Jens R. Coorssen, PhD

Professor, Health Sciences (primary) and Biology

Jens R. Coorssen, BSc (Hon), MSc, PhD
Professor, Faculty of Applied Health Sciences cross appointed to the Faculty of Mathematics and Science

Office: Cairns 506
905 688 5550 x6870
jcoorssen@brocku.ca

Jens trained in Canada (BSc and MSc at Brock; PhD at McMaster), the Max Planck Institute for Medical Research (Heidelberg) and the National Institutes of Health (USA). As an Associate Professor, Faculty of Medicine and Hotchkiss Brain Institute, U. Calgary, he was recruited to the new School of Medicine, U. Western Sydney as Foundation Professor & Chair of Molecular Physiology, and established the UWS Molecular Medicine Research Group. He came ‘home’ to Brock in 2016. His quantitative, transdisciplinary research focuses on understanding molecular mechanisms.

  • Proteomics
  • Lipidomics
  • Biomarkers
  • Molecular Mechanisms
  • Preterm Labour
  • Aging
  • Neurodegeneration
  • Healthspan/Lifespan
  • Adjunct Professor, School of Medicine, Western Sydney University
  • Adjunct Professor, Faculty of Medicine, University of Calgary
  • Honorary Professor, School of Medicine, University of Sydney
  • Associate Member, ICORD/Blusson Spinal Cord Centre

Carbonara, K., and Coorssen, J.R. (2020) A ‘green’ approach to fixing polyacrylamide gels: improvement of top-down proteomic analyses. Analytical Biochemistry (Epub 17/7/2020).

Almuslehi, M.S., Sen, M.K., Shortland, P.J., Mahns, D.A., and Coorssen, J.R. (2020) CD8 T-cell recruitment into the central nervous system of cuprizone-fed mice: Relevance to modelling the aetiology of Multiple Sclerosis. Frontiers in Cellular Neuroscience 14:43; doi: 10.3389/fncel.2020.00043. A top-ranked article during first quarter after publication.

D’Silva, A.M., Hyett, J.A., and Coorssen, J.R. (2020) Initial validation testing of four potential early serum biomarkers of preterm labour. Fetal Diagnosis and Therapy 47:497-506.

Sen, M.K., Almuslehi, M.S., Mahns, D.A., Coorssen, J.R., and Shortland, P.J. (2020) Behavioural and histological changes in cuprizone-fed mice. Brain, Behavior, and Immunity 87: 508-523.

Coorssen, J.R., and Padula, M.P. (2020) Top-down Proteomics: In Memory of Dr. Alfred Yergey. Alfred Linwood Yergey, III, 17 September 1941–27 May 2018. Proteomes 8: 1; doi:10.3390/proteomes8010001. Editorial for Special Issue.

Coish, J.M., Crozier, R.W.E., Schieffelin, J.S., Coorssen, J.R., Hunter, F.F., and MacNeil, A.J. (2020) Zika virus replication in a pre-basophilic/mast cell model is augmented by Dengue virus 6 antibody-dependent enhancement and features selective CCL5 secretion. Submitted (J. Virology).

Rituper, B., Guček, A., Lisjak, M., Gorska, U., Šakanović, A., Bobnar, S.T., Lasič, E., Božić, M., Abbineni, P.S., Yilmaz, G., Jorgačevski, J., Kreft, M., Verkhratsky, A., Platt, F.M., Anderluh G, Stenovec, M., Bozič, B., Coorssen, J.R., Zorec, R. (2020) Redistribution of cholesterol from vesicle to plasmalemma controls fusion pore geometry. Submitted (J. Cell Biol.). BioRxiv preprint (6/04/2020.

Sen, M.K., Almuslehi, M.S., Shortland, P.J., Coorssen, J.R., and Mahns, D.A. (2020) Revisiting the Pathoaetiology of Multiple Sclerosis: Has the Tail been Wagging the Mouse? Submitted (Annals of Neurology).

Shanu, A., Ng, N., Lauto, A., Coorssen, J.R., and Myers, S.J. (2020) Calcium mediated calpain activation and microtubule dissociation in Hereditary Sensory Neuropathy Type-1 expressing V144D SPTLC1 mutation. Submitted (Neuroscience).

Zhan, X., Li, B., Zhan, X., Schlüter, H., Jungblut, P.R., and Coorssen, J.R. (2019) Innovating the concept and practice of two-dimensional gel electrophoresis in the analysis of proteomes at the proteoform level. Proteomes 7, 36; doi:10.3390/proteomes7040036.

Sen, M.K., Almuslehi, M.S., Gyengesi, E., Myers, S.J., Mahns, D.A., Shortland, P.J. and Coorssen, J.R. (2019) Suppression of the peripheral immune system limits the central immune response following cuprizone-feeding: Relevance to modelling multiple sclerosis. Cells, 8(11), 1314; doi:10.3390/cells8111314 (Special Issue: “Cellular and Molecular Mechanisms in Pathogenesis of Multiple Sclerosis”).

