Member Researchers

Vincenzo De Luca, PhD

Email: vdeluca@brocku.ca
Tel: +1-905-688-5550 ext. 4554

Our research programme is aimed at genomic, proteomic and metabolic approaches to study the biosynthesis of plant natural products and their regulation.

Implicit in these efforts are techniques such as the metabolic pathway engineering of specialized cell factories for the commercial production of valuable natural products in plant cell cultures or in transgenic plants.

Charles Després, PhD

Email: cdespres@brocku.ca
Tel: +1-905-688-5550 ext. 3100

One powerful mechanism used by plants to ward off pathogens is called “induced resistance” and is described as the systemic broad-range long-lasting resistance to a pathogen that occurs after exposure of part of a plant to a microbe.

Current studies are focusing on: a)Understanding the biochemical mechanisms by which NPR1 regulates gene expression; b)Deciphering the NPR1 signal transduction pathway in Arabidopsisusing biochemical and proteomic tools; c)Engineering disease resistance in grapevine (Vitis vinifera).

Tomáš Hudlický, PhD

Email: thudlicky@brocku.ca
Tel: +1-905-688-5550 ext. 4956

Our research program is devoted to several projects in asymmetric synthesis and the total synthesis of natural products.  Two groups of alkaloids are targeted in the total synthesis effort: morphine, because of its analgesic properties, and pancratistatin, a powerful anti-cancer agent.

The key philosophy applied to all problems in our research group is the issue of efficiency and brevity becausethese parameters provide for less waste generation in manufacturing.

Paul Zelisko, PhD

Director

Email: pzelisko@brocku.ca
Tel: +1-905-688-5550 ext. 4389

Of particular interest to our group is the study of “green” methodologies in silicon chemistry, which includes exploring silicon biotechnology, and reactions that can performed in the absence of solvent, or performed in/on water.   A key part of our work in silicon biotechnology involves studying the use of enzymes as a green method for synthesizing polymeric silicon species: linear polymers, elastomers, and silicates.

We are using both traditional methodologies in silicon chemistry and biotechnology to synthesize linear, cross-linked, and macrocyclic (60+ atom) silicone systems for a number of different applications such as phospholipid mimics, surfactants, metal chelators, and liners for prosthetic devices to name but a few.