Jens R. Coorssen, PhD

Professor, Health Sciences (primary) and Biology

Jens R. Coorssen, BSc (Hon), MSc, PhD
Professor, Faculty of Applied Health Sciences cross appointed to the Faculty of Mathematics and Science

Office: Cairns 506
905 688 5550 x6870
jcoorssen@brocku.ca

Jens trained in Canada (BSc and MSc at Brock; PhD at McMaster), the Max Planck Institute for Medical Research (Heidelberg) and the National Institutes of Health (USA). As an Associate Professor, Faculty of Medicine and Hotchkiss Brain Institute, U. Calgary, he was recruited to the new School of Medicine, U. Western Sydney as Foundation Professor & Chair of Molecular Physiology, and established the UWS Molecular Medicine Research Group. He came ‘home’ to Brock in 2016. His quantitative, transdisciplinary research focuses on understanding molecular mechanisms.

  • Proteomics
  • Lipidomics
  • Biomarkers
  • Molecular Mechanisms
  • Adjunct Professor, School of Medicine, Western Sydney University
  • Adjunct Professor, Faculty of Medicine, University of Calgary
  • Honorary Professor, School of Medicine, University of Sydney
  • Associate Member, ICORD/Blusson Spinal Cord Centre

Coorssen, J.R. (2017) Proteomics. In: Reference Module in Life Sciences. Elsevier Inc. ISBN 9780128096338, http://dx.doi.org/[Pii].

Ormerod, K.G.*, LePine, O.K., Abbineni, P.S., Bridgeman, J.M., Coorssen, J.R.*, Mercier, A.J., and Tattersall, G.J. (2017) Drosophila development, physiology, behaviour, and lifespan are influenced by altered dietary composition. Fly (Epub 9/03/2017).

Dabral, D., and Coorssen, J.R. (2017) Phospholipase A2: Potential roles in native membrane fusion. Int. J. Biochem. Cell Biol. 85, 1-5.

Stroud, L.J., Slapeta, J., Padula, M.P., Druery, D., Tsiotsioris, G., Coorssen, J.R.*, and Stack, C.M.* (2017) Comparative proteomic analysis of two pathogenic Tritrichomonas foetus genotypes:  there is more to the proteome than meets the eye. Int. J. Parasitology 47, 203-213.

Mansour (née Gauci), V.J., Noaman, N., and Coorssen, J.R. (2016) Gel staining techniques – dyeing to know it all. In: eLS (Encyclopedia of Life Sciences). John Wiley & Sons, Ltd: Chichester.                                          DOI: 10.1002/9780470015902.a0002686.pub3

Stimpson, S.E., Shanu, A., Coorssen, J.R.*, and Myers, S.J.* (2016) Identifying uniqueprotein alterations caused by SPTLC1 mutations in a transfected neuronal cell model. WorldJ. Neurosci. Vol.6, No. 4. DOI: 10.4236/wjns.2016.64035.

Epstein, J.A., Blank, P.S., Searle, B.C., Catlin, A.D., Cologna, S.M., Olson, M.T., Backlund, P.S., Coorssen, J.R., and Yergey A.L. (2016) ProteinProcessor: A Probabilistic Analysis Using Mass Accuracy and the MS Spectrum. Proteomics 16, 2480-2490.

Stimpson, S.E., Lauto, A., Coorssen, J.R.*, and Myers, S.J.* (2016) Isolation and identification of ER associated proteins with unique expression changes specific to the V144D SPTLC1 mutations in HSN-I. Biochem. Analytical Biochem. 5(1), 248. doi:10.4172/2161-1009.1000248.

Partridge, M.A., Gopinath, S., Myers, S.J., and Coorssen, J.R. (2016) An initial top-down proteomic analysis of the standard cuprizone mouse model of Multiple Sclerosis. J. Chem. Biol.  9, 9-18.

Stimpson, S.E., Coorssen, J.R.*, and Myers, S.J.* (2015) Proteome alterations associated with the V144D SPTLC1 mutation that causes Hereditary Sensory Neuropathy-1. Electronic J. Biol. 11, 176-186.

Coorssen, J.R. and Yergey, A.L. (2015) Proteomics is analytical chemistry: Fitness-for-purpose in top-down and bottom-up analyses. Proteomes 3, 440-453. doi:10.3390/proteomes3040440.

Rogasevskaia, T. and Coorssen, J.R. (2015) The role of phospholipase D in regulated exocytosis. J. Biol. Chem. 290, 28683–28696.

