For complete Publication and Patent lists please visit the individual websites for the Member Researchers.


  1. Yang, Q; Easson, M; Simonescu, R; Hajicek, J; Thamm, A; Salim, V; De Luca, V. Biochemical assembly of corynanthean, strychnos, iboga and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine.  Proc. Natl. Acad. Sci. USA, 2018, in press.
  2. Qu, Y; Thamm, AMK; Czerwinski, M; Masada, S; Kim, KH; Jones, G; Liang, P; De Luca, V. Geissoschizine synthase controls flux in the formation of monoterpenoid indole alkaloids in a Catharanthus roseus mutant.  Planta, 2018, DOI: 10.1007/s00425-017-2812-7.
  3. Edge, A; Qu, Y; Easson, MLAE; Thamm, AMK; Kim, KH; De Luca, V. A tabersonine 3-reductase Catharanthus roseus mutant accumulates vindoline pathway intermediates. Planta, 2018, DOI: 10.1007/s00425-017-2775-8.
  4. Naimi, M; Vlavcheski, F; Murphy, B; Hudlicky, T; Tsiani, E. Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation. Clinical and Experimental Pharmacology and Physiology, 201744(1), 94-102.
  5. Ghavre, M; Froese, J; Murphy, B; Simionescu, R; Hudlicky, T. A formal approach to xylosmin and flacourtosides E and F: Chemoenzymatic total synthesis of the hydroxylated cyclohexenone carboxylic acid moiety of xylosmin. Organic Letters, 201719(5): 1156-1159.
  6. Frampton, MB; Marquardt, D; Letofsky-Papst, I; Pabst, G; Zelisko, PM. Analysis of Trisiloxane Phosphocholine Bilayers.  Langmuir, 2017, 33, 4948-4953.
  7. Nasresfahani, A; Zelisko, PM.  Synthesis of a Self-Healing Siloxane-Based Elastomer Cross-Linked via a Furan-Modified Polyhedral Oligomeric Silsesquioxane: Investigation of a Thermally Reversible Silicon-Based Cross-Link.  Polymer Chemistry, 2017, 8, 2942-2952.
  8. Demessie, Z; Woolfson, KN; Yu, F; Qu, Y; De Luca, V. The ATP binding cassette transporter, VmTPT2/VmABCG1, is involved in export of the monoterpenoid indole alkaloid, vincamine in Vinca minor leaves.  Phytochemistry, 2017, 140, 118-124.
  9. Frampton, MB; Zelisko, PM. Biocatalysis in Silicon Chemistry. Chemistry – An Asian Journal, 2017, 12, 1153-1167.
  10. Behie, SW; Moreira, CC; Sementchoukova, I; Barelli, L; Zelisko, PM; Bidochka, MJ. Trading Insect Nitrogen for Photosynthate: Carbon Translocation from a Plant to an Insect Pathogenic, Endophytic Fungus.  Nature Communications2017, 8, 14245 DOI: 10.1038/ncomms14245.
  11. Ma, D; Pignanelli, C; Tarade, D; Gilbert, T; Noel, M; Mansour, F; Adams, S; Dowhayko, A; Stokes, K; Vshyvenko, S; Hudlicky, T; McNulty, J; Pandey, S. Cancer cell mitochondria targeting bypancratistatin analogs is dependent on functional complex II and III. Scientific Reports, 20177, 42957.
  12. Wiens, B; De Luca, V. Molecular & biochemical characterization of a benzenoid/phenyl-propanoid meta/paraO-methyltransferase from R. serpentina roots. Phytochemistry, 2016132, 5-15. 
  13. Hudlicky, T; Endoma-Arias, MA. Chemoenzymatic total synthesis of (+)-galanthamine and (+)-narwedine from phenethylacetate. Chemistry – A European Journal, 201622(41), 14540-14543.
  14. Frampton, MB; Zelisko, PM.  A Short Synthesis of Siloxane Phosphocholines.  European Journal of Lipid Science and Technology, 2016, 119.  DOI:  10.1002/ejlt.201600248.
  15. Rycek, L; Hayward, JJ; Latif, MA; Tanko, J; Simionescu, R; Hudlicky, T. Chemoenzymatic total synthesis of hydromorphone by an oxidative dearomatization/intramolecular [4+2] cycloaddition sequence: A second-generation approach. Journal of Organic Chemistry, 201681(22), 10930-10941.
  16. Qu, Y; Simonescu, R; De Luca, V. Monoterpene indole alkaloids from the fruit of Tabernaemontana litoralis and differential alkaloid composition in various fruit components. Journal of Natural Products, 201679, 3143-3947. 
  17. Cázares, P; Levac, D; De Luca, V. Rauvolfia serpentina N-methyltransferases involved in ajmaline and Nβ-methylajmaline biosynthesis belong to a gene family derived from γ-tocopherol methyltransferase. Plant Journal, 201687, 335-342. 
  18. Froese, J; Overbeeke, C; Hudlicky, T. (2016). Chemoenzymatic synthesis of pleiogenone A: An antiproliferative trihydroxyalkylcyclohexenone isolated from Pleiogynium timorense. Chemistry – A European Journal, 201622(18), 6190-6184.
  19. Kuai, X; Després, C. Defining Arabidopsis NPR1 orthologs in crops for translational plant immunity. Canadian Journal of Plant Pathology, 201638, 25-30.
  20. Naoum, R; Séguin, JP; Trant, JF; Frampton, MB; Hudlicky, T; Zelisko PM. A chemoenzymatic route to chiral siloxanes. Tetrahedron, 201672(27-28): 4027-4031.
  21. Kuai, X; MacLeod, BJ: Després, C. Integrating data on the Arabidopsis NPR1/NPR3/NPR4 salicylic acid receptors; a differentiating argument. Frontiers in Plant Science20156, 235.
