• Molecular Mechanisms of Aging: Uncovering how degenerative protein modifications drive aging and chronic diseases.
• Immunotherapy for Age-Linked Diseases: Developing antibody-based therapies for cardiovascular disease, neurodegeneration, and cancer.
• Cancer Immunotherapy: Creating innovative strategies to harness the immune system against cancer.
• Systems Biology Approaches: Leveraging genomics, proteomics, and advanced ‘omics’ technologies to unravel health and disease mechanisms.
• Epidemiological Analysis Using Large Cohorts: Using big-data epidemiology and large-scale cohort datasets (e.g., UK Biobank, Framingham Heart Study, CLSA) to identify new risk factors and disease associations at the population level.

• Canadian Association on Gerontology
• American Heart Association
• International Society of Vascular Behavioural and Cognitive Disorders
• American Society for Biochemistry and Molecular Biology
• American Society for Mass Spectrometry (ASMS)
• American Chemical Society

• Development of therapeutic antibodies for human diseases.
• From target discovery to diagnostics and therapy of disease.

Alaka, A. A., Ngan, S. C., Shookoni M., MacPherson R.E.K., Faught B.E., Klentrou P., Kalaria R., Chen C. P., & Sze, S. K. Enhancing The Validity of CAIDE Dementia Risk Scores with Resting Heart Rate and Machine Learning: An Analysis from National Alzheimer Coordinating Centre Across All Races/Ethnicity. Alzheimers Dement In press (2025).

Patel, R., Kalailingam, P., Ngan, S. C., Iyappan, R., Nwaeze, J., D’Amore, B., Katoueezadeh, M., Thinakaran, Y., Laein, M. H., Faught, B. E., MacPherson, R. E., Tsiani, E. L., Klentrou, P., De Kleijn, D., Kalaria, R. N., McCarthy, N. E. & Sze, S. K. IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier Breakdown. bioRxiv, 2025.2007.2008.663800, doi:10.1101/2025.07.08.663800 (2025).

Kalailingam, P., Ngan, S. C., Gallart-Palau, X., Serra, A., Datta, A., Ch’ng, T. H., Tsiani, E. L., Klentrou, P., Kalaria, R. N., McCarthy, N. E., de Kleijn, D. & Sze, S. K. Anti-isoDGR Antibody Inhibits Atherosclerosis Induced by Western Diet in ApoE^-/- mice. bioRxiv, 2025.2006.2009.658749, doi:10.1101/2025.06.09.658749 (2025).

Fernández-Rhodes, M., Suárez, M., Molet, I., Suárez-García, S., Arola, L., Sze, S. K., Gallart-Palau, X. & Serra, A. Molecular Imprints of Clinical Comorbidities in Hypothalamic Extracellular Vesicles at the Onset of Obesity. ACS Omega 10, 23563-23581, doi:10.1021/acsomega.5c02274 (2025).

Mol, B. M., Motsak, T., Hoekstra, J. K. R., Zuluaga, V. O., Rumpff-Derksen, S., Paspali-Strik, I., Ngan, S. C., Pasterkamp, G., de Borst, G. J., Sze, S. K. & de Kleijn, D. P. V. High Levels of Plasma and Plaque IsoDGR-Modified Fibronectin are Associated with Rupture Prone Plaque Characteristics in Carotid Endarterectomy Patients. Eur J Vasc Endovasc Surg, doi:10.1016/j.ejvs.2025.04.067 (2025).

Kalailingam, P., Ngan, S. C., Iyappan, R., Nehchiri, A., Mohd-Kahliab, K. H., Lee, B. S. T., Sharma, B., Machan, R., Bo, S. T., Chambers, E. S., Fajardo, V. A., Macpherson, R. E. K., Liu, J., Klentrou, P., Tsiani, E. L., Lim, K. L., Su, I. H., Gao, Y. G., Richar, A. M., Kalaria, R. N., Chen, C. P., Balion, C., de Kleijn, D., McCarthy, N. E. & Sze, S. K. Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation. Aging Cell 24, e14425, doi:10.1111/acel.14425 (2025).

