Associate Professor, Health Sciences
Breathe easier! Dr. MacNeil’s research team is investigating novel approaches toward understanding and blocking allergic inflammation caused by chronicpathologies, including asthma, hives, rhinitis, and food allergies. Dr. MacNeil’s Inflammation & Immunity Lab, located in the Cairns Complex, employs innovative biomedical methods and technologies permitting studies from the whole organism-level down to the fundamental genetic, molecular, and cellular building blocks directing uncontrolled inflammatory responses to allergens. Dr. MacNeil believes basic science discoveries feed clinical and translational approaches to a healthier future.
- Identification of novel targets and innovative therapies in allergic inflammation.
- Epigenetic control of mast cell differentiation from stem cells.
- Cell signaling mechanisms in innate immune cell development and activation.
- Interdisciplinary collaborations exploring the role of immunity in the nervous and cardiovascular systems with links to biological and social outcomes
- Member of the Canadian Society for Immunology (CSI)
- Member of the International Union of Immunological Societies (IUIS)
- Member of the Society for Leukocyte Biology (SLB)
- Affiliate Member of the Beatrice Hunter Cancer Research Institute(BHCRI)
Moore, J., Megaly, M., MacNeil, A.J., Klentrou, P., and E. Tsiani. 2016. Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells. Biomedicine & Pharmacotherapy306-307: 9-16.
Yang, T., Xie, Z., Li, H., MacNeil, A.J., Tremblay, M., Tang, J.T., and T.J. Lin. 2016. Protein tyrosine phosphatase 1B (PTP1B) suppresses IgE-mediated signal transducer and activator of transcription 5 (STAT5) phosphorylation in mast cells, but is dispensable for IgE-mediated cutaneous reaction in vivo. Cellular Immunology: S0008-8749(16): 30035-1.
Tompkins, N.*, MacNeil, A.J.*, and B. Pohajdak. 2014. Cytohesin-associated scaffolding protein (CASP) is a substrate for granzyme B and ubiquitination.Biochemical and Biophysical Research Communications 452(3): 473-478. * equal contribution
MacNeil, A.J., Jiao, S-C., McEachern, L.A., Yang, Y.J., Dennis A., Yu, H., Xu, Z., Marshall J.S., and T.J. Lin. 2014. MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer. Cancer Research 74(1): 162-72.
MacNeil, A.J., Junkins, R.D., Wu, Z., and T.J. Lin. 2014. Stem cell factor induces AP-1-dependent mast cell IL-6 production via MAPK kinase 3 activity. Journal of Leukocyte Biology 95(6): 903-915.
Wu, Z., Li, Y., MacNeil, A.J., Junkins, R.D., Berman, J.N., and T.J. Lin. 2013. Calcineurin-
Rcan1 interaction contributes to stem cell factor-mediated mast cell activation. Journal of Immunology 191(12): 5885-94.
Junkins R.D., MacNeil, A.J., Wu Z., McCormick C., and T.J. Lin. 2013. Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. Journal of Immunology 190(10): 5178-5186.
Wu Z., MacNeil, A.J., Berman J.N., and T.J. Lin. 2013. Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation. PLoS One 8(3): e58560.
Wu, Z., MacNeil, A.J.*, Junkins, R., Li B., Berman J.N., and T.J. Lin*. 2013. Mast cell FcεRI-induced early growth-response 2 regulates CCL1-dependent CD4+ T cell migration. Journal of Immunology 190(9): 4500-4507. * co-corresponding author
MacNeil, A.J., Yang Y.J., and T.J. Lin. 2011. MAPK kinase 3 specifically regulates FcεRI-mediated IL-4 production by mast cells. Journal of Immunology 187(6): 3374-3382.
Yang Y.J., MacNeil, A.J., Junkins R., Carrigan S.O., Tang J.T., Forward N., Hoskin D., Berman J.N., and T.J. Lin. 2011. Regulator of calcineurin 1 (Rcan1) is required for the development of pulmonary eosinophilia in allergic inflammation in mice. The American Journal of Pathology179(3): 1199-1210.
- Human Immunology (with experiential wet lab component)
- Medical Immunology (with experiential wet lab component)
- Topics in Infection and Immunity
- Infection Control (online)