Newman Sze, PhD

Professor and Tier1 CIHR Canada Research Chair

Newman Sze

Office: CRN 420
905 688 5550 x6098

The goal of my research program is to answer one of the biggest fundamental questions in life science: What causes human aging? In addition to answering this key question, we also aim to understand why aging is the primary risk factor for human chronic diseases. The degenerative protein modifications (DPMs) occur via spontaneous protein modifications (e.g., oxidation, deamidation, glycation) have long been recognized as important mediators of human aging, but the underlying mechanisms by which they impair tissue and organ function have remained elusive. This is largely due to the current technical challenges of performing systems-wide analysis of progressive molecular damage in complex human bio samples. My laboratory is therefore focused on developing advanced ‘omics approach to elucidating DPM-biology in health and diseasesgenerating DPM-specific mAb to investigating functional consequences of DPMs accumulation in tissues, and targeting DPM to advancing immunotherapy for age-linked diseases. The ultimate aim of our research is to develop novel therapeutic and prophylactic approaches to combat the healthcare burden of age-related chronic diseases affecting the aging global population. 

  • Developing new approaches to elucidating molecular mechanisms of health and disease.
  • Understanding degenerative protein modifications as molecular mediators of biological aging.
  • Advancing immunotherapy for cardiovascular disease by targeting isoDGR-modified proteins.
  • Identifying new drug targets for cancer therapy and tumour prevention.
  • Defining molecular mediators underpinning early asymptomatic neurodegeneration. 
  • American Heart Association
  • International Society of Vascular Behavioural and Cognitive Disorders
  • American Society for Biochemistry and Molecular Biology
  • American Society for Mass Spectrometry (ASMS)
  • American Chemical Society 
  • Development of therapeutic antibodies for human diseases.  
  • From target discovery to diagnostics and therapy of disease. 

I am available to supervise graduate and undergraduate students in research projects of proteomics, age-related chronic diseases, health-span extension, immunotherapy and therapeutic monoclonal antibodies development.

  1. Park, J. E.; JebaMercy, G.; Pazhanchamy, K.; Guo, X.; Ngan, S. C.; Liou, K. C. K.; Lynn, S. E.; Ng, S. S.; Meng, W.; Lim, S. C.; Leow, M. K.; Richards, A. M.; Pennington, D. J.; de Kleijn, D. P. V.; Sorokin, V.; Ho, H. H.; McCarthy, N. E.; Sze, S. K., Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Atherosclerosis 2021, 324, 58-68.4.6 
  2. Gong, C.; Krupka, J. A.; Gao, J.; Grigoropoulos, N. F.; Giotopoulos, G.; Asby, R.; Screen, M.; Usheva, Z.; Cucco, F.; Barrans, S.; Painter, D.; Zaini, N. B. M.; Haupl, B.; Bornelöv, S.; Ruiz De Los Mozos, I.; Meng, W.; Zhou, P.; Blain, A. E.; Forde, S.; Matthews, J.; Khim Tan, M. G.; Burke, G. A. A.; Sze, S. K.; Beer, P.; Burton, C.; Campbell, P.; Rand, V.; Turner, S. D.; Ule, J.; Roman, E.; Tooze, R.; Oellerich, T.; Huntly, B. J.; Turner, M.; Du, M. Q.; Samarajiwa, S. A.; Hodson, D. J., Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis. Mol Cell 2021, 81, (19), 4059-4075.e11.16.83 