He, F., Aebersold, R., Baker, M. S., Bian, X., Bo, X., Chan, D. W., Chang, C., Chen, L., Chen, X., Chen, Y. J., Cheng, H., Collins, B. C., Corrales, F., Cox, J., E, W., Van Eyk, J. E., Fan, J., Faridi, P., Figeys, D., Gao, G. F., Gao, W., Gao, Z. H., Goda, K., Goh, W. W. B., Gu, D., Guo, C., Guo, T., He, Y., Heck, A. J. R., Hermjakob, H., Hunter, T., Iyer, N. G., Jiang, Y., Jimenez, C. R., Joshi, L., Kelleher, N. L., Li, M., Li, Y., Lin, Q., Liu, C. H., Liu, F., Liu, G. H., Liu, Y., Liu, Z., Low, T. Y., Lu, B., Mann, M., Meng, A., Moritz, R. L., Nice, E., Ning, G., Omenn, G. S., Overall, C. M., Palmisano, G., Peng, Y., Pineau, C., Poon, T. C. W., Purcell, A. W., Qiao, J., Reddel, R. R., Robinson, P. J., Roncada, P., Sander, C., Sha, J., Song, E., Srivastava, S., Sun, A., Sze, S. K., Tang, C., Tang, L., Tian, R., Vizcaíno, J. A., Wang, C., Wang, C., Wang, X., Wang, X., Wang, Y., Weiss, T., Wilhelm, M., Winkler, R., Wollscheid, B., Wong, L., Xie, L., Xie, W., Xu, T., Xu, T., Yan, L., Yang, J., Yang, X., Yates, J., Yun, T., Zhai, Q., Zhang, B., Zhang, H., Zhang, L., Zhang, L., Zhang, P., Zhang, Y., Zheng, Y. Z., Zhong, Q. & Zhu, Y. Author Correction: π-HuB: the proteomic navigator of the human body. Nature 637, E22, doi:10.1038/s41586-024-08555-x (2025).

Mohammad, A., Finch, M. S., Rouhana, S., Mashouri, P., Barry, C., Hubbard, E. F., Sze, N., Beaudette, S. M., Pyle, W. G., Power, G. A. & MacPherson, R. E. K. Accelerated ovarian failure results in brain alterations related to Alzheimer’s disease that are not recovered by high-intensity interval training in mice. Alzheimers Dement 21, e14463, doi:10.1002/alz.14463 (2025).

He, F., Aebersold, R., Baker, M. S., Bian, X., Bo, X., Chan, D. W., Chang, C., Chen, L., Chen, X., Chen, Y. J., Cheng, H., Collins, B. C., Corrales, F., Cox, J., E, W., Van Eyk, J. E., Fan, J., Faridi, P., Figeys, D., Gao, G. F., Gao, W., Gao, Z. H., Goda, K., Goh, W. W. B., Gu, D., Guo, C., Guo, T., He, Y., Heck, A. J. R., Hermjakob, H., Hunter, T., Iyer, N. G., Jiang, Y., Jimenez, C. R., Joshi, L., Kelleher, N. L., Li, M., Li, Y., Lin, Q., Liu, C. H., Liu, F., Liu, G. H., Liu, Y., Liu, Z., Low, T. Y., Lu, B., Mann, M., Meng, A., Moritz, R. L., Nice, E., Ning, G., Omenn, G. S., Overall, C. M., Palmisano, G., Peng, Y., Pineau, C., Poon, T. C. W., Purcell, A. W., Qiao, J., Reddel, R. R., Robinson, P. J., Roncada, P., Sander, C., Sha, J., Song, E., Srivastava, S., Sun, A., Sze, S. K., Tang, C., Tang, L., Tian, R., Vizcaíno, J. A., Wang, C., Wang, C., Wang, X., Wang, X., Wang, Y., Weiss, T., Wilhelm, M., Winkler, R., Wollscheid, B., Wong, L., Xie, L., Xie, W., Xu, T., Xu, T., Yan, L., Yang, J., Yang, X., Yates, J., Yun, T., Zhai, Q., Zhang, B., Zhang, H., Zhang, L., Zhang, L., Zhang, P., Zhang, Y., Zheng, Y. Z., Zhong, Q. & Zhu, Y. π-HuB: the proteomic navigator of the human body. Nature 636, 322-331, doi:10.1038/s41586-024-08280-5 (2024).