  22. Frampton, MB; Marquardt, D; Jones, TRB; Harroun, TA; Zelisko, PM.  Macrocyclic Oligoesters Incorporating a Cyclotetrasiloxane Ring.  Biomacromolecules, 2015, 16, 2091-2100.
  23. Khan, M; Ragni, L; Tabb, P; Salasini, B; Chatfield, S; Datla, R; Lock, J;Kuai, X; Després, C; Proveniers, M; Yongguo, C; Xiang, D; Morin, H; Rullière, J-P; Citerne, S; Hepworth, S; Pautot, V. Repression of lateral organ boundary genes by PENNYWISE and POUND-FOOLISH is essential for meristem maintenance and flowering in Arabidopsis thaliana. Plant Physiology, 2015169, 2166-2186.
  24. Frampton, MB; Jones, TRB; Zelisko, PM. Cyclotetrasiloxane Frameworks for the Chemoenzymatic Synthesis of Oligoesters.  RSC Advances, 2015, 5, 1999-2008.
  25. Frampton, MB; Zelisko, PM.  Chain Length Selectivity During the Polycondensation of Siloxane-Containing Esters and Alcohols by Immobilized Candida antarcticaLipase B.  Enzyme Microb. Technol., 2014, 58-59, 87-92.
  26. Frampton, MB; Séguin, JP; Marquardt, D; Harroun, TA; Zelisko, PM.  Synthesis of Polyesters Containing Disiloxane Subunits: Structural Characterization, Kinetics, and an Examination of the Thermal Tolerance of Novozym-435.  J. Mol. Cat. B.: Enzymatic.   2013, 85-86, 149-155.
  27. Wu, Y; Zhang, D; Chu, JY; Boyle, P; Wang, Y; Brindle, ID; De Luca, V; Després, C. The Arabidopsis NPR1 Protein Is a Receptor for the Plant Defense Hormone Salicylic Acid. Cell Reports, 20121, 639-647.
  28. Shearer, HL; Cheng, YT; Wang, L; Liu, J; Boyle, P; Després, C; Zhang, Y; Li, X; Fobert, PR. Arabidopsis Clade I TGA Transcription Factors Regulate Plant Defenses in an NPR1-Independent Fashion. Mol. Plant Microbe Interact.,201225,1459-1468.
  29. Behie, SW; Zelisko, PM; Bidochka, MJ. Endophytic Insect-Parasitic Fungi Translocate Nitrogen Directly from Insects to Plants, Science, 2012, 336, 1576-1577.


  1. Qu, Y. and De Luca, V. Compositions and methods for making terpenoid indole alkaloids.  March 2, 2017. PCT CA2017050284
  2. Hudlicky, T. and Froese, J.  Processes for the preparation of hydroxylated cyclohexyl compounds. United States. US 62/303,444. 2016/03/04.
  3. Frampton, MB, Zelisko, PM, Marquardt, D. 2016. Siloxane-Containing Phospholipids, Compositions and Uses Thereof. US Patent Application 15/618,435 (Publication Number US-2017-0355721-A1), Filed June 10, 2016. Patent Pending.
  4. Zelisko, PM; Frampton, MB.  Siloxane-Containing Hybrid Materials, US Patent 9,481,766 to Brock University.   Issued November 1, 2016.
  5. Zelisko, PM; Séguin, JP.  Silane Containing Anti-Corrosion Coatings for Steel Articles, U.S. Patent 9,403,993 to Vanchem Performance Chemicals.  Issued August 2, 2016.
  6. Qu, Y. and De Luca, V. Compositions and methods for making terpenoid indole alkaloids. March 4, 2016 : Provisional patent # 62/302,342.
  7. Hudlicky, T., Carroll, RJ., Leisch, H., Machara, A., Werner, L., and Endomsa-Arias, MA.  Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids. United States. US 9340550. 2011/07/08.
  8. Varghese, V. and Hudlicky, T.  Process for preparing morphine compounds. Canada. CA 2882694. 2015/02/23.
  9. Hudlicky, T., Endoma-Arias, MA., Snajdr, I., Machara, A., and Murphy, BA.  Methods for the preparation of hydromorphine. Canada. CA 2881229. 2015/02/06.
  10. Zelisko, PM; Frampton, MB.  Lipase-Mediated Synthesis of Hyperbranched Cyclotetrasiloxane Oligoesters and Their Use as Coatings, Canadian Patent Application No. 2,884,906 to Brock University.   Filed March 12, 2015.  Patent Pending.
  11. Hudlicky, T., Endoma-Arias, MA., Murphy, BA., Snajdr, I., and Machara, A.  Methods for the preparation of hydromorphone from thebaine via oripavine. Canada. CA 2881229.  2015/02/06.
  12. Després, C. Method of activating immune response in plants (granted).US 20140031234 A1.
  13. Hudlicky, T., Brindle, ID., and Endoma-Arias, MA.  Methods and apparatus for time-pulsed chromatography. United States. US 20140326670. 2014/05/05.
  14. Després, C. A method of activating immune response in plants (pending). CA 2818287 A1.
  15. Hudlicky, T. and Endoma-Arias, MA.Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans. Canada. CA 2863242. 2013/01/30.
  16. Després, C and Fobert, PR. Redox Switch Regulation of Plant Transcription Factors. Provisional patent.
  17. Zelisko, PM; Arnelien, K; Frampton, M. Enzyme-Mediated Cross-Linking of Silicone Polymers, US Patent 8,383,755 to Brock University.  Issued February 26, 2013
  18. Hudlicky, T. and Collins, J.  C-1 analogs of pancratistatin and 7-deoxypancratistatin and processes for their preparation. United States.  US 8703792. 2011/09/01.