  3. Goh, K. J.; Ero, R.; Yan, X. F.; Park, J. E.; Kundukad, B.; Zheng, J.; Sze, S. K.; Gao, Y. G., Translational GTPase BipA Is Involved in the Maturation of a Large Subunit of Bacterial Ribosome at Suboptimal Temperature. Front Microbiol 2021, 12, 686049.4.16 
  4. Koh, Y. Q.; Ng, D. Q.; Ng, C. C.; Boey, A.; Wei, M.; Sze, S. K.; Ho, H. K.; Acharya, M.; Limoli, C. L.; Chan, A., Extracellular Vesicle Proteome of Breast Cancer Patients with and Without Cognitive Impairment Following Anthracycline-based Chemotherapy: An Exploratory Study. Biomark Insights 2021, 16, 11772719211018204 
  5. Lim, Z. Q.; Ng, Q. Y.; Oo, Y.; Chu, J. J. H.; Ng, S. Y.; Sze, S. K.; Alonso, S., Enterovirus-A71 exploits peripherin and Rac1 to invade the central nervous system. EMBO Rep 2021, 22, (6), e51777.9.06 
  6. Ngan, J. Y. G.; Pasunooti, S.; Tse, W.; Meng, W.; Ngan, S. F. C.; Jia, H.; Lin, J. Q.; Ng, S. W.; Jaafa, M. T.; Cho, S. L. S.; Lim, J.; Koh, H. Q. V.; Abdul Ghani, N.; Pethe, K.; Sze, S. K.; Lescar, J.; Alonso, S., HflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria. Proc Natl Acad Sci U S A 2021, 118, (12).10.9 
  7. Vinaiphat, A.; Low, J. K.; Yeoh, K. W.; Chng, W. J.; Sze, S. K., Application of Advanced Mass Spectrometry-Based Proteomics to Study Hypoxia Driven Cancer Progression. Front Oncol 2021, 11, 559822.4.42 
  8. Harikumar, A.; Lim, P. S. L.; Nissim-Rafinia, M.; Park, J. E.; Sze, S. K.; Meshorer, E., Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and β-Catenin. Stem Cell Reports 2020, 15, (6), 1260-1274.7.34 
  9. Gallart-Palau, X.; Serra, A.; Sze, S. K., System-wide molecular dynamics of endothelial dysfunction in Gram-negative sepsis. BMC Biol 2020, 18, (1), 175.7.98 
  10. Pattabiraman, S.; Azad, G. K.; Amen, T.; Brielle, S.; Park, J. E.; Sze, S. K.; Meshorer, E.; Kaganovich, D., Vimentin protects differentiating stem cells from stress. Sci Rep 2020, 10, (1), 19525.5.58 
  11. Ngan, S. F. C.; Sze, S. K., Proteomic Profiling of the Secretome of Trichoderma reesei. Methods Mol Biol 2021, 2234, 237-249 
  12. Tse, S. W.; Tan, C. F.; Park, J. E.; Gnanasekaran, J.; Gupta, N.; Low, J. K.; Yeoh, K. W.; Chng, W. J.; Tay, C. Y.; McCarthy, N. E.; Lim, S. K.; Sze, S. K., Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles. Cancers (Basel) 2020, 12, (10).5.33 
  13. Sheriff, O.; Yaw, A.; Lai, S. K.; Loo, H. L.; Sze, S. K.; Preiser, P. R., Plasmodium falciparum replication factor C subunit 1 is involved in genotoxic stress response. Cell Microbiol 2021, 23, (2), e13277.6.33 
  14. Bu, W.; Levitskaya, Z.; Loh, Z. Y.; Jin, S.; Basu, S.; Ero, R.; Yan, X.; Wang, M.; Ngan, S. F. C.; Sze, S. K.; Tan, S. M.; Gao, Y. G., Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state. PLoS Biol 2020, 18, (7), e3000755.14.67 
