Evangelia Litsa Tsiani, PhD

Professor, Health Sciences

Evengelia Litsa Tsiani, PhD

Office: STH 311
905 688 5550 x3881

My research focus is understanding the intracellular signaling pathways that are activated and control muscle glucose transport, metabolism and the defects contributing to insulin resistance/diabetes. An additional research focus is understanding cancer biology and the defects leading to enhanced cell proliferation. My goal/aim is to find food components, nutraceuticals, or functional foods that could modulate certain signaling pathways and be used against insulin resistance /diabetes and cancer.

  • Cell signaling
  • Insulin resistance
  • Muscle metabolism
  • Cell signaling pathways in cancer
  • Investigation of the biological effects of food components
  • Canadian Society for Exercise Physiology (CSEP)
  • Hellenic Canadian Academic Association of Ontario (HCAAO)
  • Brock University Academic Safety Committee
  • HLSC Departmental Hiring Committee
  • HLSC Departmental Curriculum Committee

Shamshoum H, Vlavcheski F, Tsiani E. Anticancer effects of oleuropein. Biofactors. 2017 Jun 14. doi: 10.1002/biof.1366. [Epub ahead of print] Review.

Kurgan N, Tsakiridis E, Kouvelioti R, Moore J, Klentrou P, Tsiani E. Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2. Cancers (Basel). 2017 May 8;9(5). pii: E46. doi: 10.3390/cancers9050046.

Yousef M, Tsiani E. Metformin in Lung Cancer: Review of in Vitro and in Vivo Animal Studies. Cancers (Basel). 2017 May 6;9(5). pii: E45. doi: 10.3390/cancers9050045. Review.

Naimi M, Vlavcheski F, Murphy B, Hudlicky T, Tsiani E. Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation. Clin Exp Pharmacol Physiol. 2017 Jan;44(1):94-102. doi: 10.1111/1440-1681.12674.

Jessy Moore, Michael Yousef, Evangelia Tsiani. Anticancer Effects of Rosemary (Rosmarinus Officinalis L.) Extract and Rosemary Extract Polyphenols. Nutrients. 2016 Nov 17;8(11). pii: E731.

Moore J, Megaly M, MacNeil AJ, Klentrou P, Tsiani E. Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells. Biomed Pharmacother. 2016 Jul 28;83:725-732. doi: 10.1016/j.biopha.2016.07.043. [Epub ahead of print]

Barron CC, Bilan PJ, Tsakiridis T, Tsiani E. Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment. Metabolism. 2016 Feb;65(2):124-39. doi: 10.1016/j.metabol.2015.10.007. Epub 2015 Nov 13. Review.

Pereira S, Yu W Q, Moore J, Mori Y, Tsiani E, and Giacca A. Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo. Nutrition & Diabetes, 2016 May 2;6:e210. doi: 10.1038/nutd.2016.11.

Pereira S, Park E, Moore J, Faubert B, Breen D, Oprescu A, Nahle A, Kwan D, Giacca A, Tsiani E. Resveratrol Prevents Insulin Resistance Caused by Short-Term Elevation of Free Fatty Acids In Vivo. Appl Physiol Nutr Metab. 2015 Published on the web 10 July 2015, 10.1139/apnm-2015-0075

Moore J, Pickering G, Gaudette NJ, Tsiani E. Resveratrol-fortification of red wine does not provide greater inhibition of human lung cancer cell survival compared to non-fortified wine. Journal of Molecular Biochemistry, Vol 4, No 3 (2015)

Naimi M, Tsakiridis T, Stamatatos TC, Alexandropoulos DI, Tsiani E. Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation.Appl Physiol Nutr Metab. 2015 Apr;40(4):407-13.

Mezil YA, Allison D, Kish K, Ditor D, Ward WE, Tsiani E, Klentrou P. Response of Bone Turnover Markers and Cytokines to High-Intensity Low-Impact Exercise.Med Sci Sports Exerc. 2015 Jul;47(7):1495-502.

Barron CC, Moore J, Tsakiridis T, Pickering G, Tsiani E. Inhibition of human lung cancer cell proliferation and survival by wine. Cancer Cell Int. 2014 Jan 23;14(1):6. doi: 10.1186/1475-2867-14-6.PMID:24456610

Storozhuk Y, Hopmans SN, Sanli T, Barron C, Tsiani E, Cutz JC, Pond G, Wright J, Singh G, Tsakiridis T. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer. 2013 Apr 30. doi: 10.1038/bjc.2013.187.

  • Principles of Human Physiology
  • Human Endocrinology
  • Cell Signaling Pathways in Health and Disease (graduate studies)