Vlavcheski, F., MacPherson, R. E. K., Fajardo, V., Sze, N. & Tsiani, E. Carnosic Acid (CA) Induces a Brown Fat-like Phenotype, Increases Mitochondrial Biogenesis, and Activates AMPK in 3T3-L1 Adipocytes. Biomedicines 12, doi:10.3390/biomedicines12071569 (2024).

Ng, Q. Y., Mahendran, V., Lim, Z. Q., Tan, J. H. Y., Wong, J. J. F., Chu, J. J. H., Chow, V. T. K., Sze, N. S. K. & Alonso, S. Enterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis. J Biomed Sci 31, 65, doi:10.1186/s12929-024-01053-2 (2024).

Nadile, M., Sze, N. S. K., Fajardo, V. A. & Tsiani, E. Inhibition of Prostate Cancer Cell Survival and Proliferation by Carnosic Acid Is Associated with Inhibition of Akt and Activation of AMPK Signaling. Nutrients 16, doi:10.3390/nu16091257 (2024).

Choy, D. M. Y., Ang, B. C. H., Adav, S. S., Zheng, Y. B., Goh, C. J. S., Wei, J., Kumaran, A., Chua, C. H., Gan, N. Y., Sze, S. K. & Yip, L. W. L. Aqueous humour protein dysregulation in Asian eyes with primary open angle glaucoma. Exp Eye Res 243, 109887, doi:10.1016/j.exer.2024.109887 (2024).

O’Neill, E. J., Sze, N. S. K., MacPherson, R. E. K. & Tsiani, E. Carnosic Acid against Lung Cancer: Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling. Int J Mol Sci 25, doi:10.3390/ijms25041950 (2024).

Loo, S., Kam, A., Dutta, B., Zhang, X., Feng, N., Sze, S. K., Liu, C. F., Wang, X. & Tam, J. P. Broad-spectrum ginsentides are principal bioactives in unraveling the cure-all effects of ginseng. Acta Pharm Sin B 14, 653-666, doi:10.1016/j.apsb.2023.10.022 (2024).

Nadile, M., Kornel, A., Sze, N. S. K. & Tsiani, E. A Comprehensive Review of Genistein’s Effects in Preclinical Models of Cervical Cancer. Cancers (Basel) 16, doi:10.3390/cancers16010035 (2023).

Tay, A. H. M., Cinotti, R., Sze, N. S. K. & Lundqvist, A. Inhibition of ERO1a and IDO1 improves dendritic cell infiltration into pancreatic ductal adenocarcinoma. Front Immunol 14, 1264012, doi:10.3389/fimmu.2023.1264012 (2023).

Sánchez Milán, J. A., Fernández-Rhodes, M., Guo, X., Mulet, M., Ngan, S. C., Iyappan, R., Katoueezadeh, M., Sze, S. K., Serra, A. & Gallart-Palau, X. Trioxidized cysteine in the aging proteome mimics the structural dynamics and interactome of phosphorylated serine. Aging Cell 23, e14062, doi:10.1111/acel.14062 (2024).