Furber, K.L., Backlund, P.S., Yergey, A.L., and Coorssen, J.R. (2019) Unbiased thiol labeling and Top-Down Proteomic analyses implicate multiple proteins in the late steps of regulated secretion. Proteomes 7(4), 34; https://doi.org/10.3390/proteomes7040034.

Sen, M., Mahns, D., Coorssen, J.R., and Shortland, P. (2019) Behavioural phenotypes in the Cuprizone model of central nervous system demyelination. Neuroscience & Biobehavioral Reviews 107, 23-46.

Dabral, D. and Coorssen, J.R. (2019) Arachidonic acid and lysophosphatidylcholine inhibit multiple late steps of regulated exocytosis. Biochem. Biophys. Res. Comm. 515, 261-267.

Mazinani, S.A., Noaman, N., Pergande, M., Cologna, S.M., Coorssen, J.R.*, and Yan. H.* (2019) Exposure to microwave irradiation at constant culture temperature slows the growth of Escherichia coli DE3 cells, leading to modified proteomic profiles. RSC Advances 9, 11810-11817. *Co-corresponding authors.

Kurgan, N., Noaman, N., Pergande, M.R, Cologna, S.M., Coorssen, J.R.*, and Klentrou, N.* (2019) Changes to the Human Serum Proteome in Response to High Intensity Interval Exercise: A Sequential Top-Down Proteomic Analysis. Frontiers in Physiology, Vol. 10, paper 362. *Co-corresponding authors.

Dabral, D. and Coorssen, J.R. (2019) Combined Omic and functional assays identify Phospholipases A2 that regulate docking/priming in Calcium-triggered exocytosis. Cells 8, 303.

Abbineni, P.S. and Coorssen, J.R. (2018) Sphingolipids modulate docking, Ca2+ sensitivity and membrane fusion of native secretory vesicles. Int. J. Biochem. Cell Biology 104, 43-54.

Noaman, N. and Coorssen, J.R. (2018) Coomassie does it (better): a Robin Hood approach to total protein quantification. Analytical Biochemistry 556, 53-56.

D’Silva, A.M., Hyett, J.A., and Coorssen, J.R. (2018) Proteomic analysis of first trimester maternal serum to identify candidate biomarkers potentially predictive of spontaneous preterm birth. J. Proteomics 178, 31-42.

Mansour, V.J., and Coorssen, J.R. (2018) Quantitative gel electrophoresis. In: Proteomics in Domestic Animals: from Farm to Systems Biology (de Almeida et al., Eds). Springer. ISBN 978-3-319-69681-2.

Noaman, N., Abbineni, P.S., Withers, M., and Coorssen, J.R. (2017) Coomassie staining provides routine (sub)femtomole in-gel detection of intact proteoforms: expanding opportunities for genuine Top-down Proteomics. Electrophoresis 38, 3086–3099.

Abbineni, P.S. and Coorssen, J.R. (2017) Application of High-Throughput Assays to Examine Phospho-Modulation of the Late Steps of Regulated Exocytosis. High Throughput 13; 6(4).

Coorssen, J. and Yergey, A. (2017) Approaches to Top-Down Proteomics: In Honour of Prof. Patrick H. O’Farrell. Proteomes 5, 18. Editorial for Special Issue.

D’Silva, A.M., Hyett, J.A., and Coorssen, J.R. (2017) A routine ‘Top-Down’ approach to analysis of the human serum proteome. Proteomes 5, 13. doi: 10.3390/proteomes5020013.

Shanu, A., Stimpson, S.E., Coorssen, J.R.*, and Myers, S.J.* (2017) Autophagy is up regulated in a neuronal model of Charcot-Marie Tooth Disease that overexpresses Dynamin 2 mutant. Int. J. Neurosci. Res. 1:3. *Co-corresponding authors.

Ormerod, K.G.*, LePine, O.K., Abbineni, P.S., Bridgeman, J.M., Coorssen, J.R.*, Mercier, A.J., and Tattersall, G.J.* (2017) Drosophila development, physiology, behaviour, and lifespan are influenced by altered dietary composition. Fly 11, 153-170. *Co-corresponding authors

Dabral, D., and Coorssen, J.R. (2017) Phospholipase A2: Potential roles in native membrane fusion. Int. J. Biochem. Cell Biol. 85, 1-5.

Stroud, L.J., Slapeta, J., Padula, M.P., Druery, D., Tsiotsioris, G., Coorssen, J.R.*, and Stack, C.M.* (2017) Comparative proteomic analysis of two pathogenic Tritrichomonas foetus genotypes: there is more to the proteome than meets the eye. Int. J. Parasitology 47, 203-213. *Co-corresponding authors.