  15. Ng, S. S.; Park, J. E.; Meng, W.; Chen, C. P.; Kalaria, R. N.; McCarthy, N. E.; Sze, S. K., Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein Translation. ACS Omega 2020, 5, (23), 13528-13540 
  16. Wong, C. F.; Lau, A. M.; Harikishore, A.; Saw, W. G.; Shin, J.; Ragunathan, P.; Bhushan, S.; Ngan, S. C.; Sze, S. K.; Bates, R. W.; Dick, T.; Grüber, G., A systematic assessment of mycobacterial F(1) -ATPase subunit ε’s role in latent ATPase hydrolysis. Febs j 2021, 288, (3), 818-836.4.53 
  17. Tan, C. F.; Teo, H. S.; Park, J. E.; Dutta, B.; Tse, S. W.; Leow, M. K.; Wahli, W.; Sze, S. K., Exploring Extracellular Vesicles Biogenesis in Hypothalamic Cells through a Heavy Isotope Pulse/Trace Proteomic Approach. Cells 2020, 9, (5).4.83 
  18. Vinaiphat, A.; Sze, S. K., Advances in extracellular vesicles analysis. Adv Clin Chem 2020, 97, 73-116.4.72 
  19. Sze, S. K.; JebaMercy, G.; Ngan, S. C., Profiling the ‘deamidome’ of complex biosamples using mixed-mode chromatography-coupled tandem mass spectrometry. Methods 2020.4.53 
  20. Gallart-Palau, X.; Guo, X.; Serra, A.; Sze, S. K., Alzheimer’s disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. Alzheimers Res Ther 2020, 12, (1), 54.6.15 
  21. Koh, Y. Q.; Tan, C. J.; Toh, Y. L.; Sze, S. K.; Ho, H. K.; Limoli, C. L.; Chan, A., Role of Exosomes in Cancer-Related Cognitive Impairment. Int J Mol Sci 2020, 21, (8).3.69 
  22. Paramasivan, S.; Adav, S. S.; Ngan, S. C.; Dalan, R.; Leow, M. K.; Ho, H. H.; Sze, S. K., Serum albumin cysteine trioxidation is a potential oxidative stress biomarker of type 2 diabetes mellitus. Sci Rep 2020, 10, (1), 6475.5.58 
  23. Adav, S. S.; Sze, S. K., Hypoxia-Induced Degenerative Protein Modifications Associated with Aging and Age-Associated Disorders. Aging Dis 2020, 11, (2), 341-364.5.06 
  24. Guo, X.; Park, J. E.; Gallart-Palau, X.; Sze, S. K., Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain. J Proteome Res 2020, 19, (4), 1706-1717.6.92 
  25. He, Q.; Toh, J. D.; Ero, R.; Qiao, Z.; Kumar, V.; Serra, A.; Tan, J.; Sze, S. K.; Gao, Y. G., The unusual di-domain structure of Dunaliella salina glycerol-3-phosphate dehydrogenase enables direct conversion of dihydroxyacetone phosphate to glycerol. Plant J 2020, 102, (1), 153-164.6.97 
  26. Kam, A.; Loo, S.; Fan, J. S.; Sze, S. K.; Yang, D.; Tam, J. P., Roseltide rT7 is a disulfide-rich, anionic, and cell-penetrating peptide that inhibits proteasomal degradation. J Biol Chem 2019, 294, (51), 19604-19615.7.26 
  27. Gupta, N.; Park, J. E.; Tse, W.; Low, J. K.; Kon, O. L.; McCarthy, N.; Sze, S. K., ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer. Oncotarget 2019, 10, (57), 5970-5982.6.64 
  28. Serra, A.; Gallart-Palau, X.; Koh, W. Y.; Chua, Z. J. Y.; Guo, X.; Chow, C. J. J.; Chen, W. M.; Park, J. E.; Li, T.; Tam, J. P.; Sze, S. K., Prooxidant modifications in the cryptome of beef jerky, the deleterious post-digestion composition of processed meat snacks. Food Res Int 2019, 125, 108569.3.52 