Kalailingam, P., Mohd-Kahliab, K. H., Ngan, S. C., Iyappan, R., Melekh, E., Lu, T., Zien, G. W., Sharma, B., Guo, T., MacNeil, A. J., MacPherson, R. E., Tsiani, E. L., O’Leary, D. D., Lim, K. L., Su, I. H., Gao, Y. G., Richards, A. M., Kalaria, R. N., Chen, C. P., McCarthy, N. E. & Sze, S. K. Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation. EMBO Mol Med 15, e18526, doi:10.15252/emmm.202318526 (2023).

Liu, J., Sze, N. S. K., Narushima, M. & O’Leary, D. Weight Change and Risk of Atherosclerosis Measured by Carotid Intima-Media Thickness (cIMT) from a Prospective Cohort-Analysis of the First-Wave Follow-Up Data of the Canadian Longitudinal Study on Aging (CLSA). J Cardiovasc Dev Dis 10, doi:10.3390/jcdd10100435 (2023).

He, Q., Sze, S. K., Ng, K. S. & Koh, C. G. Paxillin interactome identified by SILAC and label-free approaches coupled to TurboID sheds light on the compositions of focal adhesions in mouse embryonic stem cells. Biochem Biophys Res Commun 680, 73-85, doi:10.1016/j.bbrc.2023.09.017 (2023).

Soon, H. R., Gaunt, J. R., Bansal, V. A., Lenherr, C., Sze, S. K. & Ch’ng, T. H. Seizure enhances SUMOylation and zinc-finger transcriptional repression in neuronal nuclei. iScience 26, 107707, doi:10.1016/j.isci.2023.107707 (2023).

Gallart-Palau, X., Lorca, C., Mulet, M., Sánchez Milán, J. A., Lisa, J., Ngan, S. C., Iyappan, R., Katoueezadeh, M., Serra, A. & Sze, S. K. Differential systemic decellularization in vivo to study molecular changes in each vasculature layer in murine models of disease. STAR Protoc 4, 102524, doi:10.1016/j.xpro.2023.102524 (2023).

Tang, G., Wang, W., Wang, X., Ding, K., Ngan, S. C., Chen, J. Y., Sze, S. K., Gao, L., Yuan, P., Lu, X. & Yao, S. Q. Cell-active, irreversible covalent inhibitors that selectively target the catalytic lysine of EGFR by using fluorosulfate-based SuFEx chemistry. Eur J Med Chem 259, 115671, doi:10.1016/j.ejmech.2023.115671 (2023).

Dutta, B., Loo, S., Kam, A., Sze, S. K. & Tam, J. P. Ginsentide TP1 Protects Hypoxia-Induced Dysfunction and ER Stress-Linked Apoptosis. Cells 12, doi:10.3390/cells12101401 (2023).

Oh, Z. G., Ang, W. S. L., Poh, C. W., Lai, S. K., Sze, S. K., Li, H. Y., Bhushan, S., Wunder, T. & Mueller-Cajar, O. A linker protein from a red-type pyrenoid phase separates with Rubisco via oligomerizing sticker motifs. Proc Natl Acad Sci U S A 120, e2304833120, doi:10.1073/pnas.2304833120 (2023).

Panahi, M., Hase, Y., Gallart-Palau, X., Mitra, S., Watanabe, A., Low, R. C., Yamamoto, Y., Sepulveda-Falla, D., Hainsworth, A. H., Ihara, M., Sze, S. K., Viitanen, M., Behbahani, H. & Kalaria, R. N. ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics. Acta Neuropathol Commun 11, 76, doi:10.1186/s40478-023-01558-1 (2023).

Kornel, A., Nadile, M., Retsidou, M. I., Sakellakis, M., Gioti, K., Beloukas, A., Sze, N. S. K., Klentrou, P. & Tsiani, E. Ursolic Acid against Prostate and Urogenital Cancers: A Review of In Vitro and In Vivo Studies. Int J Mol Sci 24, doi:10.3390/ijms24087414 (2023).

