Dr. Jeffrey A. Stuart

Dr. Jeffrey A. Stuart

CCOVI Fellow
Associate Professor of Biological Sciences
Faculty of Mathematics and Science, Brock University, St. Catharines, Ont.
Email: jstuart@brocku.ca
Phone: 905-688-5550 x4814
Fax: 905-688-1855
Office: MC F224

BSc in Biology, University of Guelph, Guelph, Ont.
PhD in Zoology, University of Guelph, Guelph, Ont.

Human Physiology
Cell Physiology

Biological activities of resveratrol and other red-wine polyphenols.
Molecular mechanisms underlying longevity.

Selected Publications and Presentations

  • Kronenberg, G., Gertz, K., Overall, R.W., Harms, C., Klein, J., Page, M.M., Stuart, J.A., Endres, M., 2011.  Folate deficiency increases mtDNA and D-1 mtDNA deletion in aged brain of mice lacking uracil-DNA glycosylase.  Exptl. Neurol.  In press.
  • Salway, K.D., Gallagher, E.J. and Stuart, J.A., 2011.  Longer-lived mammals and birds have higher levels of heat shock proteins.  Mech. Age. Devel.  In press.
  • Robb, E.L. and Stuart, J.A., 2011.  Resveratrol interacts with estrogen receptor-β to inhibit cell replicative growth and enhance stress resistance by upregulating mitochondrial superoxide dismutase.  Free Radic. Biol. Med.  In press.
  • Stuart, J.A. and Page, M.M., 2010.  Plasma [IGF-1] is negatively correlated with body mass in a comparison of 36 mammalian species.  Mech. Age. Devel.131, 591-598.
  • Salway, K.D. and Stuart, J.A., 2010.  Antioxidant enzymes and oxidative damage biomarkers in heart and selected other tissues of estivating and arousing land snails (Achatina fulica). Comp. Biochem. Physiol. 157, 229-36.
  • Salway, K.D., Page, M. M., Faure, P.A., Burness, G. and Stuart, J.A., 2010.Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species.  AGE.  Published online Jun 22.
  • Robb. E.L. and Stuart, J.A., 2010. trans-Resveratrol as a neuroprotectant. Molecules 15, 1196-1212.
  • Page, M.M., Robb, E.L., Salway, K.D., and Stuart, J.A., 2010. Mitochondrial redox metabolism: aging, longevity and dietary effects.  Mech. Ageing and Devel.  131, 242-252.
  • Page, M.M., Richardson, J., Wiens, B.E., Tiedtke, E., Peters, C.W., Faure, P.A., Burness, G. and Stuart, J.A., 2010.  Antioxidant enzyme activities are not broadly correlated with longevity in 14 endotherm species. AGE.  32, 255-270.
  • Page, M.M., Salway, K.D., Ip, Y.K., Chew, S.F., Warren, S.A., Ballantyne, J.S. and Stuart, J.A., 2010.  Upregulation of intracellular antioxidant enzymes in brain and heart during estivation in the African lungfish Protopterus dolloi.  J. Comp. Physiol. B 180, 361-369.
  • Stuart presented "Discovering the biological activities of resveratrol - an emerging nutraceutical" at the research café "Curing what ails us - from discovery to market" during the 3-part series "Mapping the New Knowledge" organized by the Grad Students' Association at Brock University, St. Catharines, March 2010.
  • Page, M.M, Salmon, A.B., Leiser, S.F., Robb, E.L., Brown, M.F., Miller, R.A. and Stuart, J.A. 2009.  Mechanisms of stress resistance in Snell dwarf mouse fibroblasts:  enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism.  Free Radic. Biol. Med46,1109-1118.
  • Robb, E.L., Page, M.M. and Stuart, J.A., 2009.  Mitochondria, cellular stress resistance, somatic cell depletion and lifespan.  Current Aging Science 1, 12-27.
  • Robb, E.L., P. Zelisko, and J.A. Stuart presented "MnSOD plays an important role in resveratrol's biological effects" at the Society for Free Radical Biology and Medecine Annual Conference in San Francisco in Nov. 2009.
  • Robb, E.L., P. Zelisko, and J.A. Stuart presented " Polyphenols: resveratrol targets the mitochondrial antioxidant enzyme manganese superoxide dismutase and increase cellular stress resistance. Polyphenols in human health" in Harrogate, UK in Dec. 2009.
  • Stuart, J.A. 2009. Editor of Mitochondrial DNA: Methods and Protocols, 2nd edition. Volume 197 In: Methods in Molecular Biology, Human Press, Totowa, New Jersey.
  • Page, M.M, A.B. Salmon, S.F. Leiser, E.L. Robb, M.F. Brown, R.A. Miller, and J.A. Stuart. 2009. Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism. Free Radic. Biol. Med, 46, 1109-1118.
  • Robb, E.L., M.M. Page, and J.A. Stuart. 2009. Mitochondria, cellular stress resistance, somatic cell depletion and lifespan. Curr. Aging Sci., 1, 12-27.
  • Page, M.M., Peters, C.W., Staples, J.F. and Stuart, J.A., 2009. Intracellular superoxide dismutases are not altered during hibernation in the 13-lined ground squirrel Spermophilus tridecemlineatus. Comp. Biochem. Physiol. A Mol. Integr. Physiol.152,115-22.
  • Page, M.M. and Stuart, J.A. In vitro measurement of mitochondrial DNA base excision repair enzyme activities. In: Mitochondrial DNA: Methods and Protocols, 2nd edition, Ed. J.A. Stuart.  Methods in Molecular Biology Series, J.M. Walker, Human Press, Totowa, New Jersey. June 2009.
  • Robb, E.L., Winkelmolen, L., Visanji, N., Brotchie, J., Stuart, J.A., 2008. Dietary resveratrol administration increases MnSOD expression and activity in mouse brain. Biochem. Biophys. Res. Commun. 372, 254-9.
  • Robb, E.L., Page, M.M., Wiens, B.E. and Stuart, J.A., 2008. A specific, progressive and profound induction of mitochondrial superoxide dismutase in human cells exposed to trans-resveratrol. Biochem. Biophys. Res. Commun. 367, 406-412.
  • Stuart, J.A. and Page, M.M. DNA oxidative damage and cancer. Oxidative Stress in Aging: From Model Systems to Human Diseases. Humana Press, May 2008.


Dr. Jeffrey Stuart