Coorssen, J.R. (2017) Proteomics. In: Reference Module in Life Sciences. Elsevier Inc. ISBN 9780128096338, http://dx.doi.org/[Pii].

Epstein, J.A., Blank, P.S., Searle, B.C., Catlin, A.D., Cologna, S.M., Olson, M.T., Backlund, P.S., Coorssen, J.R., and Yergey A.L. (2016) ProteinProcessor: A Probabilistic Analysis Using Mass Accuracy and the MS Spectrum. Proteomics 16, 2480-2490.

Stimpson, S.E., Lauto, A., Coorssen, J.R.*, and Myers, S.J.* (2016) Isolation and identification of ER associated proteins with unique expression changes specific to the V144D SPTLC1 mutations in HSN-I. Biochem. Analytical Biochem. 5(1), 248. *Co-corresponding authors.

Partridge, M.A., Gopinath, S., Myers, S.J., and Coorssen, J.R. (2016) An initial top-down proteomic analysis of the standard cuprizone mouse model of Multiple Sclerosis. J. Chem. Biol. 9, 9-18.

Mansour (née Gauci), V.J., Noaman, N., and Coorssen, J.R. (2016) Gel staining techniques – dyeing to know it all. In: eLS (Encyclopedia of Life Sciences). John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0002686.pub3.

Coorssen, J.R. and Yergey, A.L. (2015) Proteomics is analytical chemistry: Fitness-for-purpose in top-down and bottom-up analyses. Proteomes 3, 440-453.

Rogasevskaia, T. and Coorssen, J.R. (2015) The role of phospholipase D in regulated exocytosis. J. Biol. Chem. 290, 28683–28696. Highlighted in the Lipid Chronicles (1/12/2015).

Partridge, M.A., Myers, S.J., Gopinath, S., and Coorssen, J.R. (2015) Proteomics of a conundrum: thoughts on addressing the aetiology vs. progression of Multiple Sclerosis. Proteomics Clinical Applications 9, 838-843. Requested Viewpoint.

Mahadeo, M., Furber, K.L., Lam, S., Coorssen, J.R.*, and Prenner, E.J.* (2015) Secretory vesicle cholesterol: correlating lipid domain organization and Ca2+ triggered fusion. BBA (Biomembranes) 1848, 1165-1174. *Co-corresponding authors.

Stimpson, S.E., Coorssen, J.R.*, and Myers, S.J.* (2015) Optimal isolation of mitochondria for proteomic analyses. Analytical Biochem. 475, 1-3 (Epub 14/01/2015). *Co-corresponding authors.

Stimpson, S.E., Coorssen, J.R.*, and Myers, S.J.* (2015) Mitochondrial protein alterations in a familial peripheral neuropathy caused by the V144D amino acid mutation in the sphingolipid protein, SPTLC1. J. Chem. Biol. 8, 25-35. *Co-corresponding authors.

2019-present: Senior Research Fellow, Faculty of Applied Health Sciences, Brock U.

2016: Paul Harris Fellow of Rotary International; recognition for commitment to Rotary values in supporting community-driven research into Multiple Sclerosis.

2016-present: Adjunct Professor; School of Medicine, Western Sydney University.

2014-present: Honorary Professor; School of Medicine, University of Sydney.

2012: Alumnus of Distinction Award, Brock University.

2009-2016: Head, Molecular Medicine Research Group, Western Sydney University.

2008-2016: Foundation Professor & Chair, School of Medicine, Western Sydney University.

2008: Celebrating Excellence Award, University of Calgary; recognition for “inspiration, innovation, and outstanding contributions to teaching & research”.

2006-2011 Senior Scholar, Alberta Heritage Foundation for Medical Research.

2006-2011 New Investigator, Canadian Institutes of Health Research.

2001-2002 Young Innovator Award, Vice-President (Research), University of Calgary.

2000-2005 Research Scholar, Heart & Stroke Foundation of Canada.

2000-2006 Research Scholar, Alberta Heritage Foundation for Medical Research.

1999-2001 Visiting Professor (Exchange Scientist), Laboratory of Cellular and Molecular Biophysics, NICHD, National Institutes of Health, Bethesda, Maryland, U.S.A.

  • Continuous peer reviewed funding (mostly as PI): agencies, industry and public/private foundations (5 countries); ~$11.3 M in research and infrastructure funding.
  • Panel member / Peer reviewer for (inter)national agencies. Serve on 4 Editorial Boards.
  • Career Totals: 96 Papers, 10 Book Chapters, 141 Abstracts, 49 media highlights, and 185 invited talks internationally.
  • h index 35, g index 60, citations 3811 (Harzing’s); Research Gate Score: 38.73; 8.5K reads.
  • Organizer, Chair and/or Committee member for numerous international conferences.