  29. Yang, H.; Cheam, N. M. J.; Cao, H.; Lee, M. K. H.; Sze, S. K.; Tan, N. S.; Tay, C. Y., Materials Stiffness-Dependent Redox Metabolic Reprogramming of Mesenchymal Stem Cells for Secretome-Based Therapeutic Angiogenesis. Adv Healthc Mater 2019, 8, (20), e1900929.5.8 
  30. Kannaian, B.; Sharma, B.; Phillips, M.; Chowdhury, A.; Manimekalai, M. S. S.; Adav, S. S.; Ng, J. T. Y.; Kumar, A.; Lim, S.; Mu, Y.; Sze, S. K.; Grüber, G.; Pervushin, K., Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils. Sci Rep 2019, 9, (1), 12579.5.58 
  31. Dembele, L.; Gupta, D. K.; Dutta, B.; Chua, A. C. Y.; Sze, S. K.; Bifani, P., Quantitative Proteomic Analysis of Simian Primary Hepatocytes Reveals Candidate Molecular Markers for Permissiveness to Relapsing Malaria Plasmodium cynomolgi. Proteomics 2019, 19, (19), e1900021.6.09 
  32. Vinaiphat, A.; Sze, S. K., Clinical implications of extracellular vesicles in neurodegenerative diseases. Expert Rev Mol Diagn 2019, 19, (9), 813-824.4.86 
  33. Sun, L.; Verma, S.; Michael, N.; Chan, S. P.; Yan, J.; Sadananthan, S. A.; Camps, S. G.; Goh, H. J.; Govindharajulu, P.; Totman, J.; Townsend, D.; Goh, J. P.; Sun, L.; Boehm, B. O.; Lim, S. C.; Sze, S. K.; Henry, C. J.; Hu, H. H.; Velan, S. S.; Leow, M. K., Brown Adipose Tissue: Multimodality Evaluation by PET, MRI, Infrared Thermography, and Whole-Body Calorimetry (TACTICAL-II). Obesity (Silver Spring) 2019, 27, (9), 1434-1442.4.39 
  34. Krishna, S.; Yim, D. G.; Lakshmanan, V.; Tirumalai, V.; Koh, J. L.; Park, J. E.; Cheong, J. K.; Low, J. L.; Lim, M. J.; Sze, S. K.; Shivaprasad, P.; Gulyani, A.; Raghavan, S.; Palakodeti, D.; DasGupta, R., Dynamic expression of tRNA-derived small RNAs define cellular states. EMBO Rep 2019, 20, (7), e47789.9.06 
  35. Hemu, X.; El Sahili, A.; Hu, S.; Wong, K.; Chen, Y.; Wong, Y. H.; Zhang, X.; Serra, A.; Goh, B. C.; Darwis, D. A.; Chen, M. W.; Sze, S. K.; Liu, C. F.; Lescar, J.; Tam, J. P., Structural determinants for peptide-bond formation by asparaginyl ligases. Proc Natl Acad Sci U S A 2019, 116, (24), 11737-11746.10.9 
  36. Gallart-Palau, X.; Tan, L. M.; Serra, A.; Gao, Y.; Ho, H. H.; Richards, A. M.; Kandiah, N.; Chen, C. P.; Kalaria, R. N.; Sze, S. K., Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Ageing Res Rev 2019, 53, 100909.9 
  37. Park, J. E.; Tse, S. W.; Xue, G.; Assisi, C.; Maqueda, A. S.; Ramon, G. P. X.; Low, J. K.; Kon, O. L.; Tay, C. Y.; Tam, J. P.; Sze, S. K., Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression. Oncotarget 2019, 10, (22), 2136-2150.6.64 
  38. Dai, L.; Lin, J.; Said, A. B.; Yau, Y. H.; Shochat, S. G.; Ruiz-Carrillo, D.; Sun, K.; Chandrasekaran, R.; Sze, S. K.; Lescar, J.; Cheung, P. C., Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage. Biochem Biophys Res Commun 2019, 513, (3), 714-720.3 
  39. Hase, Y.; Polvikoski, T. M.; Ihara, M.; Hase, M.; Zafar, R.; Stevenson, W.; Allan, L. M.; Ennaceur, A.; Horsburgh, K.; Gallart-Palau, X.; Sze, S. K.; Kalaria, R. N., Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis. Neuropathol Appl Neurobiol 2019, 45, (7), 681-697.6.06 