He, F., Tay, A. H. M., Calandigary, A., Malki, E., Suzuki, S., Liu, T., Wang, Q., Fernández-Moro, C., Kaisso, M., Olofsson-Sahl, P., Melssen, M., Sze, S. K., Björnstedt, M., Löhr, M. J., Karlsson, M. C. I., Heuchel, R. & Sarhan, D. FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner. Cancer Res 83, 1628-1645, doi:10.1158/0008-5472.Can-22-2932 (2023).

Vinaiphat, A., Pazhanchamy, K., JebaMercy, G., Ngan, S. C., Leow, M. K., Ho, H. H., Gao, Y. G., Lim, K. L., Richards, A. M., de Kleijn, D. P. V., Chen, C. P., Kalaria, R. N., Liu, J., O’Leary, D. D., McCarthy, N. E. & Sze, S. K. Endothelial Damage Arising From High Salt Hypertension Is Elucidated by Vascular Bed Systematic Profiling. Arterioscler Thromb Vasc Biol 43, 427-442, doi:10.1161/atvbaha.122.318439 (2023).

Thuya, W. L., Kong, L. R., Syn, N. L., Ding, L. W., Cheow, E. S. H., Wong, R. T. X., Wang, T., Goh, R. M. W., Song, H., Jayasinghe, M. K., Le, M. T., Hu, J. C., Yong, W. P., Lee, S. C., Wong, A. L., Sethi, G., Hung, H. T., Ho, P. C., Thiery, J. P., Sze, S. K., Guo, T., Soo, R. A., Yang, H., Lim, Y. C., Wang, L. & Goh, B. C. FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites. Theranostics 13, 621-638, doi:10.7150/thno.72297 (2023).

Viegas, J. O., Azad, G. K., Lv, Y., Fishman, L., Paltiel, T., Pattabiraman, S., Park, J. E., Kaganovich, D., Sze, S. K., Rabani, M., Esteban, M. A. & Meshorer, E. RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2. Dev Cell 57, 2731-2744.e2735, doi:10.1016/j.devcel.2022.11.014 (2022).

Ngan, S. C., McCarthy, N. E. & Sze, S. K. pSILAC-Based Determination of Cellular Protein Sorting into Extracellular Vesicles. Methods Mol Biol 2603, 43-58, doi:10.1007/978-1-0716-2863-8_4 (2023).

Datta, A., Chen, C., Gao, Y. G. & Sze, S. K. Quantitative Proteomics of Medium-Sized Extracellular Vesicle-Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers. Int J Mol Sci 23, doi:10.3390/ijms231911670 (2022).

Vinaiphat, A. & Sze, S. K. Proteomics for comprehensive characterization of extracellular vesicles in neurodegenerative disease. Exp Neurol 355, 114149, doi:10.1016/j.expneurol.2022.114149 (2022).

Iyer, U. B., Park, J. E., Sze, S. K., Bozdech, Z. & Featherstone, M. Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates with Evolutionarily Novel Subunits. ACS Omega 7, 14867-14874, doi:10.1021/acsomega.2c00368 (2022).

Leow, M. K., Rengaraj, A., Narasimhan, K., Verma, S. K., Yaligar, J., Thu, G. L. T., Sun, L., Goh, H. J., Govindharajulu, P., Sadananthan, S. A., Michael, N., Meng, W., Gallart-Palau, X., Sun, L., Karnani, N., Sze, N. S. K. & Velan, S. S. Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L). Biosci Rep 42, doi:10.1042/bsr20212543 (2022).

Hemu, X., Zhang, X., Nguyen, G. K. T., To, J., Serra, A., Loo, S., Sze, S. K., Liu, C. F. & Tam, J. P. Characterization and application of natural and recombinant butelase-1 to improve industrial enzymes by end-to-end circularization. RSC Adv 11, 23105-23112, doi:10.1039/d1ra03763c (2021).

