nserc-funded-brock-research-using-insect-viruses-to-benefit-human-health","status":"publish","type":"post","link":"https:\/\/brocku.ca\/brock-news\/2024\/03\/nserc-funded-brock-research-using-insect-viruses-to-benefit-human-health\/","title":{"rendered":"NSERC-funded Brock research using insect viruses to benefit human health"},"content":{"rendered":"

The word \u201cvirus\u201d usually evokes a sense of fear or foreboding, a bad thing to be avoided. But for Ian Patterson, a virus can be a lifesaver \u2013 under the right conditions.<\/p>\n

The Assistant Professor of Biological Sciences and his team are investigating how the ribonucleic acid (RNA) in viruses that infect an insect can be manipulated to avoid infection and disease in humans.<\/p>\n

Patterson has partnered with Associate Professor Fass\u00e9li Coulibaly at the Biomedicine Discovery Institute of Monash University in Australia on their project, \u201cCharacterizing an insect-specific virus to deliver RNA to target cells.\u201d<\/p>\n

Their project is supported by $206,450 in funding from the Natural Sciences and Engineering Research Council (NSERC)\u2019s Alliance International Grant<\/a>.<\/p>\n

The grant is part of a funding bundle announced by Minister of Transport Pablo\u00a0Rodriguez Wednesday, March 13 on behalf of Minister of Innovation, Science and Industry Fran\u00e7ois-Philippe Champagne.<\/p>\n

Viruses act like packages containing genetic information. If those viral proteins are deconstructed, the virus\u2019s genetic information can be replaced with molecules that benefit human health. Those beneficial molecules are then protected by the virus shell.<\/p>\n

\"Assistant

Brock Assistant Professor of Biological Sciences Ian Patterson (far right) shows his students various virus samples as part of their research on a project he is co-leading. From left: Ishika Sharma (BSc \u201923), a Biotechnology master\u2019s student; Alec Chunta, an undergraduate student on Match of Minds award; Assmaa El Khal, a Biotechnology master\u2019s student; and Joseph Muthoni, PhD student in Biological Sciences.<\/p><\/div>\n

A protein on the virus enables it to invade a host cell through receptors on the cell membrane\u2019s surface so that the cell receives the virus\u2019s genome and becomes infected.<\/p>\n

\u201cWe need to understand more about these virus proteins and entry mechanisms,\u201d says Patterson. \u201cThe goal of this knowledge is to use the virus structure to package and deliver proteins that prevent or treat disease in humans.\u201d<\/p>\n

Coulibaly\u2019s Australian team will be using state-of-the-art equipment to map out the structure and entry process of the viruses they\u2019re studying and will send this information to Patterson and his lab.<\/p>\n

Patterson is an expert in virus biology and reverse genetic systems<\/a>, which involves deleting and mutating particular genes to understand how genes function within DNA or RNA sequences.<\/p>\n

\u201cI\u2019m going to be manipulating the virus,\u201d says Patterson. \u201cBased on the structure, the Australian team will determine critical parts of the virus proteins, then I will make the mutation in the virus to confirm the function. It\u2019s a complementary process, each of us providing essential tasks that the other person doesn’t do.\u201d<\/p>\n

By learning some of the structural biology techniques through their collaborators, he and his team can begin to use the electron microscope at the Brock-Niagara Validation, Prototyping and Manufacturing Institute<\/a> (VPMI) for the research.<\/p>\n

The long-term vision would be to \u201cessentially use these viruses as sort of a drug delivery tool,\u201d says Patterson.<\/p>\n

He notes that so-called \u201cbeneficial viruses\u201d are already being developed in Canada for certain cancer treatments and medicines.<\/p>\n

\u201cThe results of our research will enhance our understanding of a viral pathway for virus infection and underpin a strategy to engineer the new entry protein,\u201d says Patterson.<\/p>\n

Acting Brock Vice-President, Research Michelle McGinn says she\u2019s excited by the project\u2019s potential.<\/p>\n

\u201cBy connecting with international partners engaged in a complementary line of research and taking advantage of the state-of-the-art equipment located in the Brock\u2013Niagara Validation, Prototyping and Manufacturing Institute, Dr. Patterson and his team are pursuing groundbreaking work that truly matters,\u201d says McGinn. \u201cIt is phenomenal that they have identified an innovative approach to genetically engineer a virus to be beneficial for human health.\u201d<\/p>\n

Vance Badawey, Member of Parliament for Niagara Centre, says the \u201cfunding provided under the Alliance International Grant through the Natural Sciences and Engineering Research Council is essential for students who are looking to study with international partners.\u201d<\/p>\n

\u201cThese investments are important not only for Brock University, but for the Niagara region, as professors like Dr. Patterson continue to do groundbreaking work,\u201d he says.<\/p>\n

\u201cOur government remains committed to funding innovative scientific research to tackle our toughest challenges,\u201d says Chris Bittle, Member of Parliament for St. Catharines.<\/p>\n

\u201cBy investing in research that explores RNA, we can better prepare ourselves against illness and disease,\u201d he says. \u201cIt is exciting to see potentially groundbreaking research projects being undertaken right here in St. Catharines at Brock University.\u201d<\/p>\n

NSERC\u2019s Alliance International Grant<\/a> supports researchers in Canada to work with leading international researchers from the academic sector, and to establish and grow international research collaborations and projects that have a high potential for impact and of global importance and benefit to Canada.<\/p>\n","protected":false},"excerpt":{"rendered":"

The word \u201cvirus\u201d usually evokes a sense of fear or foreboding, a bad thing to be avoided. But for Ian Patterson, a virus can be a lifesaver \u2013 under the right conditions.<\/p>\n","protected":false},"author":20,"featured_media":91477,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7484,7,3319,4052,41,1,5],"tags":[12349,8907,6586,348,13323,13325,13324,11716,4939,13322,2195,1099,6743,11562,12807,11515,8207],"_links":{"self":[{"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/posts\/91476"}],"collection":[{"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/comments?post=91476"}],"version-history":[{"count":4,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/posts\/91476\/revisions"}],"predecessor-version":[{"id":91626,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/posts\/91476\/revisions\/91626"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/media\/91477"}],"wp:attachment":[{"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/media?parent=91476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/categories?post=91476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/tags?post=91476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}