  40. Park, J. E.; Dutta, B.; Tse, S. W.; Gupta, N.; Tan, C. F.; Low, J. K.; Yeoh, K. W.; Kon, O. L.; Tam, J. P.; Sze, S. K., Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift. Oncogene 2019, 38, (26), 5158-5173.8.56 
  41. Huang, J.; Wong, K. H.; Tay, S. V.; Serra, A.; Sze, S. K.; Tam, J. P., Astratides: Insulin-Modulating, Insecticidal, and Antifungal Cysteine-Rich Peptides from Astragalus membranaceus. J Nat Prod 2019, 82, (2), 194-204.3.95 
  42. Siau, A.; Huang, X.; Loh, H. P.; Zhang, N.; Meng, W.; Sze, S. K.; Renia, L.; Preiser, P., Immunomic Identification of Malaria Antigens Associated With Protection in Mice. Mol Cell Proteomics 2019, 18, (5), 837-853.9.88 
  43. Woo, A. R. E.; Sze, S. K.; Chung, H. H.; Lin, V. C., Delineation of critical amino acids in activation function 1 of progesterone receptor for recruitment of transcription coregulators. Biochim Biophys Acta Gene Regul Mech 2019, 1862, (4), 522-533.6.33 
  44. Adav, S. S.; Park, J. E.; Sze, S. K., Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease. Mol Brain 2019, 12, (1), 8.4.9 
  45. Kam, A.; Loo, S.; Dutta, B.; Sze, S. K.; Tam, J. P., Plant-derived mitochondria-targeting cysteine-rich peptide modulates cellular bioenergetics. J Biol Chem 2019, 294, (11), 4000-4011.7.26 
  46. Sze, S. K., Artificially intelligent proteomics improves cardiovascular risk assessment. EBioMedicine 2019, 40, 23-24.6.18 
  47. Gallart-Palau, X.; Serra, A.; Hase, Y.; Tan, C. F.; Chen, C. P.; Kalaria, R. N.; Sze, S. K., Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer’s disease. Brain Pathol 2019, 29, (5), 593-605.8.65 
  48. Shi, M.; Chen, B.; Mahajan, D.; Boh, B. K.; Zhou, Y.; Dutta, B.; Tie, H. C.; Sze, S. K.; Wu, G.; Lu, L., Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5. Nat Commun 2018, 9, (1), 4987.12.35 
  49. Cao, H.; Lee, M. K. H.; Yang, H.; Sze, S. K.; Tan, N. S.; Tay, C. Y., Mechanoregulation of Cancer-Associated Fibroblast Phenotype in Three-Dimensional Interpenetrating Hydrogel Networks. Langmuir 2019, 35, (23), 7487-7495.4.46 
  50. Hernández-Pérez, J.; Serra, A.; Sze, S. K.; Conway, P. L.; Schlundt, J.; Benavides, J., Identification of Arenin, a Novel Kunitz-Like Polypeptide from the Skin Secretions of Dryophytes arenicolor. Int J Mol Sci 2018, 19, (11).3.69 
  51. Serra, A.; Gallart-Palau, X.; Park, J. E.; Lim, G. G. Y.; Lim, K. L.; Ho, H. H.; Tam, J. P.; Sze, S. K., Vascular Bed Molecular Profiling by Differential Systemic Decellularization In Vivo. Arterioscler Thromb Vasc Biol 2018, 38, (10), 2396-2409.7.43 
  52. Kerk, S. K.; Lai, H. Y.; Sze, S. K.; Ng, K. W.; Schmidtchen, A.; Adav, S. S., Bacteria Display Differential Growth and Adhesion Characteristics on Human Hair Shafts. Front Microbiol 2018, 9, 2145.4.16 
  53. Zhang, J.; Wang, J.; Zhou, Z.; Park, J. E.; Wang, L.; Wu, S.; Sun, X.; Lu, L.; Wang, T.; Lin, Q.; Sze, S. K.; Huang, D.; Shen, H. M., Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors. Autophagy 2018, 14, (6), 1043-1059.12.04 
  54. Lim, C. H.; Adav, S. S.; Sze, S. K.; Choong, Y. K.; Saravanan, R.; Schmidtchen, A., Thrombin and Plasmin Alter the Proteome of Neutrophil Extracellular Traps. Front Immunol 2018, 9, 1554.6.43 