Partridge, M.A., Myers, S.J., Gopinath, S., and Coorssen, J.R. (2015) Proteomics of a conundrum: thoughts on addressing the aetiology vs. progression of Multiple Sclerosis. Proteomics Clinical Applications 9, 838-843.

Mahadeo, M., Furber, K.L., Lam, S., Coorssen, J.R.*, and Prenner, E.J.* (2015) Secretory vesicle cholesterol: correlating lipid domain organization and Ca2+ triggered fusion. BBA (Biomembranes) 1848, 1165-1174.

Stimpson, S.E., Coorssen, J.R.*, and Myers, S.J.* (2015) Optimal isolation of mitochondria for proteomic analyses. Analytical Biochem. 475, 1-3.

Stimpson, S.E., Coorssen, J.R.*, and Myers, S.J.* (2015) Mitochondrial protein alterations in a familial peripheral neuropathy caused by the V144D amino acid mutation in the sphingolipid protein, SPTLC1. J. Chem. Biol. 8, 25-35.

Abbineni, P., Wright, E.P., Rogasevskaia, T.P., Killingsworth, M., Malladi, C., and Coorssen, J.R. (2014) The Sea Urchin Egg and Cortical Vesicles as Model Systems to Dissect the Fast, Ca2+-Triggered Steps of Regulated Exocytosis. In: Neuromethods (Thorn, P., Ed). Humana Press / Springer.

Wright, E., Padula, M., Higgins, V., Aldrich-Wright, J., and Coorssen, J.R. (2014) A Systems Biology approach to understanding the mechanisms of action of an alternative anticancer compound in comparison to cisplatin. Proteomes 2, 501-526.

Oliveira, B.M., Coorssen, J.R.*, and Martins-de-Souza, D. (2014) 2DE: The Phoenix of Proteomics. J. Proteomics 104, 140-150.

Marshall, L.L., Stimpson, S.E., Hyland, R., Coorssen, J.R.*, and Myers, S.J.* (2014) Increased lipid droplet accumulation associated with a peripheral sensory neuropathy. J. Chem. Biol. 7, 67-76.

Wright, E.P., Partridge, M.A., Padula, M.P., Gauci, V.J., Malladi, C.S., and Coorssen, J.R. (2014) Top-down proteomics: Enhancing 2D gel-electrophoresis from tissue processing to high sensitivity protein detection. Proteomics 14, 872-889.

Wright, E.P., Prasad, K.A.G., Padula, M.P., and Coorssen, J.R. (2014) Deep Imaging: How much of the Proteome Does Current Top-Down Technology Already Resolve? PLoS ONE 9(1): e86058. doi:10.1371/journal.pone.008605

Coorssen, J.R. (2013) Top-down Proteomics: 2D gels are an integral part of the process. In: Farm Animal Proteomics 2013, pp. 31-33 (de Almeida, A. et al., Eds). Wageningen Academic Publishers / Springer. ISBN 978-90-8686-776-9.

Coorssen, J.R. (2013) Proteomics. In: Brenner’s Encyclopedia of Genetics, 2nd Edition, Part 1231 (Maloy, S.; Hughes, K., Editors-in-Chief.). Academic Press / Elsevier.

Butt, R.H., and Coorssen, J.R. (2013) Coomassie Blue as a near-IR flourescent stain: a systematic comparison with Sypro Ruby for in-gel protein detection. Mol. Cell. Proteomics 12, 3834-3850.

Abbineni, P.S., Hibbert, J.E., and Coorssen, J.R. (2013) Critical role of cortical vesicles in dissecting regulated exocytosis: Overview of insights into fundamental molecular mechanisms. The Biological Bulletin 224, 200-217.

Rituper, B., Chowdhury, H.H., Jorgacevski, J., Coorssen, J.R., Kreft, M., and Zorec, R. (2013) Cholesterol-mediated membrane surface area dynamics in neuroendocrinecells. Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids 1831, 1228-1238.

Gauci, V.J., Padula, M.P., and Coorssen, J.R. (2013) Coomassie blue staining for high sensitivity gel-based proteomics. Journal of Proteomics 90, 96-106.

  • Continuous peer reviewed funding (mostly as PI): agencies, industry and public/private foundations (5 countries); ~$10.6 M in research and infrastructure funding.
  • Panel member / Peer reviewer for (inter)national agencies. Serve on 6 Editorial Boards.
  • Career Totals: 71 Papers, 9 Book Chapters, 116 Abstracts, 45 media highlights, and 180 invited talks internationally.
  • h index 32, g index 52 (Harzing’s)
  • Research Gate Score: 37.12; 3K reads, 2.5K citations, 7.9K Reach Score.
  • Organizer, Chair and/or Committee member for numerous international conferences.