Professor, Health Sciences
My research focus is understanding the intracellular signaling pathways that are activated and control muscle glucose transport, metabolism and the defects contributing to insulin resistance/diabetes. An additional research focus is understanding cancer biology and the defects leading to enhanced cell proliferation. My goal/aim is to find food components, nutraceuticals, or functional foods that could modulate certain signaling pathways and be used against insulin resistance /diabetes and cancer.
- Cell signaling
- Insulin resistance
- Muscle metabolism
- Cell signaling pathways in cancer
- Investigation of the biological effects of food components
- Canadian Society for Exercise Physiology (CSEP)
- Hellenic Canadian Academic Association of Ontario (HCAAO)
- Brock University Academic Safety Committee
- HLSC Departmental Hiring Committee
- HLSC Departmental Curriculum Committee
Shamshoum H, Vlavcheski F, Tsiani E. Anticancer effects of oleuropein. Biofactors. 2017 Jun 14. doi: 10.1002/biof.1366. [Epub ahead of print] Review.
Kurgan N, Tsakiridis E, Kouvelioti R, Moore J, Klentrou P, Tsiani E. Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2. Cancers (Basel). 2017 May 8;9(5). pii: E46. doi: 10.3390/cancers9050046.
Yousef M, Tsiani E. Metformin in Lung Cancer: Review of in Vitro and in Vivo Animal Studies. Cancers (Basel). 2017 May 6;9(5). pii: E45. doi: 10.3390/cancers9050045. Review.
Naimi M, Vlavcheski F, Murphy B, Hudlicky T, Tsiani E. Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation. Clin Exp Pharmacol Physiol. 2017 Jan;44(1):94-102. doi: 10.1111/1440-1681.12674.
Jessy Moore, Michael Yousef, Evangelia Tsiani. Anticancer Effects of Rosemary (Rosmarinus Officinalis L.) Extract and Rosemary Extract Polyphenols. Nutrients. 2016 Nov 17;8(11). pii: E731.
Moore J, Megaly M, MacNeil AJ, Klentrou P, Tsiani E. Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells. Biomed Pharmacother. 2016 Jul 28;83:725-732. doi: 10.1016/j.biopha.2016.07.043. [Epub ahead of print]
Barron CC, Bilan PJ, Tsakiridis T, Tsiani E. Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment. Metabolism. 2016 Feb;65(2):124-39. doi: 10.1016/j.metabol.2015.10.007. Epub 2015 Nov 13. Review.
Pereira S, Yu W Q, Moore J, Mori Y, Tsiani E, and Giacca A. Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo. Nutrition & Diabetes, 2016 May 2;6:e210. doi: 10.1038/nutd.2016.11.
Pereira S, Park E, Moore J, Faubert B, Breen D, Oprescu A, Nahle A, Kwan D, Giacca A, Tsiani E. Resveratrol Prevents Insulin Resistance Caused by Short-Term Elevation of Free Fatty Acids In Vivo. Appl Physiol Nutr Metab. 2015 Published on the web 10 July 2015, 10.1139/apnm-2015-0075
Moore J, Pickering G, Gaudette NJ, Tsiani E. Resveratrol-fortification of red wine does not provide greater inhibition of human lung cancer cell survival compared to non-fortified wine. Journal of Molecular Biochemistry, Vol 4, No 3 (2015)
Naimi M, Tsakiridis T, Stamatatos TC, Alexandropoulos DI, Tsiani E. Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation.Appl Physiol Nutr Metab. 2015 Apr;40(4):407-13.
Mezil YA, Allison D, Kish K, Ditor D, Ward WE, Tsiani E, Klentrou P. Response of Bone Turnover Markers and Cytokines to High-Intensity Low-Impact Exercise.Med Sci Sports Exerc. 2015 Jul;47(7):1495-502.
Barron CC, Moore J, Tsakiridis T, Pickering G, Tsiani E. Inhibition of human lung cancer cell proliferation and survival by wine. Cancer Cell Int. 2014 Jan 23;14(1):6. doi: 10.1186/1475-2867-14-6.PMID:24456610
Storozhuk Y, Hopmans SN, Sanli T, Barron C, Tsiani E, Cutz JC, Pond G, Wright J, Singh G, Tsakiridis T. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer. 2013 Apr 30. doi: 10.1038/bjc.2013.187.
- Principles of Human Physiology
- Human Endocrinology
- Cell Signaling Pathways in Health and Disease (graduate studies)