  55. Kumari, G.; Wong, K. H.; Serra, A.; Shin, J.; Yoon, H. S.; Sze, S. K.; Tam, J. P., Molecular diversity and function of jasmintides from Jasminum sambac. BMC Plant Biol 2018, 18, (1), 144.4.35 
  56. Dutta, B.; Park, J. E.; Qing, I. T. Y.; Kon, O. L.; Sze, S. K., Soy-Derived Phytochemical Genistein Modifies Chromatome Topology to Restrict Cancer Cell Proliferation. Proteomics 2018, 18, (16), e1700474.6.09 
  57. Wang, L.; Cho, Y. L.; Tang, Y.; Wang, J.; Park, J. E.; Wu, Y.; Wang, C.; Tong, Y.; Chawla, R.; Zhang, J.; Shi, Y.; Deng, S.; Lu, G.; Wu, Y.; Tan, H. W.; Pawijit, P.; Lim, G. G.; Chan, H. Y.; Zhang, J.; Fang, L.; Yu, H.; Liou, Y. C.; Karthik, M.; Bay, B. H.; Lim, K. L.; Sze, S. K.; Yap, C. T.; Shen, H. M., PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell Res 2018, 28, (8), 787-802.15.61 
  58. Adav, S. S.; Wei, J.; Terence, Y.; Ang, B. C. H.; Yip, L. W. L.; Sze, S. K., Proteomic Analysis of Aqueous Humor from Primary Open Angle Glaucoma Patients on Drug Treatment Revealed Altered Complement Activation Cascade. J Proteome Res 2018, 17, (7), 2499-2510.6.92 
  59. Serra, A.; Gallart-Palau, X.; Dutta, B.; Sze, S. K., Online Removal of Sodium Dodecyl Sulfate via Weak Cation Exchange in Liquid Chromatography-Mass Spectrometry Based Proteomics. J Proteome Res 2018, 17, (7), 2390-2400.6.92 
  60. Wongsurawat, T.; Woo, C. C.; Giannakakis, A.; Lin, X. Y.; Cheow, E. S. H.; Lee, C. N.; Richards, M.; Sze, S. K.; Nookaew, I.; Kuznetsov, V. A.; Sorokin, V., Transcriptome alterations of vascular smooth muscle cells in aortic wall of myocardial infarction patients. Data Brief 2018, 17, 1112-1135 
  61. Ruiz-Carrillo, D.; Lin, J.; El Sahili, A.; Wei, M.; Sze, S. K.; Cheung, P. C. F.; Doerig, C.; Lescar, J., The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition. Sci Rep 2018, 8, (1), 7365.5.58 
  62. Su, W.; Kumar, V.; Ding, Y.; Ero, R.; Serra, A.; Lee, B. S. T.; Wong, A. S. W.; Shi, J.; Sze, S. K.; Yang, L.; Gao, Y. G., Ribosome protection by antibiotic resistance ATP-binding cassette protein. Proc Natl Acad Sci U S A 2018, 115, (20), 5157-5162.10.9 
  63. Subbaiah, R. S.; Kerk, S. K.; Lian, Y.; Lunny, D.; Sze, S. K.; Ng, K. W.; Schmidtchen, A.; Adav, S. S., Identification of Antibacterial Components in Human Hair Shafts. Acta Derm Venereol 2018, 98, (7), 708-710.4.24 
  64. Adav, S. S.; Wei, J.; Qian, J.; Gan, N. Y.; Yip, L. W. L.; Sze, S. K., Aqueous humor protein dysregulation in primary angle-closure glaucoma. Int Ophthalmol 2019, 39, (4), 861-871.1.34 
  65. Hemu, X.; Serra, A.; Darwis, D. A.; Cornvik, T.; Sze, S. K.; Tam, J. P., Peptidomic Identification of Cysteine-Rich Peptides from Plants. Methods Mol Biol 2018, 1719, 379-393 
  66. Wongsurawat, T.; Woo, C. C.; Giannakakis, A.; Lin, X. Y.; Cheow, E. S. H.; Lee, C. N.; Richards, M.; Sze, S. K.; Nookaew, I.; Kuznetsov, V. A.; Sorokin, V., Distinctive molecular signature and activated signaling pathways in aortic smooth muscle cells of patients with myocardial infarction. Atherosclerosis 2018, 271, 237-244.4.6 