Fazil, M., Prasannan, P., Wong, B. H. S., Kottaiswamy, A., Salim, N., Sze, S. K. & Verma, N. K. GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility. Front Immunol 12, 680071, doi:10.3389/fimmu.2021.680071 (2021).

Fazil, M., Chirumamilla, C. S., Perez-Novo, C., Wong, B. H. S., Kumar, S., Sze, S. K., Vanden Berghe, W. & Verma, N. K. The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling. J Biol Chem 297, 101377, doi:10.1016/j.jbc.2021.101377 (2021).

Liew, H. T., To, J., Zhang, X., Hemu, X., Chan, N. Y., Serra, A., Sze, S. K., Liu, C. F. & Tam, J. P. The legumain McPAL1 from Momordica cochinchinensis is a highly stable Asx-specific splicing enzyme. J Biol Chem 297, 101325, doi:10.1016/j.jbc.2021.101325 (2021).

Gong, C., Krupka, J. A., Gao, J., Grigoropoulos, N. F., Giotopoulos, G., Asby, R., Screen, M., Usheva, Z., Cucco, F., Barrans, S., Painter, D., Zaini, N. B. M., Haupl, B., Bornelöv, S., Ruiz De Los Mozos, I., Meng, W., Zhou, P., Blain, A. E., Forde, S., Matthews, J., Khim Tan, M. G., Burke, G. A. A., Sze, S. K., Beer, P., Burton, C., Campbell, P., Rand, V., Turner, S. D., Ule, J., Roman, E., Tooze, R., Oellerich, T., Huntly, B. J., Turner, M., Du, M. Q., Samarajiwa, S. A. & Hodson, D. J. Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis. Mol Cell 81, 4059-4075.e4011, doi:10.1016/j.molcel.2021.07.041 (2021).

Goh, K. J., Ero, R., Yan, X. F., Park, J. E., Kundukad, B., Zheng, J., Sze, S. K. & Gao, Y. G. Translational GTPase BipA Is Involved in the Maturation of a Large Subunit of Bacterial Ribosome at Suboptimal Temperature. Front Microbiol 12, 686049, doi:10.3389/fmicb.2021.686049 (2021).

Koh, Y. Q., Ng, D. Q., Ng, C. C., Boey, A., Wei, M., Sze, S. K., Ho, H. K., Acharya, M., Limoli, C. L. & Chan, A. Extracellular Vesicle Proteome of Breast Cancer Patients with and Without Cognitive Impairment Following Anthracycline-based Chemotherapy: An Exploratory Study. Biomark Insights 16, 11772719211018204, doi:10.1177/11772719211018204 (2021).

Lim, Z. Q., Ng, Q. Y., Oo, Y., Chu, J. J. H., Ng, S. Y., Sze, S. K. & Alonso, S. Enterovirus-A71 exploits peripherin and Rac1 to invade the central nervous system. EMBO Rep 22, e51777, doi:10.15252/embr.202051777 (2021).

Park, J. E., JebaMercy, G., Pazhanchamy, K., Guo, X., Ngan, S. C., Liou, K. C. K., Lynn, S. E., Ng, S. S., Meng, W., Lim, S. C., Leow, M. K., Richards, A. M., Pennington, D. J., de Kleijn, D. P. V., Sorokin, V., Ho, H. H., McCarthy, N. E. & Sze, S. K. Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Atherosclerosis 324, 58-68, doi:10.1016/j.atherosclerosis.2021.03.020 (2021).

Ngan, J. Y. G., Pasunooti, S., Tse, W., Meng, W., Ngan, S. F. C., Jia, H., Lin, J. Q., Ng, S. W., Jaafa, M. T., Cho, S. L. S., Lim, J., Koh, H. Q. V., Abdul Ghani, N., Pethe, K., Sze, S. K., Lescar, J. & Alonso, S. HflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria. Proc Natl Acad Sci U S A 118, doi:10.1073/pnas.2006717118 (2021).

