Adam J. MacNeil, PhD

Assistant Professor, Health Sciences

Office: STH 304, CA 418 (Lab)
905 688 5550 x6294
amacneil@brocku.ca

Breathe easier! Dr. MacNeil’s research team is investigating novel approaches toward understanding and blocking allergic inflammation caused by chronicpathologies, including asthma, hives, rhinitis, and food allergies. Dr. MacNeil’s Inflammation & Immunity Lab, located in the Cairns Complex, employs innovative biomedical methods and technologies permitting studies from the whole organism-level down to the fundamental genetic, molecular, and cellular building blocks directing uncontrolled inflammatory responses to allergens. Dr. MacNeil believes basic science discoveries feed clinical and translational approaches to a healthier future.

  • Identification of novel targets and innovative therapies in allergic inflammation.
  • Epigenetic control of mast cell differentiation from stem cells.
  • Cell signaling mechanisms in innate immune cell development and activation.
  • Interdisciplinary collaborations exploring the role of immunity in the nervous and cardiovascular systems with links to biological and social outcomes
  • Member of the Canadian Society for Immunology (CSI)
  • Member of the International Union of Immunological Societies (IUIS)
  • Member of the Society for Leukocyte Biology (SLB)
  • Affiliate Member of the Beatrice Hunter Cancer Research Institute(BHCRI)

Moore, J., Megaly, M., MacNeil, A.J., Klentrou, P., and E. Tsiani. 2016. Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells. Biomedicine & Pharmacotherapy306-307: 9-16.

Yang, T., Xie, Z., Li, H., MacNeil, A.J., Tremblay, M., Tang, J.T., and T.J. Lin. 2016. Protein tyrosine phosphatase 1B (PTP1B) suppresses IgE-mediated signal transducer and activator of transcription 5 (STAT5) phosphorylation in mast cells, but is dispensable for IgE-mediated cutaneous reaction in vivo. Cellular Immunology: S0008-8749(16): 30035-1.

Tompkins, N.*, MacNeil, A.J.*, and B. Pohajdak. 2014. Cytohesin-associated scaffolding protein (CASP) is a substrate for granzyme B and ubiquitination.Biochemical and Biophysical Research Communications 452(3): 473-478. * equal contribution

MacNeil, A.J., Jiao, S-C., McEachern, L.A., Yang, Y.J., Dennis A., Yu, H., Xu, Z., Marshall J.S., and T.J. Lin. 2014. MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer. Cancer Research 74(1): 162-72.

MacNeil, A.J., Junkins, R.D., Wu, Z., and T.J. Lin. 2014. Stem cell factor induces AP-1-dependent mast cell IL-6 production via MAPK kinase 3 activity. Journal of Leukocyte Biology 95(6): 903-915.

Wu, Z., Li, Y., MacNeil, A.J., Junkins, R.D., Berman, J.N., and T.J. Lin. 2013. Calcineurin-

Rcan1 interaction contributes to stem cell factor-mediated mast cell activation. Journal of Immunology 191(12): 5885-94.

Junkins R.D., MacNeil, A.J., Wu Z., McCormick C., and T.J. Lin. 2013. Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. Journal of Immunology 190(10): 5178-5186.

Wu Z., MacNeil, A.J., Berman J.N., and T.J. Lin. 2013. Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation. PLoS One 8(3): e58560.

Wu, Z., MacNeil, A.J.*, Junkins, R., Li B., Berman J.N., and T.J. Lin*. 2013. Mast cell FcεRI-induced early growth-response 2 regulates CCL1-dependent CD4+ T cell migration. Journal of Immunology 190(9): 4500-4507. * co-corresponding author

MacNeil, A.J., Yang Y.J., and T.J. Lin. 2011. MAPK kinase 3 specifically regulates FcεRI-mediated IL-4 production by mast cells. Journal of Immunology 187(6): 3374-3382.

Yang Y.J., MacNeil, A.J., Junkins R., Carrigan S.O., Tang J.T., Forward N., Hoskin D., Berman J.N., and T.J. Lin. 2011. Regulator of calcineurin 1 (Rcan1) is required for the development of pulmonary eosinophilia in allergic inflammation in mice. The American Journal of Pathology179(3): 1199-1210.

  • Human Immunology (with experiential wet lab component)
  • Medical Immunology (with experiential wet lab component)
  • Topics in Infection and Immunity
  • Infection Control (online)