  67. Sun, L.; Camps, S. G.; Goh, H. J.; Govindharajulu, P.; Schaefferkoetter, J. D.; Townsend, D. W.; Verma, S. K.; Velan, S. S.; Sun, L.; Sze, S. K.; Lim, S. C.; Boehm, B. O.; Henry, C. J.; Leow, M. K., Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan. Am J Clin Nutr 2018, 107, (1), 62-70.6.93 
  68. Adav, S. S.; Subbaiaih, R. S.; Kerk, S. K.; Lee, A. Y.; Lai, H. Y.; Ng, K. W.; Sze, S. K.; Schmidtchen, A., Studies on the Proteome of Human Hair – Identification of Histones and Deamidated Keratins. Sci Rep 2018, 8, (1), 1599.5.58 
  69. Wang, J. W.; Zhang, Y. N.; Sze, S. K.; van de Weg, S. M.; Vernooij, F.; Schoneveld, A. H.; Tan, S. H.; Versteeg, H. H.; Timmers, L.; Lam, C. S. P.; de Kleijn, D. P. V., Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles. Int J Mol Sci 2017, 19, (1).3.69 
  70. Chu, T. T. T.; Sinha, A.; Malleret, B.; Suwanarusk, R.; Park, J. E.; Naidu, R.; Das, R.; Dutta, B.; Ong, S. T.; Verma, N. K.; Chan, J. K.; Nosten, F.; Rénia, L.; Sze, S. K.; Russell, B.; Chandramohanadas, R., Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol 2018, 180, (1), 118-133.5.81 
  71. Cheow, E. S. H.; Cheng, W. C.; Yap, T.; Dutta, B.; Lee, C. N.; Kleijn, D. P. V.; Sorokin, V.; Sze, S. K., Myocardial Injury Is Distinguished from Stable Angina by a Set of Candidate Plasma Biomarkers Identified Using iTRAQ/MRM-Based Approach. J Proteome Res 2018, 17, (1), 499-515.6.92 
  72. Tan, L. H.; Tan, A. J.; Ng, Y. Y.; Chua, J. J.; Chew, W. S.; Muralidharan, S.; Torta, F.; Dutta, B.; Sze, S. K.; Herr, D. R.; Ong, W. Y., Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination. Mol Neurobiol 2018, 55, (7), 5741-5756.6.19 
  73. Saravanan, R.; Adav, S. S.; Choong, Y. K.; van der Plas, M. J. A.; Petrlova, J.; Kjellström, S.; Sze, S. K.; Schmidtchen, A., Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo. Sci Rep 2017, 7, (1), 13136.5.58 
  74. Edupuganti, R. R.; Harikumar, A.; Aaronson, Y.; Biran, A.; Sailaja, B. S.; Nissim-Rafinia, M.; Azad, G. K.; Cohen, M. A.; Park, J. E.; Shivalila, C. S.; Markoulaki, S.; Sze, S. K.; Jaenisch, R.; Meshorer, E., Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation. Stem Cell Reports 2017, 9, (4), 1291-1303.7.34 
  75. Gallart-Palau, X.; Serra, A.; Lee, B. S. T.; Guo, X.; Sze, S. K., Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer’s disease with cerebrovascular disease. J Neuroinflammation 2017, 14, (1), 175.5.78 
  76. Datta, A.; Chai, Y. L.; Tan, J. M.; Lee, J. H.; Francis, P. T.; Chen, C. P.; Sze, S. K.; Lai, M. K. P., An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias. Mol Brain 2017, 10, (1), 36.4.9 
  77. Dutta, B.; Park, J. E.; Kumar, S.; Hao, P.; Gallart-Palau, X.; Serra, A.; Ren, Y.; Sorokin, V.; Lee, C. N.; Ho, H. H.; de Kleijn, D.; Sze, S. K., Monocyte adhesion to atherosclerotic matrix proteins is enhanced by Asn-Gly-Arg deamidation. Sci Rep 2017, 7, (1), 5765.5.58 
  78. Venkatraman, A.; Dutta, B.; Murugan, E.; Piliang, H.; Lakshminaryanan, R.; Sook Yee, A. C.; Pervushin, K. V.; Sze, S. K.; Mehta, J. S., Proteomic Analysis of Amyloid Corneal Aggregates from TGFBI-H626R Lattice Corneal Dystrophy Patient Implicates Serine-Protease HTRA1 in Mutation-Specific Pathogenesis of TGFBIp. J Proteome Res 2017, 16, (8), 2899-2913.6.92 