Vinaiphat, A., Low, J. K., Yeoh, K. W., Chng, W. J. & Sze, S. K. Application of Advanced Mass Spectrometry-Based Proteomics to Study Hypoxia Driven Cancer Progression. Front Oncol 11, 559822, doi:10.3389/fonc.2021.559822 (2021).

Harikumar, A., Lim, P. S. L., Nissim-Rafinia, M., Park, J. E., Sze, S. K. & Meshorer, E. Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and β-Catenin. Stem Cell Reports 15, 1260-1274, doi:10.1016/j.stemcr.2020.11.004 (2020).

Gallart-Palau, X., Serra, A. & Sze, S. K. System-wide molecular dynamics of endothelial dysfunction in Gram-negative sepsis. BMC Biol 18, 175, doi:10.1186/s12915-020-00914-0 (2020).

Pattabiraman, S., Azad, G. K., Amen, T., Brielle, S., Park, J. E., Sze, S. K., Meshorer, E. & Kaganovich, D. Vimentin protects differentiating stem cells from stress. Sci Rep 10, 19525, doi:10.1038/s41598-020-76076-4 (2020).

Ngan, S. F. C. & Sze, S. K. Proteomic Profiling of the Secretome of Trichoderma reesei. Methods Mol Biol 2234, 237-249, doi:10.1007/978-1-0716-1048-0_17 (2021).

Tse, S. W., Tan, C. F., Park, J. E., Gnanasekaran, J., Gupta, N., Low, J. K., Yeoh, K. W., Chng, W. J., Tay, C. Y., McCarthy, N. E., Lim, S. K. & Sze, S. K. Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles. Cancers (Basel) 12, doi:10.3390/cancers12102917 (2020).

Sheriff, O., Yaw, A., Lai, S. K., Loo, H. L., Sze, S. K. & Preiser, P. R. Plasmodium falciparum replication factor C subunit 1 is involved in genotoxic stress response. Cell Microbiol 23, e13277, doi:10.1111/cmi.13277 (2021).

Wong, C. F., Lau, A. M., Harikishore, A., Saw, W. G., Shin, J., Ragunathan, P., Bhushan, S., Ngan, S. C., Sze, S. K., Bates, R. W., Dick, T. & Grüber, G. A systematic assessment of mycobacterial F(1) -ATPase subunit ε’s role in latent ATPase hydrolysis. Febs j 288, 818-836, doi:10.1111/febs.15440 (2021).

Sze, S. K., JebaMercy, G. & Ngan, S. C. Profiling the ‘deamidome’ of complex biosamples using mixed-mode chromatography-coupled tandem mass spectrometry. Methods 200, 31-41, doi:10.1016/j.ymeth.2020.05.005 (2022).

Age-related diseases like cardiovascular disease, dementia, and cancer are major public health challenges, causing suffering, disability, and a significant burden on our healthcare systems. Our lab combines cutting-edge laboratory work (using cell lines and animal models) with big-data epidemiology, analyzing datasets such as the UK Biobank, Framingham Heart Study, and the Canadian Longitudinal Study on Aging.

We welcome applications from highly motivated MSc and PhD students, whether your passion lies in wet-lab research, breaking new ground in immunotherapy, or in computational work analyzing large-scale health data. Skills in Python, R, or biostatistics are especially valued. If you are excited to make a real impact in aging and disease research, contact Dr. Newman Sze at [email protected] to discuss opportunities.

Our lab offers hands-on research experiences in biomedical science, focusing on the molecular mechanisms and immunotherapy of age-related diseases. You’ll have opportunities to learn advanced techniques in genomics, proteomics, and data analysis, and to work on projects that matter for public health.

We are seeking undergraduate students from health sciences, biology, computer science, and engineering with a passion for research and cross-disciplinary collaboration. If you want to build new skills, work with large-scale health data, and contribute to discoveries that can extend human healthspan, reach out to Dr. Newman Sze at [email protected].