{"id":53936,"date":"2018-10-19T14:05:34","date_gmt":"2018-10-19T18:05:34","guid":{"rendered":"https:\/\/brocku.ca\/brock-news\/?p=53936"},"modified":"2019-04-22T11:37:52","modified_gmt":"2019-04-22T15:37:52","slug":"brock-chemist-sets-up-international-bionanotechnology-collaboration","status":"publish","type":"post","link":"https:\/\/brocku.ca\/brock-news\/2018\/10\/brock-chemist-sets-up-international-bionanotechnology-collaboration\/","title":{"rendered":"Brock chemist sets up international bionanotechnology collaboration"},"content":{"rendered":"<p>Feng Li is casting his nano-net wide.<\/p>\n<p>The Brock University Assistant Professor of Chemistry is laying the groundwork for a partnership with the Shanghai Institute of Applied Physics at the Chinese Academy of Science.<\/p>\n<p>Li was there recently as a participant of the Ontario-China Young Scientist Exchange Program, a provincial government initiative aiming to develop international research and commercialization activities between Ontario and Chinese organizations.<\/p>\n<p>The program is affiliated with the Ontario government\u2019s <a href=\"https:\/\/brocku.ca\/brock-news\/2018\/04\/three-brock-researchers-capture-ontarios-early-researcher-awards\/\" target=\"_blank\" rel=\"noopener\">Early Researcher Award<\/a>, which Li received earlier this year for his research on the use of DNA nanotechnology to detect diseases.<\/p>\n<p>Breakthrough developments through Li\u2019s research include a <a href=\"https:\/\/brocku.ca\/brock-news\/2018\/07\/tiny-robot-could-be-game-changer-in-fight-against-tuberculosis\/\" target=\"_blank\" rel=\"noopener\">microscopic robot<\/a> that has the potential to identify drug resistance to tuberculosis faster than conventional tests, a <a href=\"https:\/\/brocku.ca\/brock-news\/2018\/01\/brock-researchers-create-groundbreaking-dna-reader-for-disease-detection\/\" target=\"_blank\" rel=\"noopener\">paper-based device<\/a> that can reveal the presence of illness from DNA samples, and a <a href=\"https:\/\/brocku.ca\/brock-news\/2016\/03\/brock-team-builds-microscopic-robot-to-detect-cancer-other-diseases-in-blood-samples\/\" target=\"_blank\" rel=\"noopener\">three-dimensional, microscopic nanomachine<\/a> that can detect diseases in a blood sample within 30 minutes.<\/p>\n<p>Li and his team also <a href=\"https:\/\/brocku.ca\/brock-news\/2016\/12\/computers-with-dna-brock-team-working-to-help-make-it-happen\/\" target=\"_blank\" rel=\"noopener\">created a tool<\/a> that can potentially be used in a future computer that will be made out of DNA. Their technique, called allosteric DNA toehold, has been integrated as a key component in one of the world\u2019s most advanced DNA neural networks by <a href=\"http:\/\/www.qianlab.caltech.edu\/\" target=\"_blank\" rel=\"noopener\">the Qian lab<\/a> at the California Institute of Technology.<\/p>\n<p>During his three-week visit to China, Li worked in the laboratory of Professor Chunhai Fan, who has done breakthrough research in the areas of biosensing, biophotonics, and DNA nanotechnology and computation.<\/p>\n<p>\u201cI never knew him before, but I\u2019d been reading a lot of his work, since he\u2019s a very big name in my field,\u201d says Li. \u201cWhen I heard about this exchange program, his name came to my mind. I contacted him to see whether I could have the opportunity to visit his lab for a couple of weeks.\u201d<\/p>\n<p>Li\u2019s initial research proposal centred on how to modify a sophisticated piece of an electrochemical sensor in Fan\u2019s lab to be able to detect proteins, which would assist Li\u2019s disease detection work.<\/p>\n<p>But, once at the lab, Li became fascinated with Fan\u2019s work on \u2018<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/dna-origami\" target=\"_blank\" rel=\"noopener\">DNA origami<\/a>,\u2019 a technique where long strands of DNA are folded into three-dimensional structures with different shapes.<\/p>\n<p>Li learned to create nano-sized tubes that can potentially be injected into the body to enable targeted, efficient delivery of drugs.<\/p>\n<p>As an example of how this would work, Li refers to the problem of chemotherapy killing healthy cells alongside cancerous ones.<\/p>\n<p>\u201cImagine a box that you can load drugs into,\u201d he says. \u201cThose boxes would only open when there\u2019s a cancer cell. Cancer cells have specific cell-surface proteins or lipids. You use these as a key to unlock the three-dimensional structure. Then you will only deliver drugs to cancer cells over the healthy cells.\u201d<\/p>\n<p>Li is also interested in using the DNA origami technique for diagnostic purposes. One example is the DNA Shape ID. Scientists in Fan\u2019s lab created three-dimensional shapes out of DNA strands and paired these shapes with certain illnesses.<\/p>\n<p>\u201cThey can label different diseases with different shapes, like a triangle or a square,\u201d says Li. \u201cThe scientists use them to determine if the DNA bears mutations. It\u2019s very cool how you can use DNA structures for diagnostic purposes.\u201d<\/p>\n<p>Li says he has set up a collaboration with researchers in his lab at Brock, Fan\u2019s lab at the Shanghai Institute of Applied Physics, and researchers at McMaster University.<\/p>\n<p>Calling Li a \u201crising star in DNA nanotechnology,\u201d Fan says he and Li \u201calmost instantly found that we had a lot of mutual interests in research\u201d when they met.<\/p>\n<p>The <a href=\"https:\/\/news.ontario.ca\/medg\/en\/2016\/07\/ontario-partners-with-china-to-support-young-scientists.html\" target=\"_blank\" rel=\"noopener\">Ontario-China Young Scientist Exchange Program<\/a> was set up two years ago to develop long-term research collaborations between Ontario and Chinese institutions and to encourage the development of leadership skills among participants.<\/p>\n<p>Li was among seven researchers province-wide to be accepted to the program this year.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Feng Li is casting his nano-net wide. The Brock University Assistant Professor of Chemistry is laying the groundwork for a partnership with the Shanghai Institute of Applied Physics at the Chinese Academy of Science.<\/p>\n","protected":false},"author":20,"featured_media":53937,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3319,55,41,1,4,5],"tags":[7830,2881,48,7099,7095,6860,7101,7097,348,4243,7100,7096,7098],"_links":{"self":[{"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/posts\/53936"}],"collection":[{"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/comments?post=53936"}],"version-history":[{"count":1,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/posts\/53936\/revisions"}],"predecessor-version":[{"id":53938,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/posts\/53936\/revisions\/53938"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/media\/53937"}],"wp:attachment":[{"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/media?parent=53936"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/categories?post=53936"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/brocku.ca\/brock-news\/wp-json\/wp\/v2\/tags?post=53936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}