  79. Wong, K. H.; Tan, W. L.; Kini, S. G.; Xiao, T.; Serra, A.; Sze, S. K.; Tam, J. P., Vaccatides: Antifungal Glutamine-Rich Hevein-Like Peptides from Vaccaria hispanica. Front Plant Sci 2017, 8, 1100.4.49 
  80. Adav, S. S.; Sze, S. K., Simultaneous Enrichment of Plasma Extracellular Vesicles and Glycoproteome for Studying Disease Biomarkers. Methods Mol Biol 2017, 1619, 193-201 
  81. Zhu, Y.; Serra, A.; Guo, T.; Park, J. E.; Zhong, Q.; Sze, S. K., Application of Nanosecond Laser Photolysis Protein Footprinting to Study EGFR Activation by EGF in Cells. J Proteome Res 2017, 16, (6), 2282-2293.6.92 
  82. Gallart-Palau, X.; Serra, A.; Sze, S. K., LERLIC-MS/MS for In-depth Characterization and Quantification of Glutamine and Asparagine Deamidation in Shotgun Proteomics. J Vis Exp 2017, (122).1.33 
  83. Aniweh, Y.; Gao, X.; Hao, P.; Meng, W.; Lai, S. K.; Gunalan, K.; Chu, T. T.; Sinha, A.; Lescar, J.; Chandramohanadas, R.; Li, H. Y.; Sze, S. K.; Preiser, P. R., P. falciparum RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC. Cell Microbiol 2017, 19, (9).6.33 
  84. Park, J. E.; Sun, Y.; Lim, S. K.; Tam, J. P.; Dekker, M.; Chen, H.; Sze, S. K., Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers. Sci Rep 2017, 7, 40569.5.58 
  85. Zhang, S.; Weng, T.; Cheruba, E.; Guo, T.; Chan, H.; Sze, S. K.; Koh, C. G., Phosphatase POPX2 Exhibits Dual Regulatory Functions in Cancer Metastasis. J Proteome Res 2017, 16, (2), 698-711.6.92 
  86. Jin, S.; Sun, J.; Wunder, T.; Tang, D.; Cousins, A. B.; Sze, S. K.; Mueller-Cajar, O.; Gao, Y. G., Structural insights into the LCIB protein family reveals a new group of β-carbonic anhydrases. Proc Natl Acad Sci U S A 2016, 113, (51), 14716-14721.10.9 
  87. Siau, A.; Huang, X.; Weng, M.; Sze, S. K.; Preiser, P. R., Corrigendum: Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. Sci Rep 2016, 6, 37202.5.58 
  88. Wong, K. H.; Tan, W. L.; Serra, A.; Xiao, T.; Sze, S. K.; Yang, D.; Tam, J. P., Ginkgotides: Proline-Rich Hevein-Like Peptides from Gymnosperm Ginkgo biloba. Front Plant Sci 2016, 7, 1639.4.49 
  89. Adav, S. S.; Sze, S. K., Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling. Mol Brain 2016, 9, (1), 92.4.9 
  90. Serra, A.; Gallart-Palau, X.; Wei, J.; Sze, S. K., Characterization of Glutamine Deamidation by Long-Length Electrostatic Repulsion-Hydrophilic Interaction Chromatography-Tandem Mass Spectrometry (LERLIC-MS/MS) in Shotgun Proteomics. Anal Chem 2016, 88, (21), 10573-10582.6.32 
  91. Ren, Y.; Yeoh, K. W.; Hao, P.; Kon, O. L.; Sze, S. K., Irradiation of Epithelial Carcinoma Cells Upregulates Calcium-Binding Proteins That Promote Survival under Hypoxic Conditions. J Proteome Res 2016, 15, (12), 4258-4264.6.92 
  92. Hao, P.; Adav, S. S.; Gallart-Palau, X.; Sze, S. K., Recent advances in mass spectrometric analysis of protein deamidation. Mass Spectrom Rev 2017, 36, (6), 677-692